Overview
- Focuses on key aspects of TRPs in health and disease
- Provides a detailed discussion of repeat sequences as mutable sites providing genetic variability upon which natural selection can act
- Provides insights into how expanded polyalanine in specific proteins leads to developmental abnormalities and neurocognitive dysfunction
Part of the book series: Advances in Experimental Medicine and Biology (AEMB)
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Table of contents (12 chapters)
Editors and Affiliations
About the editor
ANTHO NY J. HANNAN is Head of the Neural Plasticity Laboratory, Florey Neuroscience Institutes and Associate Professor at the University of Melbourne, Parkville, Australia. Following undergraduate and PhD degrees at the University of Sydney, Anthony received postdoctoral neuroscience training at the University of Oxford, supported by a Nuffield Medical Fellowship. He currently holds an Australian Research Council (ARC) Future Fellowship (FT3) and an Honorary Senior Research Fellowship from the National Health and Medical Research Council (NHMRC). Main research interests include pathogenic mechanisms mediating Huntington’s disease and related tandem repeat expansion disorders, as well as other cognitive and psychiatric illnesses. In his laboratory, experimental models of gene‑environment interactions are used to explore experience‑dependent plasticity in the healthy and diseased brain.
Bibliographic Information
Book Title: Tandem Repeat Polymorphisms
Book Subtitle: Genetic Plasticity, Neural Diversity and Disease
Editors: Anthony J. Hannan
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-1-4614-5434-2
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2012
Hardcover ISBN: 978-1-4614-5433-5Published: 13 November 2012
Softcover ISBN: 978-1-4939-5448-3Published: 23 August 2016
eBook ISBN: 978-1-4614-5434-2Published: 30 July 2013
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XIX, 208
Topics: Biomedicine general, Neurosciences, Gene Function