Overview
- Editors:
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Lakshmi A. Devi
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Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York
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Table of contents (18 chapters)
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GPCRs: Structure and Function
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- Dominique Massotte, Brigitte L. Kieffer
Pages 3-31
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- Peng Huang, Lee-Yuan Liu-Chen
Pages 33-70
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- Ulla E. Petäjä-Repo, Michel Bouvier
Pages 71-93
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- James N. Hislop, Mark von Zastrow
Pages 95-105
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GPCR Activity and Its Regulators
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Front Matter
Pages 107-107
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- Tracy Nguyen Hwangpo, Ravi Iyengar
Pages 109-134
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- Ryan W. Richman, MarÃa A. Diversé-Pierluissi
Pages 135-148
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- Lan Ma, Jingxia Gao, Xiaoqing Chen
Pages 149-158
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- Hongyan Wang, Catherine B. Willmore, Jia Bei Wang
Pages 199-213
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GPCR Dimerization/Oligomerization
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Front Matter
Pages 215-215
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- Karen M. Kroeger, Kevin D. G. Pfleger, Karin A. Eidne
Pages 217-241
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- Marta Filizola, Wen Guo, Jonathan A. Javitch, Harel Weinstein
Pages 243-265
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- Graeme Milligan, Juan J. Carrillo, Geraldine Pascal
Pages 267-285
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- Michael M. C. Kong, Christopher H. So, Brian F. O’Dowd, Susan R. George
Pages 287-307
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- Selena E. Bartlett, Jennifer L. Whistler
Pages 309-322
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- Noura S. Abul-Husn, Achla Gupta, Lakshmi A. Devi, Ivone Gomes
Pages 323-346
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Recent Developments in Drug Discovery
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Front Matter
Pages 347-347
About this book
A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.
Reviews
"...provides an excellent resource to introduce the reader to many of the diverse areas and questions that drive research in the GCPR field." -TRENDS in Endocrinology and Metablosim
Editors and Affiliations
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Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York
Lakshmi A. Devi