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The Impact of Vitamin E Isoforms on Asthma and Allergy

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Vitamin E in Human Health

Part of the book series: Nutrition and Health ((NH))

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Abstract

Asthma and allergic disease result from complex environmental and genetic interactions. These factors have been identified by epidemiological studies, randomized prevention trials, and animal models. Vitamin E is one of the environmental factors that can regulate responses to challenge with allergens. Reports for vitamin E have seemingly varied outcomes regarding benefits of vitamin E, but these differences are consistent with the differential functions of the isoforms of vitamin E. Mechanistic studies have identified opposing functions of the vitamin E isoforms α-tocopherol and γ-tocopherol. Moreover, differences in global prevalence of asthma may be an outcome, at least in part, of differences in amount of isoforms of tocopherols. In order to interpret human and preclinical studies, reports need to include measurements of the tocopherol isoforms in the treatments, in vehicles for the treatments, and in the plasma and/or tissues before and after intervention. Studies of differential regulation of inflammation by tocopherol isoforms provide a foundation for development of interventions to improve lung function in disease and raise the possibility of early life dietary interventions to limit the development of lung disease.

Sources of Support: This study was supported by National Institutes of Health Grants R01AI127695, U01AI131337, and R01 AT004837.

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References

  1. Martinez FD. Genes, environments, development and asthma: a reappraisal. Eur Respir J. 2007;29(1):179–84.

    Article  CAS  PubMed  Google Scholar 

  2. Palli D, Masala G, Vineis P, Garte S, Saieva C, Krogh V, et al. Biomarkers of dietary intake of micronutrients modulate DNA adduct levels in healthy adults. Carcinogenesis. 2003;24(4):739–46.

    Article  CAS  PubMed  Google Scholar 

  3. Fiscus LC, Van Herpen J, Steeber DA, Tedder TF, Tang ML. L-Selectin is required for the development of airway hyperresponsiveness but not airway inflammation in a murine model of asthma. J Allergy Clin Immunol. 2001;107(6):1019–24.

    Article  CAS  PubMed  Google Scholar 

  4. Hakugawa J, Bae SJ, Tanaka Y, Katayama I. The inhibitory effect of anti-adhesion molecule antibodies on eosinophil infiltration in cutaneous late phase response in Balb/c mice sensitized with ovalbumin (OVA). J Dermatol. 1997;24:73–9.

    Article  CAS  PubMed  Google Scholar 

  5. Sagara H, Matsuda H, Wada N, Yagita H, Fukuda T, Okumura K, et al. A monoclonal antibody against very late activation antigen-4 inhibits eosinophil accumulation and late asthmatic response in a guinea pig model of asthma. Int Arch Allergy Immunol. 1997;112:287–94.

    Article  CAS  PubMed  Google Scholar 

  6. Chin JE, Hatfield CA, Winterrowd GE, Brashler JR, Vonderfecht SL, Fidler SF, et al. Airway recruitment of leukocytes in mice is dependent on alpha4-integrins and vascular cell adhesion molecule-1. Am J Physiol. 1997;272:L219–L29.

    Article  CAS  PubMed  Google Scholar 

  7. Cook-Mills JM, Deem TL. Active participation of endothelial cells in inflammation. J Leukoc Biol. 2005;77(4):487–95.

    Article  CAS  PubMed  Google Scholar 

  8. Vestweber D. Novel insights into leukocyte extravasation. Curr Opin Hematol. 2012;19(3):212–7.

    Article  CAS  PubMed  Google Scholar 

  9. Muller WA. Mechanisms of leukocyte transendothelial migration. Annu Rev Pathol. 2011;6:323–44.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Yang L, Cohn L, Zhang DH, Homer R, Ray A, Ray P. Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation. J Exp Med. 1998;188:1739–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Mould AW, Ramsay AJ, Matthaei KI, Young IG, Rothenberg ME, Foster PS. The effect of IL-5 and eotaxin expression in the lung on eosinophil trafficking and degranulation and the induction of bronchial hyperreactivity. J Immunol. 2000;164:2142–50.

    Article  CAS  PubMed  Google Scholar 

  12. Bousquet J, Bousquet PJ, Godard P, Daures JP. The public health implications of asthma. Bull World Health Organ. 2005;83(7):548–54.

    PubMed  PubMed Central  Google Scholar 

  13. Vollmer WM, Osborne ML, Buist AS. 20-year trends in the prevalence of asthma and chronic airflow obstruction in an HMO. Am J Respir Crit Care Med. 1998;157(4 Pt 1):1079–84.

    Article  CAS  PubMed  Google Scholar 

  14. Friebele E. The attack of asthma. Environ Health Perspect. 1996;104(1):22–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. van Schayck CP, Smit HA. The prevalence of asthma in children: a reversing trend. Eur Respir J. 2005;26(4):647–50.

    Article  PubMed  Google Scholar 

  16. CDC National Asthma Control Program. http://www.cdc.gov/asthma/impacts_nation/asthmafactsheet.pdf (2012).

  17. Akinbami LJ, Moorman JE, Bailey C, Zahran HS, King M, Johnson CA, et al. Trends in asthma prevalence, health care use, and mortality in the United States, 2001–2010. NCHS Data Brief. 2012;(94):1–8.

    Google Scholar 

  18. Center For Disease Control Report. http://www.cdc.gov/nchs/data/databriefs/db121.pdf (2013).

  19. Uauy R, Hoffman DR, Birch EE, Birch DG, Jameson DM, Tyson J. Safety and efficacy of omega-3 fatty acids in the nutrition of very low birth weight infants: soy oil and marine oil supplementation of formula. J Pediatr. 1994;124(4):612–20.

    Article  CAS  PubMed  Google Scholar 

  20. Cook-Mills JM, McCary CA. Isoforms of vitamin E differentially regulate inflammation. Endocr Metab Immune Disord Drug Targets. 2010;10:348–66.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Bousquet J, Anto J, Auffray C, Akdis M, Cambon-Thomsen A, Keil T, et al. MeDALL (Mechanisms of the development of ALLergy): an integrated approach from phenotypes to systems medicine. Allergy. 2011;66(5):596–604.

    Article  CAS  PubMed  Google Scholar 

  22. Fedulov AV, Leme A, Yang Z, Dahl M, Lim R, Mariani TJ, et al. Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility. Am J Respir Cell Mol Biol. 2008;38(1):57–67.

    Article  CAS  PubMed  Google Scholar 

  23. Odaka Y, Nakano M, Tanaka T, Kaburagi T, Yoshino H, Sato-Mito N, et al. The influence of a high-fat dietary environment in the fetal period on postnatal metabolic and immune function. Obesity (Silver Spring). 2010;18(9):1688–94.

    Article  CAS  Google Scholar 

  24. Lim RH, Kobzik L, Dahl M. Risk for asthma in offspring of asthmatic mothers versus fathers: a meta-analysis. PLoS One. 2010;5(4):e10134.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  25. Izzotti A, Balansky RM, Cartiglia C, Camoirano A, Longobardi M, De Flora S. Genomic and transcriptional alterations in mouse fetus liver after transplacental exposure to cigarette smoke. FASEB J. 2003;17(9):1127–9.

    Article  CAS  PubMed  Google Scholar 

  26. Vanhees K, Coort S, Ruijters EJ, Godschalk RW, van Schooten FJ. Barjesteh van Waalwijk van Doorn-Khosrovani S. Epigenetics: prenatal exposure to genistein leaves a permanent signature on the hematopoietic lineage. FASEB J. 2011;25(2):797–807.

    Article  CAS  PubMed  Google Scholar 

  27. Rebholz SL, Jones T, Burke KT, Jaeschke A, Tso P, D’Alessio DA, et al. Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. Am J Physiol Endocrinol Metab. 2012;302:E449–57.

    Article  CAS  PubMed  Google Scholar 

  28. Burke KT, Colvin PL, Myatt L, Graf GA, Schroeder F, Woollett LA. Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the golden Syrian hamster. J Lipid Res. 2009;50(6):1146–55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Woollett LA. Maternal cholesterol in fetal development: transport of cholesterol from the maternal to the fetal circulation. Am J Clin Nutr. 2005;82(6):1155–61.

    Article  CAS  PubMed  Google Scholar 

  30. Lim RH, Kobzik L. Maternal transmission of asthma risk. Am J Reprod Immunol. 2009;61(1):1–10.

    Article  PubMed  Google Scholar 

  31. Liu X, Agerbo E, Schlunssen V, Wright RJ, Li J, Munk-Olsen T. Maternal asthma severity and control during pregnancy and risk of offspring asthma. J Allergy Clin Immunol. 2017;27(17):30854–0.

    Google Scholar 

  32. Abdala-Valencia H, Berdnikovs S, Soveg F, Cook-Mills JM. Alpha-Tocopherol supplementation of allergic female mice inhibits development of CD11c+CD11b+ dendritic cells in utero and allergic inflammation in neonates. Am J Physiol Lung Cell Mol Physiol. 2014;307(00132):L482–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Abdala-Valencia H, Soveg F, Cook-Mills JM. γ-Tocopherol supplementation of allergic female mice augments development of CD11c+CD11b+ dendritic cells in utero and allergic inflammation in neonates. Am J Physiol Lung Cell Mol Physiol. 2016;310(8):L759–L71.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Hamada K, Suzaki Y, Goldman A, Ning YY, Goldsmith C, Palecanda A, et al. Allergen-independent maternal transmission of asthma susceptibility. J Immunol. 2003;170(4):1683–9.

    Article  CAS  PubMed  Google Scholar 

  35. Fedulov AV, Leme AS, Kobzik L. Duration of allergic susceptibility in maternal transmission of asthma risk. Am J Reprod Immunol. 2007;58(2):120–8.

    Article  CAS  PubMed  Google Scholar 

  36. Hubeau C, Apostolou I, Kobzik L. Targeting of CD25 and glucocorticoid-induced TNF receptor family-related gene-expressing T cells differentially modulates asthma risk in offspring of asthmatic and normal mother mice. J Immunol. 2007;178(3):1477–87.

    Article  CAS  PubMed  Google Scholar 

  37. Hubeau C, Apostolou I, Kobzik L. Adoptively transferred allergen-specific T cells cause maternal transmission of asthma risk. Am J Pathol. 2006;168(6):1931–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Herz U, Joachim R, Ahrens B, Scheffold A, Radbruch A, Renz H. Allergic sensitization and allergen exposure during pregnancy favor the development of atopy in the neonate. Int Arch Allergy Immunol. 2001;124(1-3):193–6.

    Article  CAS  PubMed  Google Scholar 

  39. Herz U, Joachim R, Ahrens B, Scheffold A, Radbruch A, Renz H. Prenatal sensitization in a mouse model. Am J Respir Crit Care Med. 2000;162(3 Pt 2):S62–5.

    Article  CAS  PubMed  Google Scholar 

  40. Jarrett E, Hall E. Selective suppression of IgE antibody responsiveness by maternal influence. Nature. 1979;280(5718):145–7.

    Article  CAS  PubMed  Google Scholar 

  41. Hunter SC, Cahoon EB. Enhancing vitamin E in oilseeds: unraveling tocopherol and tocotrienol biosynthesis. Lipids. 2007;42(2):97–108.

    Article  CAS  PubMed  Google Scholar 

  42. Wolf G. How an increased intake of alpha-tocopherol can suppress the bioavailability of gamma-tocopherol. Nutr Rev. 2006;64(6):295–9.

    Article  PubMed  Google Scholar 

  43. Leonard SW, Paterson E, Atkinson JK, Ramakrishnan R, Cross CE, Traber MG. Studies in humans using deuterium-labeled alpha- and gamma-tocopherols demonstrate faster plasma gamma-tocopherol disappearance and greater gamma-metabolite production. Free Radic Biol Med. 2005;38(7):857–66.

    Article  CAS  PubMed  Google Scholar 

  44. Bella DL, Schock BC, Lim Y, Leonard SW, Berry C, Cross CE, et al. Regulation of the alpha-tocopherol transfer protein in mice: lack of response to dietary vitamin E or oxidative stress. Lipids. 2006;41(2):105–12.

    Article  CAS  PubMed  Google Scholar 

  45. Cook-Mills JM, Abdala-Valencia H, Hartert T. Two faces of vitamin e in the lung. Am J Respir Crit Care Med. 2013;188(3):279–84.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Muller-Schmehl K, Beninde J, Finckh B, Florian S, Dudenhausen JW, Brigelius-Flohe R, et al. Localization of alpha-tocopherol transfer protein in trophoblast, fetal capillaries’ endothelium and amnion epithelium of human term placenta. Free Radic Res. 2004;38(4):413–20.

    Article  PubMed  CAS  Google Scholar 

  47. Jishage K, Tachibe T, Ito T, Shibata N, Suzuki S, Mori T, et al. Vitamin E is essential for mouse placentation but not for embryonic development itself. Biol Reprod. 2005;73(5):983–7.

    Article  CAS  PubMed  Google Scholar 

  48. Yoshida Y, Saito Y, Jones LS, Shigeri Y. Chemical reactivities and physical effects in comparison between tocopherols and tocotrienols: physiological significance and prospects as antioxidants. J Biosci Bioeng. 2007;104(6):439–45.

    Article  CAS  PubMed  Google Scholar 

  49. Keiko Nishio MH, Akazawa Y, Shichiri M, Iwahashi H, Yoshihisa Hagihara YY, Niki E. Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols. Redox Biol. 2013;1:97–103.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  50. McCary CA, Yoon Y, Panagabko C, Cho W, Atkinson J, Cook-Mills JM. Vitamin E isoforms directly bind PKCalpha and differentially regulate activation of PKCalpha. Biochem J. 2012;441:189–98.

    Article  CAS  PubMed  Google Scholar 

  51. Berdnikovs S, Abdala-Valencia H, McCary C, Somand M, Cole R, Garcia A, et al. Isoforms of Vitamin E have Opposing Immunoregulatory Functions during Inflammation by Regulating Leukocyte Recruitment. J Immunol. 2009;182:4395–405.

    Article  CAS  PubMed  Google Scholar 

  52. Abdala-Valencia H, Berdnikovs S, Cook-Mills JM. Vitamin E isoforms differentially regulate intercellular adhesion molecule-1 activation of PKCalpha in human microvascular endothelial cells. PLoS One. 2012;7(7):e41054.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Jourd’heuil D, Morise Z, Conner EM, Kurose I, Grisham MB. Oxidant-regulation of gene expression in the chronically inflamed intestine. Keio J Med. 1997;46(1):10–5.

    Article  PubMed  Google Scholar 

  54. de Luis DA, Armentia A, Aller R, Asensio A, Sedano E, Izaola O, et al. Dietary intake in patients with asthma: a case control study. Nutrition. 2005;21(3):320–4.

    Article  PubMed  Google Scholar 

  55. Patel A, Liebner F, Netscher T, Mereiter K, Rosenau T. Vitamin E chemistry. Nitration of non-alpha-tocopherols: products and mechanistic considerations. J Org Chem. 2007;72(17):6504–12.

    Article  CAS  PubMed  Google Scholar 

  56. Fakhrzadeh L, Laskin JD, Laskin DL. Ozone-induced production of nitric oxide and TNF-alpha and tissue injury are dependent on NF-kappaB p50. Am J Physiol Lung Cell Mol Physiol. 2004;287(2):L279–85.. Epub 2004 Apr 2.

    Article  CAS  PubMed  Google Scholar 

  57. Wardlaw A. Eosinophil trafficking: new answers to old questions. Clin Exp Allergy. 2004;34(5):676–9.

    Article  CAS  PubMed  Google Scholar 

  58. Hernandez ML, Wagner JG, Aline Kala R, Mills K, Wells HB, Alexis NE, et al. Vitamin E gamma-tocopherol reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers. Free Radic Biol Med. 2013;8(13):00054–3.

    Google Scholar 

  59. Wiser J, Alexis NE, Jiang Q, Wu W, Robinette C, Roubey R, et al. In vivo gamma-tocopherol supplementation decreases systemic oxidative stress and cytokine responses of human monocytes in normal and asthmatic subjects. Free Radic Biol Med. 2008;45(1):40–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Wagner JG, Harkema JR, Jiang Q, Illek B, Ames BN, Peden DB. Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats. Toxicol Pathol. 2009;37(4):481–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Burbank AJ, Duran CG, Pan Y, Burns P, Jones S, Jiang Q, et al. Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma. J Allergy Clin Immunol. 2017;20(17):31110–7.

    Google Scholar 

  62. Duan L, Li J, Ma P, Yang X, Xu S. Vitamin E antagonizes ozone-induced asthma exacerbation in Balb/c mice through the Nrf2 pathway. Food Chem Toxicol. 2017;107(Pt A):47–56.

    Article  CAS  PubMed  Google Scholar 

  63. Wagner JG, Jiang Q, Harkema JR, Ames BN, Illek B, Roubey RA, et al. Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma. Clin Exp Allergy. 2008;38(3):501–11.

    Article  CAS  PubMed  Google Scholar 

  64. Peh HY, Ho WE, Cheng C, Chan TK, Seow AC, Lim AY, et al. Vitamin E isoform gamma-tocotrienol downregulates house dust mite-induced asthma. J Immunol. 2015;195(2):437–44.

    Article  CAS  PubMed  Google Scholar 

  65. Barthel SR, Johansson MW, McNamee DM, Mosher DF. Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma. J Leukoc Biol. 2008;83(1):1–12.

    Article  CAS  PubMed  Google Scholar 

  66. Marchese ME, Kumar R, Colangelo LA, Avila PC, Jacobs DR Jr, Gross M, et al. The vitamin E isoforms alpha-tocopherol and gamma-tocopherol have opposite associations with spirometric parameters: the CARDIA study. Respir Res. 2014;15(1):31.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Jordan JM, De Roos AJ, Renner JB, Luta G, Cohen A, Craft N, et al. A case-control study of serum tocopherol levels and the alpha- to gamma-tocopherol ratio in radiographic knee osteoarthritis: the Johnston County Osteoarthritis Project. Am J Epidemiol. 2004;159(10):968–77.

    Article  PubMed  Google Scholar 

  68. Dietrich M, Traber MG, Jacques PF, Cross CE, Hu Y, Block G. Does gamma-tocopherol play a role in the primary prevention of heart disease and cancer? A review. J Am Coll Nutr. 2006;25(4):292–9.

    Article  CAS  PubMed  Google Scholar 

  69. Munteanu A, Zingg JM. Cellular, molecular and clinical aspects of vitamin E on atherosclerosis prevention. Mol Asp Med. 2007;28(5-6):538–90.

    Article  CAS  Google Scholar 

  70. Siekmeier R, Steffen C, Marz W. Role of oxidants and antioxidants in atherosclerosis: results of in vitro and in vivo investigations. J Cardiovasc Pharmacol Ther. 2007;12(4):265–82.

    Article  CAS  PubMed  Google Scholar 

  71. Meydani M. Vitamin E modulation of cardiovascular disease. Ann N Y Acad Sci. 2004;1031:271–9.

    Article  CAS  PubMed  Google Scholar 

  72. Dutta A, Dutta SK. Vitamin E and its role in the prevention of atherosclerosis and carcinogenesis: a review. J Am Coll Nutr. 2003;22(4):258–68.

    Article  CAS  PubMed  Google Scholar 

  73. Cook-Mills JM, Marchese ME, Abdala-Valencia H. Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants. Antioxid Redox Signal. 2011;15(6):1607–38.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Cook-Mills JM. Eosinophil-endothelial cell interactions. Eosinophils in health and disease. In: Lee J, Rosenberg HF, editors. Eosinophils in health and disease. Atlanta: Elsevier; 2012. p. 139–53.

    Google Scholar 

  75. McCary CA, Abdala-Valencia H, Berdnikovs S, Cook-Mills JM. Supplemental and highly elevated tocopherol doses differentially regulate allergic inflammation: reversibility of alpha-tocopherol and gamma-tocopherol’s effects. J Immunol. 2011;186(6):3674–85.

    Article  CAS  PubMed  Google Scholar 

  76. Redlich CA, Grauer JN, Van Bennekum AM, Clever SL, Ponn RB, Blaner WS. Characterization of carotenoid, vitamin A, and alpha-tocopherol levels in human lung tissue and pulmonary macrophages. Am J Respir Crit Care Med. 1996;154:1436–43.

    Article  CAS  PubMed  Google Scholar 

  77. Cook-Mills JM, Avila PC. Vitamin E and D regulation of allergic asthma immunopathogenesis. Int Immunopharmacol. 2014;29(14):007.

    Google Scholar 

  78. Jiang Q, Christen S, Shigenaga MK, Ames BN. gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr. 2001;74(6):714–22.

    Article  CAS  PubMed  Google Scholar 

  79. Talegawkar SA, Johnson EJ, Carithers T, Taylor HA Jr, Bogle ML, Tucker KL. Total alpha-tocopherol intakes are associated with serum alpha-tocopherol concentrations in African American adults. J Nutr. 2007;137(10):2297–303.

    Article  CAS  PubMed  Google Scholar 

  80. Abdala-Valencia H, Berdnikovs S, Cook-Mills JM. Vitamin E isoforms as modulators of lung inflammation. Nutrients. 2013;5(11):4347–63.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  81. Bieri JG, Evarts RP. Tocopherols and fatty acids in American diets. The recommended allowance for vitamin E. J Am Diet Assoc. 1973;62(2):147–51.

    CAS  PubMed  Google Scholar 

  82. Bieri JG, Evarts RP. Vitamin E adequacy of vegetable oils. J Am Diet Assoc. 1975;66(2):134–9.

    CAS  PubMed  Google Scholar 

  83. Choo JH, Nagata M, Sutani A, Kikuchi I, Sakamoto Y. Theophylline attenuates the adhesion of eosinophils to endothelial cells. Int Arch Allergy Immunol. 2003;131(Suppl 1):40–5.

    Article  CAS  PubMed  Google Scholar 

  84. Miller M, Sung KL, Muller WA, Cho JY, Roman M, Castaneda D, et al. Eosinophil tissue recruitment to sites of allergic inflammation in the lung is platelet endothelial cell adhesion molecule independent. J Immunol. 2001;167(4):2292–7.

    Article  CAS  PubMed  Google Scholar 

  85. Davenpeck KL, Berens KL, Dixon RA, Dupre B, Bochner BS. Inhibition of adhesion of human neutrophils and eosinophils to P-selectin by the sialyl Lewis antagonist TBC1269: preferential activity against neutrophil adhesion in vitro. J Allergy Clin Immunol. 2000;105(4):769–75.

    Article  CAS  PubMed  Google Scholar 

  86. Meydani SN, Shapiro AC, Meydani M, Macauley JB, Blumberg JB. Effect of age and dietary fat (fish, corn and coconut oils) on tocopherol status of C57BL/6Nia mice. Lipids. 1987;22:345–50.

    Article  CAS  PubMed  Google Scholar 

  87. Myou S, Zhu X, Boetticher E, Myo S, Meliton A, Lambertino A, et al. Blockade of focal clustering and active conformation in beta 2-integrin-mediated adhesion of eosinophils to intercellular adhesion molecule-1 caused by transduction of HIV TAT-dominant negative Ras. J Immunol. 2002;169(5):2670–6.

    Article  CAS  PubMed  Google Scholar 

  88. Gobel Y, Koletzko B, Bohles HJ, Engelsberger I, Forget D, Le Brun A, et al. Parenteral fat emulsions based on olive and soybean oils: a randomized clinical trial in preterm infants. J Pediatr Gastroenterol Nutr. 2003;37(2):161–7.

    Article  PubMed  Google Scholar 

  89. Weiss ST. Diet as a risk factor for asthma. Ciba Found Symp. 1997;206:244–57.

    CAS  PubMed  Google Scholar 

  90. Troisi RJ, Willett WC, Weiss ST, Trichopoulos D, Rosner B, Speizer FE. A prospective study of diet and adult-onset asthma [see comments]. Am J Respir Crit Care Med. 1995;151:1401–8.

    Article  CAS  PubMed  Google Scholar 

  91. Dow L, Tracey M, Villar A, Coggon D, Margetts BM, Campbell MJ, et al. Does dietary intake of vitamins C and E influence lung function in older people? Am J Respir Crit Care Med. 1996;154:1401–4.

    Article  CAS  PubMed  Google Scholar 

  92. Smit HA, Grievink L, Tabak C. Dietary influences on chronic obstructive lung disease and asthma: a review of the epidemiological evidence. Proc Nutr Soc. 1999;58:309–19.

    Article  CAS  PubMed  Google Scholar 

  93. Tabak C, Smit HA, Rasanen L, Fidanza F, Menotti A, Nissinen A, et al. Dietary factors and pulmonary function: a cross sectional study in middle aged men from three European countries. Thorax. 1999;54(11):1021–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. Devereux G. Early life events in asthma--diet. Pediatr Pulmonol. 2007;42(8):663–73.

    Article  PubMed  Google Scholar 

  95. Martindale S, McNeill G, Devereux G, Campbell D, Russell G, Seaton A. Antioxidant intake in pregnancy in relation to wheeze and eczema in the first two years of life. Am J Respir Crit Care Med. 2005;171(2):121–8.

    Article  PubMed  Google Scholar 

  96. Hoskins A, Roberts JL 2nd, Milne G, Choi L, Dworski R. Natural-source d-alpha-tocopheryl acetate inhibits oxidant stress and modulates atopic asthma in humans in vivo. Allergy. 2012;67(5):676–82.

    Article  CAS  PubMed  Google Scholar 

  97. Devaraj S, Tang R, Adams-Huet B, Harris A, Seenivasan T, de Lemos JA, et al. Effect of high-dose alpha-tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease. Am J Clin Nutr. 2007;86(5):1392–8.

    Article  CAS  PubMed  Google Scholar 

  98. Allen S, Britton JR, Leonardi-Bee JA. Association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis. Thorax. 2009;64(7):610–9.

    Article  CAS  PubMed  Google Scholar 

  99. Kurti SP, Murphy JD, Ferguson CS, Brown KR, Smith JR, Harms CA. Improved lung function following dietary antioxidant supplementation in exercise-induced asthmatics. Respir Physiol Neurobiol. 2016;220:95–101.

    Article  CAS  PubMed  Google Scholar 

  100. Devereux G, Seaton A. Diet as a risk factor for atopy and asthma. J Allergy Clin Immunol. 2005;115(6):1109–17.

    Article  PubMed  Google Scholar 

  101. Pearson PJ, Lewis SA, Britton J, Fogarty A. Vitamin E supplements in asthma: a parallel group randomised placebo controlled trial. Thorax. 2004;59(8):652–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Hernandez M, Zhou H, Zhou B, Robinette C, Crissman K, Hatch G, et al. Combination treatment with high-dose vitamin C and alpha-tocopherol does not enhance respiratory-tract lining fluid vitamin C levels in asthmatics. Inhal Toxicol. 2009;21(3):173–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. Zahran HS, Bailey C. Factors associated with asthma prevalence among racial and ethnic groups-United States, 2009-2010 Behavioral Risk Factor Surveillance System. J Asthma. 2013;11:11.

    Google Scholar 

  104. Cook-Mills J, Gebretsadik T, Abdala-Valencia H, Green J, Larkin EK, Dupont WD, et al. Interaction of vitamin E isoforms on asthma and allergic airway disease. Thorax. 2016;71(10):954–6.

    Article  PubMed  Google Scholar 

  105. Jacobs RR, Boehlecke B, van Hage-Hamsten M, Rylander R. Bronchial reactivity, atopy, and airway response to cotton dust. Am Rev Respir Dis. 1993;148(1):19–24.

    Article  CAS  PubMed  Google Scholar 

  106. Delfino RJ, Quintana PJ, Floro J, Gastanaga VM, Samimi BS, Kleinman MT, et al. Association of FEV1 in asthmatic children with personal and microenvironmental exposure to airborne particulate matter. Environ Health Perspect. 2004;112(8):932–41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  107. Koskela H, Tukiainen H, Kononoff A, Pekkarinen H. Effect of whole-body exposure to cold and wind on lung function in asthmatic patients. Chest. 1994;105(6):1728–31.

    Article  CAS  PubMed  Google Scholar 

  108. Blanc PD, Eisner MD, Katz PP, Yen IH, Archea C, Earnest G, et al. Impact of the home indoor environment on adult asthma and rhinitis. J Occup Environ Med. 2005;47(4):362–72.

    Article  CAS  PubMed  Google Scholar 

  109. Hess KL, Babcock GF, Askew DS, Cook-Mills JM. A novel flow cytometric method for quantifying phagocytosis of apoptotic cells. Cytometry. 1997;27:145–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Elenius V, Palomares O, Waris M, Turunen R, Puhakka T, Ruckert B, et al. The relationship of serum vitamins A, D, E and LL-37 levels with allergic status, tonsillar virus detection and immune response. PLoS One. 2017;12(2):e0172350.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  111. Hamalainen N, Nwaru BI, Erlund I, Takkinen HM, Ahonen S, Toppari J, et al. Serum carotenoid and tocopherol concentrations and risk of asthma in childhood: a nested case-control study. Clin Exp Allergy. 2017;47(3):401–9.

    Article  CAS  PubMed  Google Scholar 

  112. Kalayci O, Besler T, Kilinc K, Sekerel BE, Saraclar Y. Serum levels of antioxidant vitamins (alpha tocopherol, beta carotene, and ascorbic acid) in children with bronchial asthma. Turk J Peds. 2000;42:17–21.

    CAS  Google Scholar 

  113. Kelly FJ, Mudway I, Blomberg A, Frew A, Sandstrom T. Altered lung antioxidant status in patients with mild asthma. Lancet. 1999;354:482–3.

    Article  CAS  PubMed  Google Scholar 

  114. Schunemann HJ, Grant BJ, Freudenheim JL, Muti P, Browne RW, Drake JA, et al. The relation of serum levels of antioxidant vitamins C and E, retinol and carotenoids with pulmonary function in the general population. Am J Respir Crit Care Med. 2001;163:1246–55.

    Article  CAS  PubMed  Google Scholar 

  115. Al-Abdulla NO, Al Naama LM, Hassan MK. Antioxidant status in acute asthmatic attack in children. J Pak Med Assoc. 2010;60(12):1023–7.

    PubMed  Google Scholar 

  116. Ratnasinghe D, Tangrea JA, Forman MR, Hartman T, Gunter EW, Qiao YL, et al. Serum tocopherols, selenium and lung cancer risk among tin miners in China. Cancer Causes Control. 2000;11(2):129–35.

    Article  CAS  PubMed  Google Scholar 

  117. Kleiber M. Metabolic turnover rate: a physiological meaning of the metabolic rate per unit body weight. J Theor Biol. 1975;53(1):199–204.

    Article  CAS  PubMed  Google Scholar 

  118. Terpstra AH. Differences between humans and mice in efficacy of the body fat lowering effect of conjugated linoleic acid: role of metabolic rate. J Nutr. 2001;131(7):2067–8.

    Article  CAS  PubMed  Google Scholar 

  119. Bachmanov AA, Reed DR, Beauchamp GK, Tordoff MG. Food intake, water intake, and drinking spout side preference of 28 mouse strains. Behav Genet. 2002;32(6):435–43.

    Article  PubMed  PubMed Central  Google Scholar 

  120. Villar J, Purwar M, Merialdi M, Zavaleta N, Ngoc TNN, Anthony J, et al. World Health Organisation multicentre randomised trial of supplementation with vitamins C and E among pregnant women at high risk for pre-eclampsia in populations of low nutritional status from developing countries. BJOG. 2009;116(6):780–8.

    Article  CAS  PubMed  Google Scholar 

  121. McCance DR, Holmes VA, Maresh MJ, Patterson CC, Walker JD, Pearson DW, et al. Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial. Lancet. 2010;376(9737):259–66.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  122. Hauth JC, Clifton RG, Roberts JM, Spong CY, Myatt L, Leveno KJ, et al. Vitamin C and E supplementation to prevent spontaneous preterm birth: a randomized controlled trial. Obstet Gynecol. 2010;116(3):653–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  123. Greenough A, Shaheen SO, Shennan A, Seed PT, Poston L. Respiratory outcomes in early childhood following antenatal vitamin C and E supplementation. Thorax. 2010;65(11):998–1003.

    Article  PubMed  Google Scholar 

  124. Kalpdev A, Saha SC, Dhawan V. Vitamin C and E supplementation does not reduce the risk of superimposed PE in pregnancy. Hypertens Pregnancy. 2011;30(4):447–56.

    Article  CAS  PubMed  Google Scholar 

  125. Gungorduk K, Asicioglu O, Gungorduk OC, Yildirim G, Besimoglu B, Ark C. Does vitamin C and vitamin E supplementation prolong the latency period before delivery following the preterm premature rupture of membranes? A randomized controlled study. Am J Perinatol. 2014;31(3):195–202.

    PubMed  Google Scholar 

  126. Betti M, Ambrogini P, Minelli A, Floridi A, Lattanzi D, Ciuffoli S, et al. Maternal dietary loads of alpha-tocopherol depress protein kinase C signaling and synaptic plasticity in rat postnatal developing hippocampus and promote permanent deficits in adult offspring. J Nutr Biochem. 2011;22(1):60–70.

    Article  CAS  PubMed  Google Scholar 

  127. Suchankova J, Voprsalova M, Kottova M, Semecky V, Visnovsky P. Effects of oral alpha-tocopherol on lung response in rat model of allergic asthma. Respirology. 2006;11(4):414–21.

    Article  PubMed  Google Scholar 

  128. Okamoto N, Murata T, Tamai H, Tanaka H, Nagai H. Effects of alpha tocopherol and probucol supplements on allergen-induced airway inflammation and hyperresponsiveness in a mouse model of allergic asthma. Int Arch Allergy Immunol. 2006;141(2):172–80.

    Article  CAS  PubMed  Google Scholar 

  129. Mabalirajan U, Aich J, Leishangthem GD, Sharma SK, Dinda AK, Ghosh B. Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model. J Appl Physiol. 2009;107(4):1285–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  130. Mamdouh Z, Mikhailov A, Muller WA. Transcellular migration of leukocytes is mediated by the endothelial lateral border recycling compartment. J Exp Med. 2009;206(12):2795–808.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  131. Mustacich DJ, Leonard SW, Devereaux MW, Sokol RJ, Traber MG. Alpha-tocopherol regulation of hepatic cytochrome P450s and ABC transporters in rats. Free Radic Biol Med. 2006;41(7):1069–78.

    Article  CAS  PubMed  Google Scholar 

  132. Abdala-Valencia H, Berdnikovs S, McCary CA, Urick D, Mahadevia R, Marchese ME, et al. Inhibition of allergic inflammation by supplementation with 5-hydroxytryptophan. Am J Physiol Lung Cell Mol Physiol. 2012;303:L642–L60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  133. Abdala-Valencia H, Earwood J, Bansal S, Jansen M, Babcock G, Garvy B, et al. Nonhematopoietic NADPH oxidase regulation of lung eosinophilia and airway hyperresponsiveness in experimentally induced asthma. Am J Physiol Lung Cell Mol Physiol. 2007;292(5):L1111–25.

    Article  CAS  PubMed  Google Scholar 

  134. Keshavan P, Deem TL, Schwemberger SJ, Babcock GF, Cook-Mills JM, Zucker SD. Unconjugated bilirubin inhibits VCAM-1-mediated transendothelial leukocyte migration. J Immunol. 2005;174:3709–18.

    Article  CAS  PubMed  Google Scholar 

  135. Wagner KH, Kamal-Eldin A, Elmadfa I. Gamma-tocopherol – an underestimated vitamin? Ann Nutr Metab. 2004;48(3):169–88.

    Article  CAS  PubMed  Google Scholar 

  136. Abdala-Valencia H, Cook-Mills JM. VCAM-1 signals activate endothelial cell protein kinase Ca via oxidation. J Immunol. 2006;177:6379–87.

    Article  CAS  PubMed  Google Scholar 

  137. Boyle FG, Yuhas RJ, Lien EL. Red blood cell and tissue phospholipid fatty acid profiles of weanling rats fed infant formula fat blends containing soy and/or corn oil. Ann Nutr Metab. 1996;40(4):234–42.

    Article  CAS  PubMed  Google Scholar 

  138. Nelson SE, Rogers RR, Frantz JA, Ziegler EE. Palm olein in infant formula: absorption of fat and minerals by normal infants. Am J Clin Nutr. 1996;64(3):291–6.

    Article  CAS  PubMed  Google Scholar 

  139. Blumer N, Herz U, Wegmann M, Renz H. Prenatal lipopolysaccharide-exposure prevents allergic sensitization and airway inflammation, but not airway responsiveness in a murine model of experimental asthma. Clin Exp Allergy. 2005;35(3):397–402.

    Article  CAS  PubMed  Google Scholar 

  140. Devereux G, Barker RN, Seaton A. Antenatal determinants of neonatal immune responses to allergens. Clin Exp Allergy. 2002;32(1):43–50.

    Article  CAS  PubMed  Google Scholar 

  141. Uthoff H, Spenner A, Reckelkamm W, Ahrens B, Wolk G, Hackler R, et al. Critical role of preconceptional immunization for protective and nonpathological specific immunity in murine neonates. J Immunol. 2003;171(7):3485–92.

    Article  CAS  PubMed  Google Scholar 

  142. Beckhaus AA, Garcia-Marcos L, Forno E, Pacheco-Gonzalez RM, Celedon JC, Castro-Rodriguez JA. Maternal nutrition during pregnancy and risk of asthma, wheeze, and atopic diseases during childhood: a systematic review and meta-analysis. Allergy. 2015;70(12):1588–604.

    Article  CAS  PubMed  Google Scholar 

  143. Miller DR, Turner SW, Spiteri-Cornish D, Scaife AR, Danielian PJ, Devereux GS, et al. Maternal vitamin D and E intakes during early pregnancy are associated with airway epithelial cell responses in neonates. Clin Exp Allergy. 2015;45(5):920–7.

    Article  CAS  PubMed  Google Scholar 

  144. Allan KM, Prabhu N, Craig LC, McNeill G, Kirby B, McLay J, et al. Maternal vitamin D and E intakes during pregnancy are associated with asthma in children. Eur Respir J. 2015;45(4):1027–36.

    Article  CAS  PubMed  Google Scholar 

  145. Kurukulaaratchy RJ, Waterhouse L, Matthews SM, Arshad SH. Are influences during pregnancy associated with wheezing phenotypes during the first decade of life? Acta Paediatr. 2005;94(5):553–8.

    Article  PubMed  Google Scholar 

  146. Celedon JC, Litonjua AA, Ryan L, Platts-Mills T, Weiss ST, Gold DR. Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life. Lancet. 2002;360(9335):781–2.

    Article  PubMed  Google Scholar 

  147. Kurukulaaratchy RJ, Matthews S, Waterhouse L, Arshad SH. Factors influencing symptom expression in children with bronchial hyperresponsiveness at 10 years of age. J Allergy Clin Immunol. 2003;112(2):311–6.

    Article  PubMed  Google Scholar 

  148. Latzin P, Frey U, Roiha HL, Baldwin DN, Regamey N, Strippoli MP, et al. Prospectively assessed incidence, severity, and determinants of respiratory symptoms in the first year of life. Pediatr Pulmonol. 2007;42(1):41–50.

    Article  CAS  PubMed  Google Scholar 

  149. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med. 1995;332(3):133–8.

    Article  CAS  PubMed  Google Scholar 

  150. Litonjua AA, Carey VJ, Burge HA, Weiss ST, Gold DR. Parental history and the risk for childhood asthma. Does mother confer more risk than father? Am J Respir Crit Care Med. 1998;158(1):176–81.

    Article  CAS  PubMed  Google Scholar 

  151. Folsgaard NV, Chawes BL, Rasmussen MA, Bischoff AL, Carson CG, Stokholm J, et al. Neonatal cytokine profile in the airway mucosal lining fluid is skewed by maternal atopy. Am J Respir Crit Care Med. 2012;185(3):275–80.

    Article  PubMed  CAS  Google Scholar 

  152. Sonnenschein-van der Voort AM, Jaddoe VW, Moll HA, Hofman A, van der Valk RJ, de Jongste JC, et al. Influence of maternal and cord blood C-reactive protein on childhood respiratory symptoms and eczema. Pediatr Allergy Immunol. 2013;24(5):469–75.

    Article  PubMed  Google Scholar 

  153. Wassall HJ, Devereux G, Seaton A, Barker RN. Complex effects of vitamin E and vitamin C supplementation on in vitro neonatal mononuclear cell responses to allergens. Nutrients. 2013;5(9):3337–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  154. Turner SW, Campbell D, Smith N, Craig LC, McNeill G, Forbes SH, et al. Associations between fetal size, maternal {alpha}-tocopherol and childhood asthma. Thorax. 2010;65(5):391–7.

    Article  PubMed  Google Scholar 

  155. Islam S, Narra V, Cote GM, Manganaro TF, Donahoe PK, Schnitzer JJ. Prenatal vitamin E treatment improves lung growth in fetal rats with congenital diaphragmatic hernia. J Pediatr Surg. 1999;34(1):172–6. discussion 6-7.

    Article  CAS  PubMed  Google Scholar 

  156. Erkkola M, Karppinen M, Javanainen J, Rasanen L, Knip M, Virtanen SM. Validity and reproducibility of a food frequency questionnaire for pregnant Finnish women. Am J Epidemiol. 2001;154(5):466–76.

    Article  CAS  PubMed  Google Scholar 

  157. West CE, Dunstan J, McCarthy S, Metcalfe J, D’Vaz N, Meldrum S, et al. Associations between maternal antioxidant intakes in pregnancy and infant allergic outcomes. Nutrients. 2012;4(11):1747–58.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  158. Maslova E, Hansen S, Strom M, Halldorsson TI, Olsen SF. Maternal intake of vitamins A, E and K in pregnancy and child allergic disease: a longitudinal study from the Danish National Birth Cohort. Br J Nutr. 2014;111(6):1096–108.

    Article  CAS  PubMed  Google Scholar 

  159. Leme AS, Hubeau C, Xiang Y, Goldman A, Hamada K, Suzaki Y, et al. Role of breast milk in a mouse model of maternal transmission of asthma susceptibility. J Immunol. 2006;176(2):762–9.

    Article  CAS  PubMed  Google Scholar 

  160. Fedulov AV, Kobzik L. Allergy risk is mediated by dendritic cells with congenital epigenetic changes. Am J Respir Cell Mol Biol. 2011;44:285–92.

    Article  CAS  PubMed  Google Scholar 

  161. Lim RH, Kobzik L. Transplacental passage of interleukins 4 and 13? PLoS One. 2009;4(3):e4660.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  162. Zourbas S, Dubanchet S, Martal J, Chaouat G. Localization of pro-inflammatory (IL-12, IL-15) and anti-inflammatory (IL-11, IL-13) cytokines at the foetomaternal interface during murine pregnancy. Clin Exp Immunol. 2001;126(3):519–28.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  163. Ostojic S, Dubanchet S, Chaouat G, Abdelkarim M, Truyens C, Capron F. Demonstration of the presence of IL-16, IL-17 and IL-18 at the murine fetomaternal interface during murine pregnancy. Am J Reprod Immunol. 2003;49(2):101–12.

    Article  CAS  PubMed  Google Scholar 

  164. Bowen JM, Chamley L, Mitchell MD, Keelan JA. Cytokines of the placenta and extra-placental membranes: biosynthesis, secretion and roles in establishment of pregnancy in women. Placenta. 2002;23(4):239–56.

    Article  CAS  PubMed  Google Scholar 

  165. Gregor H, Egarter C, Levin D, Sternberger B, Heinze G, Leitich H, et al. The passage of granulocyte-macrophage colony-stimulating factor across the human placenta perfused in vitro. J Soc Gynecol Investig. 1999;6(6):307–10.

    Article  CAS  PubMed  Google Scholar 

  166. Barrett EG, Rudolph K, Bowen LE, Bice DE. Parental allergic status influences the risk of developing allergic sensitization and an asthmatic-like phenotype in canine offspring. Immunology. 2003;110(4):493–500.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  167. van Rijt LS, Lambrecht BN. Dendritic cells in asthma: a function beyond sensitization. Clin Exp Allergy. 2005;35(9):1125–34.

    Article  PubMed  Google Scholar 

  168. Williams JW, Tjota MY, Clay BS, Vander Lugt B, Bandukwala HS, Hrusch CL, et al. Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation. Nat Commun. 2013;4:2990.

    Article  PubMed  CAS  Google Scholar 

  169. Abdala-Valencia H, Berdnikovs S, Soveg F, Cook-Mills JM. Alpha-tocopherol supplementation of allergic female mice inhibits development of CD11c+CD11b+ dendritic cells in utero and allergic inflammation in neonates. Am J Physiol Lung Cell Mol Physiol. 2014;307(6):L482–96.

    Google Scholar 

  170. Mikhaylova L, Zhang Y, Kobzik L, Fedulov AV. Link between epigenomic alterations and genome-wide aberrant transcriptional response to allergen in dendritic cells conveying maternal asthma risk. PLoS One. 2013;8(8):e70387.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  171. Lim RH, Arredouani MS, Fedulov A, Kobzik L, Hubeau C. Maternal allergic contact dermatitis causes increased asthma risk in offspring. Respir Res. 2007;8:56.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  172. Gerhold K, Avagyan A, Seib C, Frei R, Steinle J, Ahrens B, et al. Prenatal initiation of endotoxin airway exposure prevents subsequent allergen-induced sensitization and airway inflammation in mice. J Allergy Clin Immunol. 2006;118(3):666–73.

    Article  CAS  PubMed  Google Scholar 

  173. Gerhold K, Bluemchen K, Franke A, Stock P, Hamelmann E. Exposure to endotoxin and allergen in early life and its effect on allergen sensitization in mice. J Allergy Clin Immunol. 2003;112(2):389–96.

    Article  CAS  PubMed  Google Scholar 

  174. Tulic MK, Knight DA, Holt PG, Sly PD. Lipopolysaccharide inhibits the late-phase response to allergen by altering nitric oxide synthase activity and interleukin-10. Am J Respir Cell Mol Biol. 2001;24(5):640–6.

    Article  CAS  PubMed  Google Scholar 

  175. Gerhold K, Blumchen K, Bock A, Seib C, Stock P, Kallinich T, et al. Endotoxins prevent murine IgE production, T(H)2 immune responses, and development of airway eosinophilia but not airway hyperreactivity. J Allergy Clin Immunol. 2002;110:110–6.

    Article  CAS  PubMed  Google Scholar 

  176. Lima C, Souza VM, Faquim-Mauro EL, Hoshida MS, Bevilacqua E, Macedo MS, et al. Modulation of the induction of lung and airway allergy in the offspring of IFN-gamma-treated mother mice. J Immunol. 2005;175(6):3554–9.

    Article  CAS  PubMed  Google Scholar 

  177. Fedulov A, Silverman E, Xiang Y, Leme A, Kobzik L. Immunostimulatory CpG oligonucleotides abrogate allergic susceptibility in a murine model of maternal asthma transmission. J Immunol. 2005;175(7):4292–300.

    Article  CAS  PubMed  Google Scholar 

  178. de Brito CA, Fusaro AE, Victor JR, Rigato PO, Goldoni AL, Muniz BP, et al. CpG-induced Th1-type response in the downmodulation of early development of allergy and inhibition of B7 expression on T cells of newborn mice. J Clin Immunol. 2010;30(2):280–91.

    Article  PubMed  CAS  Google Scholar 

  179. Stoney RM, Woods RK, Hosking CS, Hill DJ, Abramson MJ, Thien FC. Maternal breast milk long-chain n-3 fatty acids are associated with increased risk of atopy in breastfed infants. Clin Exp Allergy. 2004;34(2):194–200.

    Article  CAS  PubMed  Google Scholar 

  180. Reichardt P, Muller D, Posselt U, Vorberg B, Diez U, Schlink U, et al. Fatty acids in colostrum from mothers of children at high risk of atopy in relation to clinical and laboratory signs of allergy in the first year of life. Allergy. 2004;59(4):394–400.

    Article  CAS  PubMed  Google Scholar 

  181. Miyake Y, Okubo H, Sasaki S, Tanaka K, Hirota Y. Maternal dietary patterns during pregnancy and risk of wheeze and eczema in Japanese infants aged 16–24 months: the Osaka Maternal and Child Health Study. Pediatr Allergy Immunol. 2011;22(7):734–41.

    Article  PubMed  Google Scholar 

  182. Verhasselt V, Milcent V, Cazareth J, Kanda A, Fleury S, Dombrowicz D, et al. Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma. Nat Med. 2008;14(2):170–5.

    Article  CAS  PubMed  Google Scholar 

  183. Mosconi E, Rekima A, Seitz-Polski B, Kanda A, Fleury S, Tissandie E, et al. Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development. Mucosal Immunol. 2010;3(5):461–74.

    Article  CAS  PubMed  Google Scholar 

  184. Lim R, Fedulov AV, Kobzik L. Maternal stress during pregnancy increases neonatal allergy susceptibility: role of glucocorticoids. Am J Physiol Lung Cell Mol Physiol. 2014;307(2):L141–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  185. Costa-Pinto FA, Basso AS, Britto LR, Malucelli BE, Russo M. Avoidance behavior and neural correlates of allergen exposure in a murine model of asthma. Brain Behav Immun. 2005;19(1):52–60.

    Article  CAS  PubMed  Google Scholar 

  186. Costa-Pinto FA, Basso AS, De Sa-Rocha LC, Britto LR, Russo M, Palermo-Neto J. Neural correlates of IgE-mediated allergy. Ann N Y Acad Sci. 2006;1088:116–31.

    Article  CAS  PubMed  Google Scholar 

  187. Portela Cde P, Massoco Cde O, de Lima WT, Palermo-Neto J. Stress-induced increment on total bronchoalveolar cell count in OVA-sensitized rats. Physiol Behav. 2001;72(3):415–20.

    Article  PubMed  Google Scholar 

  188. Portela CP, Leick-Maldonado EA, Kasahara DI, Prado CM, Calvo-Tiberio IF, Martins MA, et al. Effects of stress and neuropeptides on airway responses in ovalbumin-sensitized rats. Neuroimmunomodulation. 2007;14(2):105–11.

    Article  CAS  PubMed  Google Scholar 

  189. Portela Cde P, Tiberio Ide F, Leick-Maldonado EA, Martins MA, Palermo-Neto J. Effects of diazepam and stress on lung inflammatory response in OVA-sensitized rats. Am J Physiol Lung Cell Mol Physiol. 2002;282(6):L1289–95.

    Article  PubMed  Google Scholar 

  190. Tonelli LH, Katz M, Kovacsics CE, Gould TD, Joppy B, Hoshino A, et al. Allergic rhinitis induces anxiety-like behavior and altered social interaction in rodents. Brain Behav Immun. 2009;23(6):784–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  191. Lu Y, Liu M, Shi S, Jiang H, Yang L, Liu X, et al. Effects of stress in early life on immune functions in rats with asthma and the effects of music therapy. J Asthma. 2010;47(5):526–31.

    Article  CAS  PubMed  Google Scholar 

  192. Chida Y, Sudo N, Sonoda J, Hiramoto T, Kubo C. Early-life psychological stress exacerbates adult mouse asthma via the hypothalamus-pituitary-adrenal axis. Am J Respir Crit Care Med. 2007;175(4):316–22.

    Article  CAS  PubMed  Google Scholar 

  193. Strine TW, Mokdad AH, Balluz LS, Gonzalez O, Crider R, Berry JT, et al. Depression and anxiety in the United States: findings from the 2006 Behavioral Risk Factor Surveillance System. Psychiatr Serv. 2008;59(12):1383–90.

    Article  PubMed  Google Scholar 

  194. Cheung TK, Lam B, Lam KF, Ip M, Ng C, Kung R, et al. Gastroesophageal reflux disease is associated with poor asthma control, quality of life, and psychological status in Chinese asthma patients. Chest. 2009;135(5):1181–5.

    Article  PubMed  Google Scholar 

  195. Sansone RA, Sansone LA. Asthma: wheezing, woes, and worries. Psychiatry (Edgmont). 2008;5(10):48–52.

    Google Scholar 

  196. Di Marco F, Verga M, Santus P, Giovannelli F, Busatto P, Neri M, et al. Close correlation between anxiety, depression, and asthma control. Respir Med. 2010;104(1):22–8.

    Article  PubMed  Google Scholar 

  197. Cordina M, Fenech AG, Vassallo J, Cacciottolo JM. Anxiety and the management of asthma in an adult outpatient population. Ther Adv Respir Dis. 2009;3(5):227–33.

    Article  PubMed  Google Scholar 

  198. von Hertzen LC. Maternal stress and T-cell differentiation of the developing immune system: possible implications for the development of asthma and atopy. J Allergy Clin Immunol. 2002;109(6):923–8.

    Article  Google Scholar 

  199. Huang CC, Shih MC, Hsu NC, Chien Y, Chung BC. Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression. Endocrinology. 2012;153(10):4749–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  200. Norbiato G, Bevilacqua M, Vago T, Clerici M. Glucocorticoids and Th-1, Th-2 type cytokines in rheumatoid arthritis, osteoarthritis, asthma, atopic dermatitis and AIDS. Clin Exp Rheumatol. 1997;15(3):315–23.

    CAS  PubMed  Google Scholar 

  201. Ramirez F, Fowell DJ, Puklavec M, Simmonds S, Mason D. Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro. J Immunol. 1996;156(7):2406–12.

    CAS  PubMed  Google Scholar 

  202. Groer MW, Humenick S, Hill PD. Characterizations and psychoneuroimmunologic implications of secretory immunoglobulin A and cortisol in preterm and term breast milk. J Perinat Neonatal Nurs. 1994;7(4):42–51.

    Article  CAS  PubMed  Google Scholar 

  203. Murphy VE, Zakar T, Smith R, Giles WB, Gibson PG, Clifton VL. Reduced 11beta-hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma. J Clin Endocrinol Metab. 2002;87(4):1660–8.

    CAS  PubMed  Google Scholar 

  204. Murphy VE, Gibson PG, Giles WB, Zakar T, Smith R, Bisits AM, et al. Maternal asthma is associated with reduced female fetal growth. Am J Respir Crit Care Med. 2003;168(11):1317–23.

    Article  PubMed  Google Scholar 

  205. Shvedova AA, Kisin ER, Kagan VE, Karol MH. Increased lipid peroxidation and decreased antioxidants in lungs of guinea pigs following an allergic pulmonary response. Toxicol Appl Pharmacol. 1995;132:72–81.

    Article  CAS  PubMed  Google Scholar 

  206. Hardy CL, Rolland JM, O’Hehir RE. The immunoregulatory and fibrotic roles of activin A in allergic asthma. Clin Exp Allergy. 2015;45(10):1510–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  207. Hedger MP, Winnall WR, Phillips DJ, de Kretser DM. The regulation and functions of activin and follistatin in inflammation and immunity. Vitam Horm. 2011;85:255–97.

    Article  CAS  PubMed  Google Scholar 

  208. Sheikh A, Steiner MF, Cezard G, Bansal N, Fischbacher C, Simpson CR, et al. Ethnic variations in asthma hospital admission, readmission and death: a retrospective, national cohort study of 4.62 million people in Scotland. BMC Med. 2016;14(1):3.

    Article  PubMed  PubMed Central  Google Scholar 

  209. Kim HB, Zhou H, Kim JH, Habre R, Bastain TM, Gilliland FD. Lifetime prevalence of childhood eczema and the effect of indoor environmental factors: analysis in Hispanic and non-Hispanic white children. Allergy Asthma Proc. 2016;37(1):64–71.

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Herman B Wells Center for Pediatric Research, Department of Pediatrics, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA

    Joan M. Cook-Mills

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  1. University of Hohenheim, Institute of Nutritional Sciences, Stuttgart , Germany

    Peter Weber

  2. University of Applied Sciences Fulda, Nutritional, Food and Consumer Sciences, Fulda, Germany

    Marc Birringer

  3. Friedman School of Nutrition Science and Policy, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA

    Jeffrey B. Blumberg

  4. University Medical Center Groningen, Hanzeplain 1, Groningen, The Netherlands

    Manfred Eggersdorfer

  5. University of Hohenheim, Institute of Nutritional Sciences, Stuttgart , Germany

    Jan Frank

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Cook-Mills, J.M. (2019). The Impact of Vitamin E Isoforms on Asthma and Allergy. In: Weber, P., Birringer, M., Blumberg, J., Eggersdorfer, M., Frank, J. (eds) Vitamin E in Human Health. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-030-05315-4_25

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  • DOI: https://doi.org/10.1007/978-3-030-05315-4_25

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  • Print ISBN: 978-3-030-05314-7

  • Online ISBN: 978-3-030-05315-4

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