Abstract
Peptidase enzymes are known to be widely distributed in plasma and tissues. As such, they are considered to play important roles in the local regulation of biologically active peptides, including peptide hormones, growth factors, and cytokines. In the uterine endometrium, it has been suggested that some peptidase enzymes in the endometrial epithelium play an important role in blastocyst implantation. In rabbits, the uterine epithelium undergoes extensive morphological change during the peri-implantation phase, and dynamic changes in aminopeptidase and dipeptidyl peptidase IV activities on the surface of endometrial epithelial cells have been reported in histochemical experiments (Classen-Linke et al., 1987). Furthermore, proteinase inhibitors have been shown to block implantation in rabbits (Denker, 1977). In humans, we have reported that the cluster of differentiation (CD) antigens, CD10 and CD13, were expressed in the endometrial stromal cells, and that CD26 antigens were localized in the glandular epithelial cells (Imai et al., 1992a, 1992b). CD10, CD13, and CD26 antigens were shown to be identical to neutral endopeptidase (NEP) (Letarte et al, 1988), aminopeptidase N (APN) (Look et al. 1989), and dipeptidyl peptidase IV (DPP IV) (Mattern et al., 1989; Stein et al., 1989;Ulmer et al., 1990) respectively, all of which are cell surface peptidases. Since a variety of peptide factors, including peptide hormones, growth factors, and cytokines, have been suggested to play important roles in regulating endometrial cell proliferation/differentiation, these peptidase enzymes are thought to be involved in the regulation of human endometrial function and the implantation process.
Chapter PDF
Similar content being viewed by others
Keywords
- Dipeptidyl Peptidase
- Human Endometrium
- Endometrial Stromal Cell
- Uterine Epithelium
- Aminopeptidase Activity
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Amoscato, A.A., Alexander, J.R. and Babcock, G.F., 1989, Surface aminopeptidase activity of human lymphocytes. I. Biochemical and biologic properties of intact cells, J. Immunol. 142:1245.
Classen-Linke, I., Denker, H.W. and Winterhager, E., 1987, Apical plasma membrane-bound enzymes of rabbit uterine epithelium; pattern changes during the periimplantation phase, Histochemistry 87:517.
Dang, N.H., Torimoto, Y., Schlossman, S.F. and Morimoto, C., 1990, Human CD4 helper T cell activation: functional involvement of two distinct collagen receptors 1F7 and VLA integrin family, J. Exp. Med. 172:649.
Delmas, B., Gelfi J., L’Haridon R., Vogel L.K., Sjöström H., Nóren, O. and Laude, H., 1992, Aminopeptidase N is a major receptor for the enteropathogenic coronavirus TGEV, Nature 357:417.
Denker, H.W., 1977, Implantation. The role of proteinases, and blockage of implantation by proteinase inhibitors, Adv. Anat. Embryol. Cell Biol. 53 Fasc 5.
Erdös, E.G. and Skidgel, R.A., 1989, Neutral endopeptidase 24-11 (enkephalinase) and related regulators of peptide hormones, FASEB J. 3:145.
Hanski, C., Huhle, T. and Reutter, W., 1985, Involvement of plasma membrane dipeptidyl peptidase IV in fibronectin-mediated adhesion of cells on collagen, Biol. Biochem. Hoppe-Seyler 366:1169.
Hanski, C., Huhle, T., Gossrau, R. and Reutter, W., 1988, Direct evidence for the binding of rat liver DPP IV to collagen in vitro, Exp. Cell Res. 176:64.
Imai, K., Maeda, M., Fujiwara, H., Okamoto, N., Kariya, M., Emi, N., Takakura, K., Kanzaki, H. and Mori, T., 1992a, Human endometrial stromal cells and decidual cells express cluster of differentiation (CD) 13 antigen/aminopeptidase N and CD10 antigen/neutral endopeptidase, Biol. Reprod. 46:328.
Imai, K., Maeda, M., Fujiwara, H., Kariya, M., Takakura, K., Kanzaki, H. and Mori, T., 1992b, Dipeptidyl peptidase IV as a differentiation marker of the human endometrial glandular cells. Hum. Reprod. 7:1189.
Kariya, M., Kanzaki, H., Takakura, K., Imai, K., Okamoto, N., Emi, N., Kariya, Y. and Mori, T., 1991, Interleukin-1 inhibits in vitro decidualization of human endometrial stromal cells, J. Clin. Endocrinol. Metab. 73:1170.
Letarte, M., Vera, S., Tran, R., Addis, J.B.L., Onizuka, R.J. and Quackenbush, E.J., 1988, Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase, J. Exp. Med. 168:1247.
Lodja, Z., 1979, Studies on dipeptidyl(amino)peptidase IV (glycyl-proline naphthylamidase). II. Blood vessels, Histochemistry 54:153.
Look, A.T., Ashmun, R.A., Shapiro, L.H. and Peiper, S.C., 1989, Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N, J. Clin. Invest. 83:1299.
Mattern, T., Fled, H.D., Feller, A.C., Heymann, E. and Ulmer, A.J., 1989, Anti-DPP-IV and anti-Tal but not IOT 15 should be clustered in CDw26, in: “Leukocyte Typing IV. White Cell Differentiation Antigens. Oxford,” Knapp, W., Dörken, B., Gilks, W.R., Rieber, E.P., Schmidt, R.E., Stein, H. and von den Borne, A.E.G.K., eds. University Press, Oxford, New York, Tokyo.
Nausch, I., Mentlein, R. and Heymann, E., 1990, The degradation of bioactive peptides and proteins by dipeptidyl peptidase IV from human placenta, Biol. Chem. Hoppe-Seyler 371:1113.
Piazza, G.A., Callanan, H.M., Mowery, J. and Hixson, D.C., 1989, Evidence for a role of dipeptidyl peptidase IV in fibronectin-mediated interactions of hepatocytes with extracellular matrix, Bioch. J. 262:327.
Püschel, G., Mentlein, R. and Heymann, E., 1982, Isolation and characterization of dipeptidyl peptidase IV from human placenta, Eur. J. Biochem. 126:359.
Sidorowicz, W., Zownir, O. and Behahl, F.J., 1981, Action of human pancreas alanine aminopeptidase on biologically active peptides:kinin converting activity, Clin. Chem. Acta. 111:69.
Stein, H., Schwarting, R. and Niedobitek, G., 1989, Cluster Report:CD26, in: “Leukocyte Typing IV. White Cell Differentiation Antigens. Oxford,” Knapp, W., Dörken, B., Gilks, W.R., Rieber, E.P., Schmidt, R.E., Stein, H. and von den Borne, A.E.G.K., eds. University Press, Oxford, New York, Tokyo.
Ulmer, A.J., Mattern, T., Feller, A.C., Heymann, E. and Flad, H.D., 1990, CD26 antigen is a surface dipeptidyl peptidase IV (DPP IV) as characterized by monoclonal antibodies clone TII-19-4-7 and 4EL1C7, Scand. J. Immunol. 31:429.
Ward, P.E., Benter, I.F., Dick, L. and Wilk, S., 1990, Metabolism of vasoactive peptides by plasma and purified renal aminopeptidase M, Biochem. Pharmacol. 40:1725.
Yeager, C.L., Ashmun, R.A., Williams, R.K., Cardellichio, C.B., Shapiro, L.H., Look, A.T. and Holmes, K.V., 1992, Human aminopeptidase N is a receptor for human coronavirus 229E, Nature 357:420.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Kanzaki, H., Imai, K., Fujiwara, H., Maeda, M., Mori, T. (1994). The Expression of Peptidase Antigens, CD10/Neutral Endopeptidase, CD13/Aminopeptidase N, and CD26/Dipeptidyl Peptidase IV in Human Endometrium. In: Glasser, S.R., Mulholland, J., Psychoyos, A. (eds) Endocrinology of Embryo-Endometrium Interactions. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1881-5_7
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1881-5_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5766-7
Online ISBN: 978-1-4615-1881-5
eBook Packages: Springer Book Archive