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Clinical Aspects of Microdialysis

  • Conference proceedings
  • © 1996

Overview

Editors:
  1. Aminadav Mendelowitsch

    1. University Neurosurgical Clinic, Kantonsspital Basel, Basel, Switzerland

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  2. Helen Langemann

    1. Department of Research, Kantonsspital Basel, Basel, Switzerland

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  3. Beat Alessandri

    1. Department of Research, Kantonsspital Basel, Basel, Switzerland

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  4. Hans Landolt

    1. Neurosurgical Clinic, Kantonsspital Aarau, Aarau, Switzerland

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  5. Otmar Gratzl

    1. University Neurosurgical Clinic, Kantonsspital Basel, Basel, Switzerland

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Part of the book series: Acta Neurochirurgica Supplement (NEUROCHIRURGICA, volume 67)

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About this book

Microdialysis is a minimally invasive method which enables continuous monitoring of parameters in the extracellular space of various tissues. It has been investigated in animal models for over a decade, and many publications have provided insight into its advantages and disadvantages. However, in spite of its enormous potential for revealing metabolic processes in normal and pathological tissue, microdialysis in humans is still in its infancy. Clinical neurointensive medicine nowadays demands much more than conventional monitoring methods. As already shown by jugular bulb measurements of oxygen and lactate, in the future clinicians will want to have access to continuous neurochemical information from the patient. This information could be used to prevent those enigmatic secondary lesions which play such a negative role in neurointensive medicine, or at least enable treatment of them at an early stage. The extensive information now available from the laboratory would help with the interpretation of clinical analogues. In the University Clinic of Neurosurgery in Basel we have been involved in the field of micro dialytic monitoring for several years and have recognised the problems, both technical and ethical, which are involved in taking the difficult step from animal experiments to clinical application. In 1994 we thought that research on clinical microdialysis had reached the stage which would enable scientists and clinicians to have many fruitful discussions.

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Table of contents (16 papers)

  1. Front Matter

    Pages I-VIII
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  2. Basic Science and Methodology

    1. Possible Glial Contribution of Rat Hippocampus Lactate as Assessed with Microdialysis and Stress

      • O. Elekes, K. Venema, F. Postema, R. Dringen, B. Hamprecht, J. Korf
      Pages 1-5

    2. Application of Glutamate in the Cortex of Rats: A Microdialysis Study

      • B. Alessandri, H. Landolt, H. Langemann, J. Gregorin, J. Hall, O. Gratzl
      Pages 6-12

    3. Clinical Microdialysis: The Role of On-line Measurement and Quantitative Microdialysis

      • Martyn G. Boutelle, M. Fillenz
      Pages 13-20

    4. Intracerebral Microdialysis Markedly Inhibits the Propagation of Cortical Spreading Depression

      • Tihomir P. Obrenovitch, E. Zilkha
      Pages 21-23

    5. Delayed Neuronal Damage Following Focal Ischemic Injury in Stroke-Prone Spontaneously Hypertensive Rats

      • Katsuji Shima, T. Shirotani, H. Chigasaki
      Pages 24-27

    6. The Measurement of Extracellular Inorganic Phosphate Gives a More Reliable Indication for Severe Impairment of Cerebral Cell Function and Cell Death than the Measurement of Extracellular Lactate

      • D. Scheller, J. Kolb, U. Peters, F. Tegtmeier
      Pages 28-30

  3. Clinical Investigations

    1. A Concept for the Introduction of Cerebral Microdialysis in Neurointensive Care

      • H. Landolt, H. Langemann, B. Alessandri
      Pages 31-36

    2. Lactic Acid and Amino Acid Fluctuations Measured Using Microdialysis Reflect Physiological Derangements in Head Injury

      • J. Clay Goodman, S. P. Gopinath, A. B. Valadka, R. K. Narayan, R. G. Grossman, R. K. Simpson Jr. et al.
      Pages 37-39

    3. Glutamate Release and Cerebral Blood Flow After Severe Human Head Injury

      • Alois Zauner, R. Bullock, A. J. Kuta, J. Woodward, H. F. Young
      Pages 40-44

    4. Increased Levels of Glutamate in Patients with Subarachnoid Haemorrhage as Measured by Intracerebral Microdialysis

      • O. G. Nilsson, H. Säveland, F. Boris-Möller, L. Brandt, T. Wieloch
      Pages 45-47

    5. Microdialytic Monitoring of the Cortex During Neurovascular Surgery

      • A. Mendelowitsch, H. Langemann, B. Alessandri, A. Kanner, H. Landolt, O. Gratzl
      Pages 48-52

    6. In-vivo Microdialysis Study of Extracellular Glutamate Response to Temperature Variance in Subarachnoid Hemorrhage

      • Ashfaq Shuaib, R. Kanthan, G. Goplen, R. Griebel, H. El-Azzouni, H. Miyashita et al.
      Pages 53-58

    7. Antiepileptic Drug Pharmacokinetics in Patients with Epilepsy Using a New Microdialysis Probe: Preliminary Observations

      • P. N. Patsalos, M. T. O’Connell, H. C. Doheny, J. W. A. S. Sander, S. D. Shorvon
      Pages 59-62

    8. A New Screwing Device for Fixing a Microdialysis Probe in Critical Care Patients

      • Andrew A. Kanner, A. Mendelowitsch, H. Langemann, B. Alessandri, O. Gratzl
      Pages 63-65

    9. A Novel Microdialysis Probe Designed for Clinical Use: Potential Analytical and Therapeutic Applications

      • John C. Lehmann, T. R. Jones, P. K. Mishra, S. Hamelin, S. N. Nair
      Pages 66-69

    10. Microdialytic Monitoring During a Cardiovascular Operation

      • H. Langemann, J. Habicht, A. Mendelowitsch, A. Kanner, B. Alessandri, H. Landolt et al.
      Pages 70-74

  4. Back Matter

    Pages 75-75
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Editors and Affiliations

  • University Neurosurgical Clinic, Kantonsspital Basel, Basel, Switzerland

    Aminadav Mendelowitsch, Otmar Gratzl

  • Department of Research, Kantonsspital Basel, Basel, Switzerland

    Helen Langemann, Beat Alessandri

  • Neurosurgical Clinic, Kantonsspital Aarau, Aarau, Switzerland

    Hans Landolt

Bibliographic Information

  • Book Title: Clinical Aspects of Microdialysis

  • Editors: Aminadav Mendelowitsch, Helen Langemann, Beat Alessandri, Hans Landolt, Otmar Gratzl

  • Series Title: Acta Neurochirurgica Supplement

  • DOI: https://doi.org/10.1007/978-3-7091-6894-3

  • Publisher: Springer Vienna

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag/Wien 1996

  • Softcover ISBN: 978-3-7091-7426-5Published: 26 September 2011

  • eBook ISBN: 978-3-7091-6894-3Published: 06 December 2012

  • Series ISSN: 0065-1419

  • Series E-ISSN: 2197-8395

  • Edition Number: 1

  • Number of Pages: VIII, 75

  • Topics: Otorhinolaryngology, Neurosurgery

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