Overview
- Editors:
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W. Richard Chegwidden
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Lake Erie College of Osteopathic Medicine, Erie, USA
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Nicholas D. Carter
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Medical Genetics Unit, St George’s Hospital Medical School, London, UK
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Yvonne H. Edwards
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MRC Human Biochemical Genetics Unit, Wolfson House, University College London, London, UK
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Table of contents (31 chapters)
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Physiology
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- Petra Wetzel, Gerolf Gros
Pages 375-399
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Clinically Related Studies
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Front Matter
Pages 401-401
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- Umar F. Mansoor, Xiu-Rong Zhang, G. Michael Blackburn
Pages 437-459
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- Wendy B. Cammer, Luc P. Brion
Pages 475-489
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- Teuvo A. Hentunen, Pirkko L. Härkönen, H. Kalervo Väänänen
Pages 491-497
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Plant, Algal and Bacterial Carbonic Anhydrases
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Front Matter
Pages 499-499
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- Hideya Fukuzawa, Mikio Tsuzuki, Shigetoh Miyachi
Pages 535-546
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- Evguenii I. Kozliak, Michel B. Guilloton, James A. Fuchs, Paul M. Anderson
Pages 547-565
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Postscriptum
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Front Matter
Pages 567-567
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Back Matter
Pages 611-619
About this book
Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...
Editors and Affiliations
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Lake Erie College of Osteopathic Medicine, Erie, USA
W. Richard Chegwidden
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Medical Genetics Unit, St George’s Hospital Medical School, London, UK
Nicholas D. Carter
-
MRC Human Biochemical Genetics Unit, Wolfson House, University College London, London, UK
Yvonne H. Edwards