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Protein-Protein Interactions

  • Book
  • © 2012

Overview

Editors:
  1. Michael D. Wendt

    1. , Global Pharmaceutical R & D, Abbott Laboratories, Abbott Park, USA

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  • In each volume an overview chapter introduces the newcomer to the topic covered
  • Series covers hot topics of frontier research summarized by reputed scientists in the field
  • Review series is topic related
  • Includes supplementary material: sn.pub/extras

Part of the book series: Topics in Medicinal Chemistry (TMC, volume 8)

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About this book

Michael D. Wendt
Protein-Protein Interactions as Drug Targets

Shaomeng Wang , Yujun Zhao , Denzil Bernard , Angelo Aguilar , Sanjeev Kumar
Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics

Kurt Deshayes , Jeremy Murray , Domagoj Vucic
The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer

John F. Kadow , David R. Langley , Nicholas A. Meanwell , Michael A. Walker , Kap-Sun Yeung , Richard Pracitto
Protein-Protein Interaction Targets to Inhibit HIV-1 Infection

Nicholas A. Meanwell , David R. Langley
Inhibitors of Protein-Protein Interactions in Paramyxovirus Fusion – a Focus on Respiratory Syncytial Virus

Andrew B. Mahon , Stephen E. Miller , Stephen T. Joy , Paramjit S. Arora
Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces

Michael D. Wendt
The Discovery of Navitoclax, a Bcl-2 Family Inhibitor

 

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-xviii
    Download chapter PDF

  2. Protein-Protein Interactions as Drug Targets

    • Michael D. Wendt
    Pages 1-55

  3. Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics

    • Shaomeng Wang, Yujun Zhao, Denzil Bernard, Angelo Aguilar, Sanjeev Kumar
    Pages 57-79

  4. The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer

    • Kurt Deshayes, Jeremy Murray, Domagoj Vucic
    Pages 81-103

  5. Protein-Protein Interaction Targets to Inhibit HIV-1 Infection

    • John F. Kadow, David R. Langley, Nicholas A. Meanwell, Richard Pracitto, Michael A. Walker, Kap-Sun Yeung
    Pages 105-165

  6. Inhibitors of Protein-Protein Interactions in Paramyxovirus Fusion: A Focus on Respiratory Syncytial Virus

    • Nicholas A. Meanwell, David R. Langley
    Pages 167-196

  7. Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces

    • Andrew B. Mahon, Stephen E. Miller, Stephen T. Joy, Paramjit S. Arora
    Pages 197-230

  8. The Discovery of Navitoclax, a Bcl-2 Family Inhibitor

    • Michael D. Wendt
    Pages 231-258

  9. Back Matter

    Pages 259-261
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Editors and Affiliations

  • , Global Pharmaceutical R & D, Abbott Laboratories, Abbott Park, USA

    Michael D. Wendt

Bibliographic Information

  • Book Title: Protein-Protein Interactions

  • Editors: Michael D. Wendt

  • Series Title: Topics in Medicinal Chemistry

  • DOI: https://doi.org/10.1007/978-3-642-28965-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2012

  • Hardcover ISBN: 978-3-642-28964-4Published: 28 June 2012

  • Softcover ISBN: 978-3-642-43955-1Published: 18 July 2014

  • eBook ISBN: 978-3-642-28965-1Published: 26 June 2012

  • Series ISSN: 1862-2461

  • Series E-ISSN: 1862-247X

  • Edition Number: 1

  • Number of Pages: XVIII, 262

  • Topics: Chemistry/Food Science, general

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