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Mass Spectrometry in the Biological Sciences

  • Book
  • © 1996

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Editors:
  1. A. L. Burlingame

    1. University of California, San Francisco, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Steven A. Carr

    1. SmithKline Beecham Pharmaceuticals, King of Prussia, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xii
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  2. Mass Spectrometry in the Health and Life Sciences

    • Judith L. Vaitukaitis, Maureen Mylander
    Pages 1-4

  3. Designing Time-of-Flight Mass Spectrometers for the Future: Multichannel Recording of Peptide Amino Acid Sequences

    • Robert J. Cotter, Timothy J. Cornish, Marcela Cordero
    Pages 5-23

  4. The Role of Fourier Transform Ion Cyclotron Resonance Mass Spectrometry in Biological Research — New Developments and Applications

    • R. D. Smith, J. E. Bruce, Q. Wu, X. Cheng, S. A. Hofstadler, G. A. Anderson et al.
    Pages 25-68

  5. Electrospray Ionization Mass Spectrometry: The Observation of Covalent, Ionic and Non-Covalent Interactions.

    • Robin T. Aplin, Carol V. Robinson
    Pages 69-84

  6. Using Deuterium Exchange and Mass Spectrometry to Study Protein Structure

    • Robert J. Anderegg
    Pages 85-104

  7. MALDI-TOF Mass Spectrometry in the Protein Biochemistry Lab: From Characterization of Cell Cycle Regulators to the Quest for Novel Antibiotics

    • Paul Tempst, Hediye Erdjument-Bromage, Peter Casteels, Scott Geromanos, Mary Lui, Michael Powell et al.
    Pages 105-133

  8. Chemistry, Mass Spectrometry and Peptide-Mass Databases: Evolution of Methods for the Rapid Identification and Mapping of Cellular Proteins

    • D. J. C. Pappin, D. Rahman, H. F. Hansen, M. Bartlet-Jones, W. Jeffery, A. J. Bleasby
    Pages 135-150

  9. Identification of Electroblotted Proteins by Peptide Mass Searching of a Sequence Database

    • John T. Stults, William J. Henzel, Susan C. Wong, Colin Watanabe
    Pages 151-170

  10. Mass Spectrometric Identification of Proteins Isolated By Two-Dimensional Gel Electrophoresis

    • Steven C. Hall, Karl R. Clauser, Lori E. Andrews, Fred C. Walls, Diana M. Smith, Huu M. Tran et al.
    Pages 171-202

  11. Infrared-Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (IR-MALDI-MS) of Proteins Electroblotted onto Polymer Membranes After SDS-PAGE Separation

    • Kerstin Strupat, Michael Karas, Franz Hillenkamp, Christoph Eckerskorn
    Pages 203-216

  12. Picoliter Vials: A New Sample Handling Technique for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

    • S. Jespersen, W. M. A. Niessen, U. R. Tjaden, J. van der Greef, E. Litborn, U. Lindberg et al.
    Pages 217-226

  13. Direct Neuropeptide Profiling of Single Neurons and Target Tissue by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry

    • C. R. Jiménez, K. W. Li, A. B. Smit, J. van Minnen, C. Janse, W. P. M. Geraerts et al.
    Pages 227-243

  14. Approaches to the Practical Use of MS/MS in a Protein Sequencing Facility

    • M. Wilm, T. Houthaeve, G. Talbo, R. Kellner, P. Mortensen, M. Mann
    Pages 245-265

  15. Capillary Liquid Chromatography/Electrospray Mass Spectrometry with a Magnetic Sector Instrument for Accurate Mass Measurement of Peptide and Protein Mixtures

    • Hiroshi Murata, Toshifumi Takao, Yasutsugu Shimonishi
    Pages 267-280

  16. Mass Spectrometric Methods for Peptide Sequencing: Applications to Immunology and Protein Acylation

    • Pamela H. Gulden, Murray Hackett, Theresa A. Addona, Lin Guo, Carthene B. Walker, Nicholas E. Sherman et al.
    Pages 281-305

  17. A Multifaceted Strategy for the Characterization of Recombinant gD-2, a Potential Herpes Vaccine

    • Mark E. Hemling, Mary A. Mentzer, Steven A. Carr, Carine Capiau
    Pages 307-331

  18. Identifying Unexpected Protein Modifications

    • Reed J. Harris, Michael S. Molony, May Y. Kwong, Victor T. Ling
    Pages 333-350

  19. Mass Spectrometry in Carbohydrate Recognition Studies

    • A. M. Lawson, W. Chai, C.-T. Yuen, T. Feizi
    Pages 351-364

  20. Mass Spectrometric and Tandem Mass Spectrometric Approaches to the Analysis of Glycoconjugates

    • Catherine E. Costello, Hélène Perreault, Lambert C. Ngoka
    Pages 365-384
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Keywords

About this book

Leading practitioners describe in detail advanced methods of mass spectrometry used in structural characterization of biomacromolecules of both natural and recombinant origin. They demonstrate by example how these methodologies can solve a wide array of real-world problems in protein biochemistry, immunology, and glycobiology, as well as for human bacterial pathogens, lipids, and nucleic acids. The book offers a unique opportunity to learn these techniques that are revolutionizing the field. Its authoritative assessment in the context of how to solve important and challenging problems in bioscience and medicine ensures a competitive advantage for today's researchers.

Reviews

The articles are uniformly well written...In summary, the book best serves the community interested in the characterization of proteins by mass spectrometer methods, but it contains valuable insights for analysis of other biomolecules as well.- Quarterly Review of Biology

Editors and Affiliations

  • University of California, San Francisco, USA

    A. L. Burlingame

  • SmithKline Beecham Pharmaceuticals, King of Prussia, USA

    Steven A. Carr

Bibliographic Information

  • Book Title: Mass Spectrometry in the Biological Sciences

  • Editors: A. L. Burlingame, Steven A. Carr

  • DOI: https://doi.org/10.1007/978-1-4612-0229-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1996

  • Hardcover ISBN: 978-0-89603-340-5Published: 05 January 1996

  • Softcover ISBN: 978-1-4612-6671-6Published: 09 October 2012

  • eBook ISBN: 978-1-4612-0229-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 570

  • Topics: Mass Spectrometry, Analytical Chemistry

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