Overview
- Editors:
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Claes Göran Östenson
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Karolinska Hospital, Stockholm, Sweden
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Suad Efendić
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Karolinska Hospital, Stockholm, Sweden
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Mladen Vranic
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University of Toronto, Toronto, Canada
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Table of contents (24 chapters)
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Regulation of Insulin Secretion
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- Claes-Göran Östenson, Akhtar Khan, Suad Efendic
Pages 1-11
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- Per-Olof Berggren, Per Arkhammar, Md Shahidul Islam, Lisa Juntti-Berggren, Akhtar Khan, Henrik Kindmark et al.
Pages 25-45
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- Stephen J. H. Ashcroft, Ichiro Niki, Sue Kenna, Ling Weng, Jackie Skeer, Barbara Coles et al.
Pages 47-61
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Insulin,Insulin Receptors and Glucose Transporters
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- Harinder S. Hundal, Amira Klip
Pages 63-78
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- Holger Luthman, Ingrid Delin, Anna Glaser, Rolf Luft, Svante Norgren, Anna Wedell
Pages 101-111
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- Shlomo Sasson, Yaqoub Ashhab, Danielle Melloul, Erol Cerasi
Pages 113-127
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Insulin Action in NIDDM
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- Z. Q. Shi, A. Giacca, S. J. Fisher, M. Lekas, D. Bilinski, M. Van Delangeryt et al.
Pages 151-168
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- Ulf Smith, Stig Attvall, Jan Eriksson, Jesper Fowelin, Peter Lönnroth, Christian Wesslau
Pages 169-180
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- Richard N. Bergman, David C. Bradley, Marilyn Ader
Pages 181-198
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Gluconeogenesis
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- Alan D. Cherrington, Ralph W. Stevenson, Kurt E. Steiner, Cynthia C. Connolly, Masahiko Wada, Richard E. Goldstein
Pages 199-208
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- Iva K. Martin, John Wahren
Pages 221-233
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- Jerry Radziuk, Susan Pye, Zi Zhang
Pages 235-252
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- John E. Gerich, Nurjahan Nurjhan
Pages 253-258
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About this book
The pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) has attracted the interest of our group during the last three decades. As early as 1969, a Nobel Symposium dealing with this topic was organized in Stockholm. This was followed in 1987 by a Nobel Conference devoted to the same subject. The main purpose of these meetings was to bring together the most distinguished scientists from all over the world and present theories on molecular and genetic mechanisms responsible for the development of glucose intolerance in NIDDM. This idea was followed also in the present symposium, "New Concepts in the Pathogenesis of NIDDM," organized with diabetologists from Toronto in Canada. Our purpose is to biannually organize international meetings covering important aspects of dia betes research, hoping that this type of interaction may result in new concepts and treat ment alternatives. For us, participating in this symposium in September 1992, the meeting in Stockholm was very stimulating and innovative. It is a special pleasure that almost all invited lecturers submitted manuscripts. Thus, the publication of the proceedings of the symposium makes it possible for all interested in diabetes research to share new ideas and findings presented at the meeting. Claes-G6ran Ostenson Suad Efendic Mladen V ranic v CONTENTS REGULATION OF INSULIN SECRETION Impaired Glucose-Induced Insulin Secretion: Studies in Animal Models with Spontaneous NIDDM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . C. -G. Ostenson, A. Khan, and S. Efendic Perturbation ofIslet Metabolism and Insulin Release in NIDDM. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 WJ.Malaisse 2 Regulation of Cytoplasmic Free Ca+ in Insulin-Secreting Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .