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Gadd45 in Stress Signaling, Cell Cycle Control, and Apoptosis

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Gadd45 Stress Sensor Genes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 793))

Abstract

The first identified Gadd45 gene, Gadd45a, encodes a ubiquitously expressed protein that is often induced by DNA damage and other stress signals associated with growth arrest and apoptosis. This protein and the other two members of this small gene family, Gadd45b and Gadd45g, have been implicated in a variety of the responses to cell injury including cell cycle checkpoints, apoptosis, and DNA repair. In vivo, many of the prominent roles for the Gadd45 proteins are associated with signaling mediated by p38 mitogen-activated protein kinases (MAPK). Gadd45 proteins can contribute to p38 activation either by activation of upstream kinase(s) or by direct interaction. In vivo, there are important tissue and cell-type-specific differences in the roles for Gadd45 in MAPK signaling. In addition to being p53-regulated, Gadd45a has been found to contribute to p53 activation via p38. Like other stress and signaling proteins, Gadd45 proteins show complex regulation and numerous effectors.

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Authors and Affiliations

  1. Department of Immunology and Oncology, Centro Nacional de Biotecnología, (CNB-CSIC) Lab 417, c/Darwin n 3, Campus Cantoblanco, 28049, Madrid, Spain

    Jesús M. Salvador

  2. Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC, USA

    Joshua D. Brown-Clay & Albert J. Fornace Jr. M.D.

  3. Lombardi Comprehensive Cancer Center, Georgetown University, Research Building, Room E504, 3970 Reservoir Road, Washington, DC, 20057-1468, USA

    Albert J. Fornace Jr. M.D.

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  1. Jesús M. Salvador
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  2. Joshua D. Brown-Clay
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  3. Albert J. Fornace Jr. M.D.
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Correspondence to Albert J. Fornace Jr. M.D. .

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Editors and Affiliations

  1. Professor of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Dan A. Liebermann

  2. Professor of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Barbara Hoffman

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Salvador, J.M., Brown-Clay, J.D., Fornace, A.J. (2013). Gadd45 in Stress Signaling, Cell Cycle Control, and Apoptosis. In: Liebermann, D., Hoffman, B. (eds) Gadd45 Stress Sensor Genes. Advances in Experimental Medicine and Biology, vol 793. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8289-5_1

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