Overview
- Addresses toxicity testing, in vitro, in a variety of different human system simulations
- Features difficult areas of toxicology such as carcinogenicity and nanotoxicology
- Benefits students and experts in the field of chemical safety assessment as well as a wider scientific audience
- Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Pharmacology and Toxicology (MIPT)
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Table of contents (25 protocols)
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The Use of Stem Cells
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Front Matter
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Challenges and Considerations
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Front Matter
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Back Matter
Keywords
About this book
In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches.
Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists and regulators working in the field of chemical safety assessment but also to a wider scientific audience.
Editors and Affiliations
Bibliographic Information
Book Title: In Vitro Toxicology Systems
Editors: Anna Bal-Price, Paul Jennings
Series Title: Methods in Pharmacology and Toxicology
DOI: https://doi.org/10.1007/978-1-4939-0521-8
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media New York 2014
Hardcover ISBN: 978-1-4939-0520-1Published: 01 May 2014
Softcover ISBN: 978-1-4939-5480-3Published: 03 September 2016
eBook ISBN: 978-1-4939-0521-8Published: 30 April 2014
Series ISSN: 1557-2153
Series E-ISSN: 1940-6053
Edition Number: 1
Number of Pages: XXI, 583
Number of Illustrations: 10 b/w illustrations, 54 illustrations in colour