Molecular Pathways to Polyglutamine Aggregation

Part of the Advances in Experimental Medicine and Biology book series (AEMB)


Over 100 human cellular proteins contain a repetitive polyglutamine tract, however, only nine of these proteins are associated with disease. In these proteins, the expanded polyQ tract perturbs the native conformation, resulting in an ordered aggregation process that leads to the formation of amyloid-like fibrils. The misfolding pathway involves the formation of prefibrillar oligomeric structures, which are proposed to be involved in cellular toxicity. Non-polyQ host protein regions modulate the misfolding pathway, suggesting an importance of protein context in aggregation. This chapter describes the current research regarding polyQ misfolding, with emphasis on the species populated during aggregation, suggesting an important role of protein context in modulating the aggregation pathway.


Saturation Transfer Difference polyQ Protein Tandem Repeat Polymorphism polyQ Tract polyQ Aggregation 
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Copyright information

© Landes Bioscience and Springer Science+Business Media 2012

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyMonash UniversityClaytonAustralia

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