Overview
- Editors:
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Wolfgang Walther
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Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
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Ulrike Stein
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Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
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Table of contents (39 protocols)
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Clinical Protocols for Cancer Gene Therapy
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- Friedrich Weber, Frank Floeth, Hans Bojar
Pages 499-509
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- Giorgio Palù, Massimo Pizzato, Roberta Bonaguro, Federico Colombo
Pages 511-522
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- Hardev S. Pandha, Nicholas R. Lemoine
Pages 523-534
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Clinical Protocols for Cancer Gene Therapy
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Front Matter
Pages 437-616
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- Gary L. Clayman, Douglas K. Frank, Patricia A. Bruso
Pages 537-544
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- Ragai R. Mitry, Nagy A. Habib
Pages 545-558
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Clinical Protocols for Cancer Gene Therapy
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Front Matter
Pages 437-616
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- Patrice S. Obermiller, Jeffrey T. Holt
Pages 593-607
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- Shrinavassan Shrimdkandada, Si Qing Fu, Lian Hua Yin, Xiang Yang David Guo, Thong Nanakorn, Xue Yan Peng et al.
Pages 609-616
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Back Matter
Pages 617-645
About this book
Since the discovery of the molecular structure of genes and the unveiling of the molecular basis of numerous human diseases, scientists have been fas- nated with the possibility of treating certain diseases by transducing foreign DNA into the affected cells. Initially, it was proposed that the foreign DNA could either replace defective nonfunctional genes, or code for therapeutic proteins. This concept has evolved into the rapidly growing field of gene therapy. Even though surgery, radiotherapy, and chemotherapy are widely ava- able and routinely used for cancer treatment, these therapies fail to cure approximately 50 percent of cancer patients. Therefore, since it is a disease characterized by aberrant gene expression, cancer has been a target of gene therapy research since the inception of this treatment modality. Numerous cancer gene therapy strategies are currently being investigated, including gene replacement therapy, the regulation of gene expression to modulate immu- logical responses to tumors, the direct killing of tumor cells, and direct int- ference with tumor growth. In this context, gene transfer systems, tumor-specific expression vectors, and novel therapeutic genes have been extensively st- ied. All these strategies aim for the selective destruction of human malignant disease while circumventing the destruction of nonmalignant cells and tissues thereby minimizing toxicity to the patient.
Reviews
"A wide variety of methods used to deliver genes to tumors are discussed, as are the type of genes used. This includes tumor vaccination, suicide genes, antisense genes, ribozymes, etc. The unique aspect of this book is the translational approach of explaining laboratory techniques as well as the application to patients. . .This book is well written and a translational resource for those interested in the rapidly advancing and novel field of gene therapy for malignancies."-Doody's Health Science Book Review Journal