Overview
- Summarizes the latest studies on intracellular events during filovirus infection
- Focuses on mechanisms of viral entry and receptor binding, assembly of the viral particles inside the cell, and the use of reverse genetic systems
- Explains recent advances in our understnding of filovirus disease, pathology in the NHP model, and the development of new small animal models to study filovirus infectionn
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 411)
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Table of contents (16 chapters)
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Tools and Taxonomy
Keywords
About this book
For 50 years, these viruses have spilled over sporadically and without warning from their wildlife reservoirs, often causing major outbreaks and high fatalities. The consequences can be devastating, with a clear potential for global reach, as demonstrated by the 2013 West African outbreak of Ebola virus, which led to over 28,000 reported cases across three continents and more than 11,000 deaths. Given the international threat posed by these viruses, the pace and scope of basic research have also greatly intensified, ranging from studies of virus emergence, epidemiology, antiviral countermeasures and human disease to detailed mechanistic studies of virus entry, replication, virion assembly and protein structure.
Written by internationally respected experts, this book will appeal to a wide audience and be a valuable resource for basic researchers, clinicians and advanced students alike.
Editors and Affiliations
About the editors
Boston, MA, USA
e-mail: muehlber@bu.edu
Lisa L. Hensley
National Institutes of Health
NIAID
Frederick, MD, USA
e-mail: Lisa.Hensley@nih.gov
Jonathan S. Towner
Centers for Disease Control & Prevention
Atlanta, GA, USA
e-mail: jit8@cdc.gov
Bibliographic Information
Book Title: Marburg- and Ebolaviruses
Book Subtitle: From Ecosystems to Molecules
Editors: Elke Mühlberger, Lisa L. Hensley, Jonathan S. Towner
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-319-68948-7
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG (outside the USA) 2017
Hardcover ISBN: 978-3-319-68946-3Published: 30 January 2018
Softcover ISBN: 978-3-319-88689-3Published: 06 June 2019
eBook ISBN: 978-3-319-68948-7Published: 23 December 2017
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: X, 460
Topics: Virology, Infectious Diseases, Epidemiology