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Modern Anesthetics

  • Book
  • © 2008

Overview

Editors:
  1. Jürgen Schüttler

    1. Klinik fūr Anästhesiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

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  2. Helmut Schwilden

    1. Klinik fūr Anästhesiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 182)

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Table of contents (22 chapters)

  1. Pharmacokinetics-Pharmacodynamics Based Administration of Anesthetics

    1. Target Controlled Anaesthetic Drug Dosing

      • H. Schwilden, J. Schüttler
      Pages 425-450

    2. Advanced Technologies and Devices for Inhalational Anesthetic Drug Dosing

      • J. -U. Meyer, G. Kullik, N. Wruck, K. Kück, J. Manigel
      Pages 451-470

    3. Hypnotic and Opioid Anesthetic Drug Interactions on the CNS, Focus on Response Surface Modeling

      • T. W. Bouillon
      Pages 471-487

  2. Back Matter

    Pages 489-498
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Keywords

About this book

Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. “The very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.

Editors and Affiliations

  • Klinik fūr Anästhesiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

    Jürgen Schüttler, Helmut Schwilden

Bibliographic Information

  • Book Title: Modern Anesthetics

  • Editors: Jürgen Schüttler, Helmut Schwilden

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-540-74806-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2008

  • Hardcover ISBN: 978-3-540-72813-9Published: 18 December 2007

  • Softcover ISBN: 978-3-642-09192-6Published: 30 November 2010

  • eBook ISBN: 978-3-540-74806-9Published: 08 January 2008

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XVI, 498

  • Number of Illustrations: 107 b/w illustrations, 5 illustrations in colour

  • Topics: Pharmacology/Toxicology, Anesthesiology, Emergency Medicine

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