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© 2019

In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials

  • Toru Takebayashi
  • Robert Landsiedel
  • Masashi Gamo
Book

Table of contents

  1. Front Matter
    Pages i-vi
  2. Robert Landsiedel, Masashi Gamo, Akihiko Hirose
    Pages 1-21
  3. Short-Term Inhalation Study

  4. Intratracheal Administration Study

    1. Front Matter
      Pages 93-93
    2. Yukiko Yoshiura, Yuri Fujisawa, Taisuke Tomonaga, Hiroto Izumi, Takako Oyabu, Toshihiko Myojo et al.
      Pages 95-105
    3. Toshio Kobayashi, Yutaka Oshima, Yasuhiro Tsubokura, Takakazu Kayashima, Makoto Nakai, Nobuya Imatanaka et al.
      Pages 107-122
    4. Kenji Kawaguchi, Kenji Koga, Takeshi Sasaki
      Pages 123-144
    5. Yutaka Oshima, Toshio Kobayashi, Takakazu Kayashima, Makoto Nakai, Nobuya Imatanaka
      Pages 165-192

About this book

Introduction

This edited volume discusses the short-term inhalation study (STIS) and intratracheal administration, the two major in vivo inhalation-toxicity screening methods, which play an important role in efficient hazard evaluation. It also provides a general overview of the inhalation toxicity of nanomaterials and related issues. For each screening method, it provides up-to-date information on the test procedures, interpretation of the test results, useful applications, and related technologies. In view of the increasing variety of nanomaterials in practical use, the book offers a basis for building a framework for grouping and read-across assessments of nanomaterials.

With contributions by academic and industrial experts, In vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials is a pragmatic reference resource for readers who are responsible for assessing the safety of nanomaterials in R&D and business, as well as researchers.


Keywords

Short-Term Inhalation Study STIS Initial Hazard Data Pulmonary Bioassay Intratracheal Administration Hazard Evaluation

Editors and affiliations

  • Toru Takebayashi
    • 1
  • Robert Landsiedel
    • 2
  • Masashi Gamo
    • 3
  1. 1.Graduate School of Health ManagementKeio UniversityFujisawaJapan
  2. 2.Experimental Toxicology and EcologyBASF SELudwigshafen am RheinGermany
  3. 3.National Institute of Advanced Industrial Science and Technology (AIST)TsukubaJapan

About the editors

Toru Takebayashi
Keio University
Graduate School of Health Management
Fujisawa, Kanagawa, Japan

Robert Landsiedel
BASF SE
Experimental Toxicology and Ecology
Ludwigshafen am Rhein, Germany


Masashi Gamo
National Institute of Advanced Industrial Science and Technology (AIST)
Tsukuba, Ibaraki, Japan


Bibliographic information

  • Book Title In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials
  • Editors Toru Takebayashi
    Robert Landsiedel
    Masashi Gamo
  • Series Title Current Topics in Environmental Health and Preventive Medicine
  • Series Abbreviated Title Current Topics in Environmental Health and Preventive Medicine
  • DOI https://doi.org/10.1007/978-981-13-8433-2
  • Copyright Information Springer Nature Singapore Pte Ltd. 2019
  • Publisher Name Springer, Singapore
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-981-13-8432-5
  • Softcover ISBN 978-981-13-8435-6
  • eBook ISBN 978-981-13-8433-2
  • Series ISSN 2364-8333
  • Series E-ISSN 2364-8341
  • Edition Number 1
  • Number of Pages VI, 223
  • Number of Illustrations 8 b/w illustrations, 62 illustrations in colour
  • Topics Health Promotion and Disease Prevention
    Health Administration
    Pharmacology/Toxicology
  • Buy this book on publisher's site

Reviews

“This will be a useful reference for those responsible for assessing the safety of nanomaterials in both research and development and commercial endeavors. … The success of this monograph will be measured by the acceptance of S-T-I-S and intratracheal studies by regulators.” (John T. Pierce, Doody’s Book Reviews, April 10, 2020)