Abstract
The interactions of neuromuscular (NM) blocking agents (NMBA) with cholinesterases (ChE) have inportant pharmacologic and clinical implications. Some of the ester type NMBA, e.g., succinylcholine chloride (suxamethonium; SCh), suxethonium bromide, are hydrolyzed by human plasma butyrylcholinesterase (EC 3.1.1.8; BuChE) (Tsuji and Foldes 1953; Foldes et al. 1956). Their hydrolysis rate in most other mammalian plasmas is much lower than in human plasma (Tsuji and Foldes 1953). In vivo inhibition of plasma BuChE will increse the intensity and duration of action of hydrolyzable NMBA.
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References
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© 1986 Springer-Verlag Berlin Heidelberg
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Foldes, F.F., Deery, A. (1986). The Interaction of Neuromuscular Blocking Agents With Human Cholinesterases and Their Binding to Plasma Proteins. In: Kharkevich, D.A. (eds) New Neuromuscular Blocking Agents. Handbook of Experimental Pharmacology, vol 79. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70682-0_8
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DOI: https://doi.org/10.1007/978-3-642-70682-0_8
Publisher Name: Springer, Berlin, Heidelberg
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