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Deciphering Drug Targets for Alzheimer’s Disease

  • Book
  • © 2023

Overview

Editors:
  1. Dileep Kumar

    1. Department of Entomology and Nematology, UC Davis Comprehensive Cancer Center, University of California, Davis, USA

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  2. Vaishali M. Patil

    1. Department of Pharmaceutical Chemistry, KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad, India

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  3. Dee Wu

    1. Department of Radiological Sciences, Section of Medical Physics, University of Oklahoma, Norman, USA

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  4. Nanasaheb Thorat

    1. Nuffield Department of Women’s & Reproductive Health, University of Oxford, Oxford, UK

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  • Summarizes the latest research on Alzheimer's Disease

  • Explains fundamental characteristics and biofunctionality of Alzheimer’s Disease drug targets

  • Provides latest information to use novel drug targets and create efficient new drug targeting, transport methods

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xv
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  2. Deciphering New Drug Targets in Alzheimer’s Disease

    • Nitin Verma, Komal Thapa, Neha Kanojia, Gagandeep Kaur, Parul Sood, Kamal Dua
    Pages 1-18

  3. Novel Therapeutic Targets for Treating Alzheimer’s Disease

    • Magham Sai Varshini, Ammu V. V. V. Ravi Kiran, Kusuma Kumari Garikapati, Praveen Thaggikuppe Krishnamurthy, Vaishali M. Patil, Renat R. Khaydarov
    Pages 19-39

  4. Modified Investigation Tools and Techniques Useful in Alzheimer’s Disease Research

    • Sharada L. Deore, Bhushan Baviskar, Anjali A. Kide, Somshekhar S. Khadabadi, Bhavana A. Shende
    Pages 41-67

  5. Dual Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) Inhibitors: The Quest for a Disease-Modifying Treatment for Alzheimer’s Disease

    • Sukanya, Bhupendra G. Prajapati, Vaishali M. Patil, Bhanwar Singh Choudhary
    Pages 69-94

  6. β-Secretase as a Primary Drug Target of Alzheimer Disease: Function, Structure, and Inhibition

    • Saroj Verma, Debashish Paramanick
    Pages 95-109

  7. Endocrine Receptors: The Potential Therapeutic Targets for Alzheimer’s

    • Tabassum Zafar, Ab Qayoom Naik, Bashirulla Shaik
    Pages 111-124

  8. Calcium Channels as a Potential Therapeutic Target for Alzheimer’s Disease

    • Poonam Sharma, Princi Thapak, Bhawana Chandwani, Harsha Kharkwal, G. T. Kulkarni, Rajendra Awasthi et al.
    Pages 125-149

  9. Traversing Through the Trajectory of Pathogenic Astrocytes in Alzheimer’s Disease

    • Gadde Shareena, Dileep Kumar, Dee Wu
    Pages 151-180

  10. Targeting Mitochondrial Dynamics as a Restorative Approach in the Treatment of Alzheimer’s Disease

    • Ruchi Pandey, Priya Bisht, Anita Kumari, Adarsh Ray, V. Ravichandiran, Nitesh Kumar
    Pages 181-197

  11. Epigenetic Therapy for Alzheimer’s Disease

    • Sonam Fathima Mehak, Vikas Sahu, Apoorva Bettagere Shivakumar, Gireesh Gangadharan, Shama Prasada Kabekkodu
    Pages 199-217

  12. Exploring the Diverse Roles of GSK-3β Kinase in Alzheimer’s Disease

    • Gadde Shareena, Dileep Kumar, Nanasaheb Thorat
    Pages 219-244

  13. Role of Target Fishing in Discovery of Novel Anti-Alzheimer’s Agents: In Silico Applications

    • Anjali Murmu, Balaji Wamanrao Matore, Purusottam Banjare, Nilesh Kumar Pandey, Nikita Chhabra, Lomash Banjare et al.
    Pages 245-284

  14. Multi-Target-Directed Ligand Approach in Anti-Alzheimer’s Drug Discovery

    • Vaishali M. Patil, Neeraj Masand, Vertika Gautam, Shikha Kaushik, Dee Wu
    Pages 285-319

  15. Exploring the Role of Tau Proteins in Alzheimer’s Disease from Typical Functioning MAPs to Aberrant Fibrillary Deposits in the Brain

    • Gadde Shareena, Dileep Kumar
    Pages 321-349

  16. The Overview of Drugs Used in Alzheimer’s Disease and Their Molecular Targets

    • Sukriti Vishwas, Monica Gulati, Malakapogu Ravindra Babu, Ankit Awasthi, Rajan Kumar, Rubiya Khursheed et al.
    Pages 351-376

  17. Back Matter

    Pages 377-381
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Keywords

About this book

This book explains the fundamental characteristics and biofunctionality of Alzheimer’s Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimer’s Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimer’s disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimer’s disease treatment.

Editors and Affiliations

  • Department of Entomology and Nematology, UC Davis Comprehensive Cancer Center, University of California, Davis, USA

    Dileep Kumar

  • Department of Pharmaceutical Chemistry, KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad, India

    Vaishali M. Patil

  • Department of Radiological Sciences, Section of Medical Physics, University of Oklahoma, Norman, USA

    Dee Wu

  • Nuffield Department of Women’s & Reproductive Health, University of Oxford, Oxford, UK

    Nanasaheb Thorat

About the editors

Dr. Dileep Kumar 
Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharti Vidyapeeth University, India


Dr. Vaishali M. Patil 
KIET School of Pharmacy, KIET Group of Institutions, Uttar Pradesh, India


Dr. Dee Wu
Department of Radiological Sciences, Section of Med Physics
Medical Physics Education Program


Dr. Nanasaheb Thorat
University of Oxford, Medical Science Division
Nuffield Department of Women's & Reproductive Health

Bibliographic Information

  • Book Title: Deciphering Drug Targets for Alzheimer’s Disease

  • Editors: Dileep Kumar, Vaishali M. Patil, Dee Wu, Nanasaheb Thorat

  • DOI: https://doi.org/10.1007/978-981-99-2657-2

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023

  • Hardcover ISBN: 978-981-99-2656-5Published: 01 September 2023

  • Softcover ISBN: 978-981-99-2659-6Due: 15 September 2024

  • eBook ISBN: 978-981-99-2657-2Published: 31 August 2023

  • Edition Number: 1

  • Number of Pages: XV, 381

  • Number of Illustrations: 1 b/w illustrations

  • Topics: Biomedicine, general, Life Sciences, general, Neurosciences, Biotechnology, Biotechnology

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