Overview
- Comprehensive review of manufacturing aspects for biopharmaceuticals, including cell and gene therapy
- Brings together the knowledge and experience of leading international experts from academia and industry
- Provides broad understanding of related problems and solutions for students, scientists, and people in industry
Part of the book series: Cell Engineering (CEEN, volume 11)
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Table of contents (15 chapters)
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Front Matter
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Manufacturing of Recombinant Therapeutic Proteins
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Front Matter
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Manufacturing Aspects of Cell and Gene Therapy
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Front Matter
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Back Matter
Keywords
About this book
This volume “Cell Engineerring 11 - Biopharmaceutical Manufacturing: Progress, Trends and Challenges” is a source of the latest innovative research and technical development in biomanufacturing systems. It is organised into 2 parts: 1) Manufacturing of recombinant therapeutic proteins (e.g. therapeutic antibodies, biosimilars/biogenerics) and 2) Manufacturing aspects of cell and gene therapy. Each with selected chapters on the following topics for both up- and downstream, such as: Advanced process strategies, especially continuous manufacturing, Advanced culture techniques, especially single-use systems, Process transfer, scale-up/scale-down models, Processing advances/Manufacturing productivity/efficiency, Model-assisted process understanding and development/Digital Twins, Process controls and analytics, Quality control, Quality by design, Facility design and full-scale commercial systems, manufacturing technology innovation.
The book comprises contributions of experts from academia and industry active in the field of cell culture development for the production of recombinant proteins, cell therapy and gene therapy, with consideration of Digital Twin´s and facility design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. Inevitably, some omissions will occur in the test, but the authors have sought to avoid duplications by extensive cross-referencing to chapters in other volumes of this series and elsewhere. We hope the volume provides a useful compendium of techniques for scientists in industrial and research laboratories active in this field.
Editors and Affiliations
About the editor
Bibliographic Information
Book Title: Biopharmaceutical Manufacturing
Book Subtitle: Progress, Trends and Challenges
Editors: Ralf Pörtner
Series Title: Cell Engineering
DOI: https://doi.org/10.1007/978-3-031-45669-5
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
Hardcover ISBN: 978-3-031-45668-8Published: 11 January 2024
Softcover ISBN: 978-3-031-45671-8Due: 11 February 2024
eBook ISBN: 978-3-031-45669-5Published: 10 January 2024
Series ISSN: 1389-6946
Series E-ISSN: 2542-9515
Edition Number: 1
Number of Pages: IX, 495
Number of Illustrations: 1 b/w illustrations
Topics: Cell Biology, Biomedical Engineering and Bioengineering, Biotechnology, Biochemical Engineering, Pharmaceutical Sciences/Technology, Chemistry/Food Science, general