Overview
- Comprehensive description and comparison of tumor ablation methods
- Conceptual and practical aspects of cancer immunotherapy
- Combination treatments of cancer
Part of the book series: The Tumor Microenvironment (TTME, volume 5)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
About this book
The growing knowledge on tumor-immune response interactions and on the tumor microenvironment did not translate so far into better control of cancer by anti-tumor vaccination. The percentage of patients who benefited from vaccination strategies is still too small to justify their general use. It is the aim of this book to present an alternative to the conventional approach of developing injected tumor vaccines to activate anti-tumor immunity, which will fight cancer. It is argued that in situ tumor ablation (destruction) that involves tumor antigen release; cross presentation and the release of danger associated molecular patterns (DAMPs) can make the tumor its own cellular vaccine.
Tumor ablation methods using chemicals, radiation, photodynamic therapy, cryoablation, high-temperature, radiofrequency, high intensity focused ultrasound, and electric-based ablation have been developed for focal tumors. In this book experts will deal with two main topics: I. What are the principles of the various ablation modalities, and II. How each method affects the tumor cells and their microenvironment, and how these effects are responsible for the induction of specific anti-tumor immunity.
The aims of this book are thus: 1. Familiarize the readers with various methods of in situ tumor ablation. 2. Review the literature and stimulate comparisons on the efficacy of different ablation methods for the treatment of tumors of different histotypes. 3. Review the literature on the effects of various ablation methods on systemic and local anti tumor immunity and on other manifestations of the interactions of tumors with their microenvironment. 4. Stimulate comparative studies on the immunostimulatory effects of different ablation modalities.
Similar content being viewed by others
Keywords
Table of contents (8 chapters)
Editors and Affiliations
Bibliographic Information
Book Title: Tumor Ablation
Book Subtitle: Effects on Systemic and Local Anti-Tumor Immunity and on Other Tumor-Microenvironment Interactions
Editors: Yona Keisari
Series Title: The Tumor Microenvironment
DOI: https://doi.org/10.1007/978-94-007-4694-7
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media Dordrecht 2013
Hardcover ISBN: 978-94-007-4693-0Published: 10 August 2012
Softcover ISBN: 978-94-007-9932-5Published: 21 September 2014
eBook ISBN: 978-94-007-4694-7Published: 15 August 2012
Edition Number: 1
Number of Pages: XII, 156
Topics: Biomedicine general, Cancer Research, Oncology, Immunology, Radiotherapy