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Modulation of Glutathione Levels and Metabolism

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Anticarcinogenesis and Radiation Protection

Abstract

Glutathione (L-γ-glutamyl-L-cysteinyl-glycine), a tripeptide present in substantial concentrations in virtually all mammalian cells, plays a variety of roles in catalysis, metabolism, transport, and in cellular protection. A review of glutathione metabolism was presented at the first International Conference on Radioprotectors and Anticarcinogens (1); see also (2–6). A summary of glutathione metabolism is presented in Fig. 1. Understanding of the biochemistry of glutathione has led to procedures by which cellular levels of glutathione may be decreased or increased; glutathione metabolism may be modulated in other ways by selective inhibition of certain enzymes.

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Author information

Authors and Affiliations

  1. Cornell University Medical College, 1300 York Avenue, 10021, New York, N.Y., USA

    Alton Meister

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  1. Alton Meister
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Editors and Affiliations

  1. Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland

    Peter A. Cerutti

  2. Case Western Reserve University, Cleveland, Ohio, USA

    Oddvar F. Nygaard

  3. National Bureau of Standards, Gaithersburg, Maryland, USA

    Michael G. Simic

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© 1987 Plenum Press, New York

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Meister, A. (1987). Modulation of Glutathione Levels and Metabolism. In: Cerutti, P.A., Nygaard, O.F., Simic, M.G. (eds) Anticarcinogenesis and Radiation Protection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6462-1_55

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  • DOI: https://doi.org/10.1007/978-1-4615-6462-1_55

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6464-5

  • Online ISBN: 978-1-4615-6462-1

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