Anticarcinogenesis and Radiation Protection

  • Peter A. Cerutti
  • Oddvar F. Nygaard
  • Michael G. Simic

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Free Radical Mechanisms

    1. Michael G. Simic, Edward P. L. Hunter, Slobodan V. Jovanovic
      Pages 17-24
    2. Mohammed Al-Sheikhly, Michael G. Simic
      Pages 47-50
  3. Oxygen Species in Carcinogenesis

    1. Walter Kozumbo, Dominique Muehlematter, Takafumi Ochi, Peter Cerutti
      Pages 51-57
    2. Bruce W. Steinert, Bonnie F. Sloane, David G. Menter, John D. Crissman, John D. Taylor, Kenneth V. Honn
      Pages 63-69
    3. William E. M. Lands, Robert B. Pendleton
      Pages 81-84
    4. Janardan K. Reddy, M. Sambasiva Rao
      Pages 85-91
    5. E. Schneider, J. J. Watson, R. A. Floyd
      Pages 93-96
    6. Thomas A. Dahl, Philip E. Hartman, W. Robert Midden
      Pages 109-113
  4. Enzymatic Repair of DNA Damage

    1. Leona Samson, Patrick Carroll, Bruce Derfler, William Rebeck
      Pages 121-127

About this book


This book is based on the invited and contributed papers presented at the 2nd International Conference on Anticarcinogenesis and Radiation Protection held at the National Bureau of Standards, Gaithersburg, Maryland, USA, on March 8-12, 1987. The conference documented developments that have taken place in areas that were addressed during the first conference in 1982. A number of new topics, such as biological response modifiers, were included because of their emerging relevance to anticarcinogenesis and radiation protection. The organization of the material in this book does not follow the conference program; rather, we have attempted to provide a different sequence for didactic reasons. The aim of the conference, which is reflected in this book, was to promote further development of mechanistic approaches to cancer prevention and treatment based on recent progress in molecular biology and free radical chemistry. At the basis of carcinogenesis lie changes in the dynamics of growth and differentiation of specific cell subpopulations in the target tissue. 'These changes are brought about by selective toxicity and modulation of gene expression that are induced by xenobiotic carcinogens and affected by physiological and genetic factors. The book deals with oxidative stress and molecular damage caused by radiation and chemical pro-oxidants and their role in carcinogenesis, and it discusses mechanisms of deregulation of the expression of oncogenes and other genes involved in carcinogenic initiation and promotion.


cancer prevention carcinogenesis cell molecular biology prevention radiation protection

Editors and affiliations

  • Peter A. Cerutti
    • 1
  • Oddvar F. Nygaard
    • 2
  • Michael G. Simic
    • 3
  1. 1.Swiss Institute for Experimental Cancer ResearchLausanneSwitzerland
  2. 2.Case Western Reserve UniversityClevelandUSA
  3. 3.National Bureau of StandardsGaithersburgUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1988
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4615-6464-5
  • Online ISBN 978-1-4615-6462-1
  • About this book