Skip to main content
SpringerLink
Log in

Prostaglandin E1

New Aspects on Pharmacology, Metabolism and Clinical Efficacy

  • Conference proceedings
  • © 1991

Overview

Editors:
  1. Curt Diehm

    1. Med. Klinik im Rehabilitationskrankenhaus Karlsbad, Karlsbad, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Helmut Sinzinger

    1. Wilhelm-Auerswald-Atheroskleroseforschungsgruppe Wien, Wien, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Waltraud Rogatti

    1. Köln 91, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

About this book

Although prostaglandin El (PGE ) has been clinically available for a long 1 time, only in recent years has its effectiveness in peripheral arterial occlusive disease been confirmed in controlled studies. Not surprisingly, the favour­ able results achieved both in patients with critical limb ischaemia and in those with intermittent claudication has stimulated research activities into the clinical pharmacology of this prostaglandin. As a consequence of these efforts, exciting new findings have revealed that PGE has anti thrombotic , endothelium-stabilizing and leucocyte-stabi­ 1 lizing properties as well as effects on lipid metabolism, all of which, quite apart from its well-known anti-aggregating and vasodilator effects, may add to the clinical efficacy of the substance. New data have also been gathered on the metabolism of PGE most b notably the detection of 13,14-dihydro-PGE a metabolite which was b recently isolated in humans following the administration of PGE . Being 1 biologically active, the pharmacodynamic spectrum of 13,14-dihydro-PGE 1 very closely resembles that of PGE . This finding may help to explain the 1 efficacy of PGE despite its rapid metabolization when given intravenously.

Similar content being viewed by others

Keywords

Table of contents (13 papers)

  1. Front Matter

    Pages I-XI
    Download chapter PDF

  2. Cellular Sites of Action of Prostaglandins in the Cardiovascular System

    • K. Schrör
    Pages 1-5

  3. On the Metabolism and Pharmacokinetics of Prostaglandin E1 Administered by Intra-arterial or Intravenous Infusions

    • B. A. Peskar, W. H. Hesse, W. Rogatti, G. Rudofsky
    Pages 6-11

  4. Actions of PGE1, PGE0 and 15-keto-PGE1 on Vessel Tone in Vitro

    • M. Braun, L. Bruch, P. Ney, G. Torsello, K. Schrör
    Pages 12-20

  5. 13,14-dihydro-PGE1 (PGE0) but not 15-keto-PGE1 is a Potent Inhibitor of Human Platelet and Neutrophil Activation

    • P. Ney, M. Braun, C. Szymanski, K. Schrör
    Pages 21-32

  6. Comparable Inhibitory Action of PGE1 and 13,14-dihydro-PGE1 on Smooth Muscle Cell Activity and Extracellular Matrix Production

    • I. Neumann, P. Fitscha, J. O’grady, B. A. Peskar, H. Sinzinger
    Pages 33-38

  7. PGE1 and 13,14-dihydro-PGE1 Increase Low-Density Lipoprotein Receptors and Improve Arterial Wall Lipid Metabolism

    • H. Sinzinger, I. Virgolini, G. Lupattelli, M. Banyai
    Pages 39-48

  8. Effect of Intra-arterial and Intravenous Application of Prostaglandin E1 on Neutrophil Function in Peripheral Arterial Occlusive Disease

    • F.-J. Neumann, T. Weiss, J. Mollenhauer, M. Schneider, I. Ott, H.-M. Haupt et al.
    Pages 49-57

  9. A Comparison of Different Dosages of Intra-arterial and Intravenous Administered Prostaglandin E1 in Healthy Volunteers

    • G. Rudofsky, B. A. Peskar
    Pages 58-71

  10. Transcutaneous Oxygen Pressure at Different Dosages of Intravenous Prostaglandin E1 in Patients with Severe Arterial Occlusive Disease: A Double-Blind, Placebo-Controlled Study

    • A. Creutzig, L. Caspary, K. Alexander
    Pages 72-81

  11. Transcutaneous PO2 During Intra-arterial and Intravenous PGE1 Infusion in Patients with Critical Limb Ischaemia

    • T. Weiss, J. Griesshaber, W. Rogatti, O. Kistner, E. Hsu, T. Jansen et al.
    Pages 82-90

  12. Effects of Intravenous PGE1 on Blood Flow and Microcirculation: A Double-Blind, Placebo-Controlled Study in Patients with Critical Limb Ischaemia

    • P. Scheffler, D. de la Hamette, G. Leipnitz, J. Gross
    Pages 91-100

  13. Therapeutic Efficacy of Intravenous Prostaglandin E1 Versus Pentoxifylline in Patients with Intermittent Claudication

    • W. Hepp, S. von Bary, D. Corovic, C. Diehm, E. Mühe, G. Rudofsky et al.
    Pages 101-108

  14. Adjuvant Intravenous PGE1 Treatment After Profundaplasty for Limb Salvage

    • J. D. Gruss
    Pages 109-113

  15. Back Matter

    Pages 115-117
    Download chapter PDF
Back to top

Editors and Affiliations

  • Med. Klinik im Rehabilitationskrankenhaus Karlsbad, Karlsbad, Germany

    Curt Diehm

  • Wilhelm-Auerswald-Atheroskleroseforschungsgruppe Wien, Wien, Germany

    Helmut Sinzinger

  • Köln 91, Germany

    Waltraud Rogatti

Bibliographic Information

  • Book Title: Prostaglandin E1

  • Book Subtitle: New Aspects on Pharmacology, Metabolism and Clinical Efficacy

  • Editors: Curt Diehm, Helmut Sinzinger, Waltraud Rogatti

  • DOI: https://doi.org/10.1007/978-3-642-76910-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1991

  • Softcover ISBN: 978-3-540-54524-8Published: 20 January 1992

  • eBook ISBN: 978-3-642-76910-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 117

  • Topics: Pharmacology/Toxicology, Metabolic Diseases, Allergology, Immunology, Cardiology

Publish with us

Policies and ethics

Back to top

Search

Navigation