Overview
- Editors:
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Marina V. Rodnina
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Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany
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Wolfgang Wintermeyer
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Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany
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Rachel Green
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Howard Hughes Medical Institute Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, USA
- First ribosome book since 2001
- Nobel Prize Chemistry 2009 - The Ribosome
- Includes chapters of all three Nobel Prize winners
- Comprehensive in scope
- Includes supplementary material: sn.pub/extras
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Table of contents (33 chapters)
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Decoding, fidelity, and peptidyl transfer
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- Rodrigo F. Ortiz-Meoz, Shan L. He, Hani S. Zaher, Rachel Green
Pages 213-223
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- Magnus Johansson, Ka Weng Ieong, Johan Åqvist, Michael Y. Pavlov, Måns Ehrenberg
Pages 225-235
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- Sean P. McClory, Aishwarya Devaraj, Daoming Qin, Joshua M. Leisring, Kurt Fredrick
Pages 237-247
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- Rashid Akbergenov, Dmitry Shcherbakov, Tanja Matt, Stefan Duscha, Martin Meyer, Déborah Perez Fernandez et al.
Pages 249-261
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- Biswajoy Roy-Chaudhuri, Narayanaswamy Kirthi, Teresa Kelley, Gloria M. Culver
Pages 263-270
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Elongation and ribosome dynamics
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Front Matter
Pages 271-271
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- Daniel D. MacDougall, Ruben L. Gonzalez Jr.
Pages 273-293
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- Sotaro Uemura, Joseph D. Puglisi
Pages 295-302
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- P. C. Whitford, R. B. Altman, P. Geggier, D. S. Terry, J. B. Munro, J. N. Onuchic et al.
Pages 303-319
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- Wolfgang Wintermeyer, Andreas Savelsbergh, Andrey L. Konevega, Frank Peske, Vladimir I. Katunin, Yuri P. Semenkov et al.
Pages 329-338
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- Barry S. Cooperman, Yale E. Goldman, Chunlai Chen, Ian Farrell, Jaskarin Kaur, Hanqing Liu et al.
Pages 339-348
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- Harry F. Noller, Dmitri N. Ermolenko, Andrei Korostelev, Martin Laurberg, Jianyu Zhu, Haruichi Asahara et al.
Pages 349-360
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- David Healey, Mickey Miller, Christopher Woolstenhulme, Allen Buskirk
Pages 361-373
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Nascent peptide and tunnel interactions
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Front Matter
Pages 375-375
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- Nora Vázquez-Laslop, Haripriya Ramu, Alexander Mankin
Pages 377-392
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- Daniel N. Wilson, Shashi Bhushan, Thomas Becker, Roland Beckmann
Pages 393-404
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- Daniel Boehringer, Basil Greber, Nenad Ban
Pages 405-418
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Evolution
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Front Matter
Pages 419-419
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- Sergey V. Steinberg, Konstantin Bokov
Pages 421-429
About this book
The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.
About the editors
Dr. Marina V. Rodnina
Prof. Dr. Wolfgang Wintermeyer
MPI for Biophysical Chemistry, Dept. of Physical Biochemistry, Goettingen, Germany
Dr. Rachel Green
Dept. of Molecular Biology and Genetics, Investigator, Howard Hughes Medical Institute,
Johns Hopkins University School of Medicine, Baltimore, MD, USA