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The ß-Cell Sulfonylurea Receptor

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 334)

Abstract

It is now 50 years since the accidental observations which indicated that a sulfonamide, p-amino-benzene-sulfamido-isopropyl-thiodiazole (2254 RP), could induce hypoglycaemia (Janbon et al., 1942). This response was shown to be due to stimulation of insulin secretion and led to the use of this class of sulfonamides (called sulfonylureas) to treat diabetes (Loubatières, 1955; Bertram et al., 1955; Franke et al., 1955). Loubatières (1944) also found that a related sulfonamide, 3-methy1-7-chloro-1,2,4-benzothiadiazine-1,1-dioxide (diazoxide) elicited hyperglycaemia, via inhibition of insulin secretion.

Keywords

Insulin Secretion Scatchard Plot Rose Bengal Sulfonylurea Receptor Fluorescein Derivative 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  1. 1.Nuffield Department of Clinical BiochemistryJohn Radcliffe HospitalHeadington, OxfordUK
  2. 2.University Laboratory of PhysiologyOxfordUK

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