Overview
- Gives a detailed introduction into the biology of the three PI3K classes
- Discusses the role of AKT and PI3K isoforms in immune cells and immune-mediated diseases
- Highlight the latest advances in the development of isoform-specific inhibitors
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 436)
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Table of contents (19 chapters)
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Front Matter
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Introduction to PI3K
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Front Matter
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PI3K and AKT Isoforms in Immune Cells
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Front Matter
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PI3K and AKT Isoforms in Immune-Mediated Diseases
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Front Matter
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PI3K Isoform Inhibitors in the Clinic
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Front Matter
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Keywords
About this book
This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease.
PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body’s own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases.
This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.
Editors and Affiliations
About the editor
Margarita Dominguez-Villar is a Senior Lecturer in Immunology at Imperial College London. Her research interests focus on the understanding of the mechanisms that regulate T cell responses and regulatory T cell function in health and disease, with a particular focus on autoimmunity and infectious diseases and the role of the PI3K/AKT pathway in controlling these processes.
Bibliographic Information
Book Title: PI3K and AKT Isoforms in Immunity
Book Subtitle: Mechanisms and Therapeutic Opportunities
Editors: Margarita Dominguez-Villar
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-031-06566-8
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
Hardcover ISBN: 978-3-031-06565-1Published: 16 October 2022
Softcover ISBN: 978-3-031-06568-2Published: 17 October 2023
eBook ISBN: 978-3-031-06566-8Published: 15 October 2022
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: VII, 466
Number of Illustrations: 5 b/w illustrations, 37 illustrations in colour
Topics: Immunology, Cell Biology