Targeted Drug Strategies for Cancer and Inflammation

  • Ann L. Jackman
  • Christopher P. Leamon

Table of contents

  1. Front Matter
    Pages i-xi
  2. Barton A. Kamen
    Pages 35-47
  3. Mesfin Gonit, Marcela D’Alincourt Salazar, Juan Zhang, Hala Elnakat, Suneethi Sivakumaran, Manohar Ratnam
    Pages 49-63
  4. Cristina Müller, Roger Schibli
    Pages 65-92
  5. Ann L. Jackman, Gerrit Jansen, Matthew Ng
    Pages 93-117
  6. Joseph A. Reddy, Christopher P. Leamon
    Pages 135-150
  7. Alberto Gabizon, Hilary Shmeeda, Hemda Baabur-Cohen, Ronit Satchi-Fainaro
    Pages 217-247
  8. Alberto Gabizon, Hilary Shmeeda, Hemda Baabur-Cohen, Ronit Satchi-Fainaro
    Pages E1-E1
  9. Back Matter
    Pages 249-254

About this book

Introduction

The discoveries highlighted in this book parallel the emergence of innovative “molecular targeted” small molecules and monoclonal antibodies, i.e. agents that target proteins within highly activated signal transduction pathways that control proliferation.  Many of the tumor-targeted strategies described within cross the boundaries between what’s considered to be “molecular targeted” versus conventional systemic therapy.  However, the main theme of this volume is the folate receptor (FR), with much of the content focused on its basic biology and regulation as well as its exploitation for targeted therapy and diagnostic imaging.

Keywords

De Novo Purine Nucleotide Biosynthesis RFC-SLC19A1 Thymidylate Synthase Inhibitors folate receptors monoclonal antibodies

Editors and affiliations

  • Ann L. Jackman
    • 1
  • Christopher P. Leamon
    • 2
  1. 1.Section of MedicineInstitute of Cancer ResearchSuttonUnited Kingdom
  2. 2.Endocyte Inc.West LafayetteUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-8417-3
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-8416-6
  • Online ISBN 978-1-4419-8417-3
  • About this book