Clinical and Experimental Pathology of Lung Cancer

  • J. G. McVie
  • W. Bakker
  • Sj. Sc. Wagenaar
  • D. Carney

Part of the Developments in Oncology book series (DION, volume 39)

Table of contents

  1. Front Matter
    Pages I-X
  2. Heine H. Hansen
    Pages 1-6
  3. William W. Johnston
    Pages 65-74
  4. J. D. Elema, L. De Leij, P. Postmus, S. Poppema, T. H. The
    Pages 91-103
  5. L. L. Vindeløv, S. Aa. Engelholm, M. Spang-Thomsen
    Pages 105-112
  6. C. Gropp
    Pages 123-130
  7. A. J. Van Der Eb
    Pages 131-137
  8. R. K. Oldham, M. H. West
    Pages 149-163
  9. L. Austin Doyle, Joseph Aisner
    Pages 165-185
  10. Back Matter
    Pages 187-188

About this book


J. G. MCVIE The impact of therapy on one subset of lung cancer, the "small cell" type has been significant and lasting. The reality of cure for even a fraction of patients with this disease has caused reverberations in the pathology lab where the responsibili. '~y and challenge of diagnosis of this vital sub group lies. No less dramatic has been the discovery that the cell types of lung cancer have recognisable growth characteristics in serum free culture, they are recognisable by patterns of markers and some produce growth factors which autoregulate their eventual fate. Many of the discoveries from the biological studies have impacted on the pathologist in the form of disturbing evidence for a single stem cell origin for all the cell types of lung cancer and in the shape of new facilitation in diagnosis by appli­ cation of immunoperoxidase techniques. Monoclonal antibodies raised against oncogene products, growth factor receptor sites, "bystander" cell membrane proteins can all be applied to cytology specimens and frozen or paraffin fixed tissue sections to aid diagnosis and some can be used in sequential serum assay to monitor therapy and predict prognosis. Adding to these extraordinary tools, the sophistication of electron micro­ scopy and immuno-electrcn microscopy, new techniques for preparation of tissue and novel methods for studying vital cells in "kinesis", you sense the flavour of the future of lung cancer which is captured in this book.


DNA carcinoma cell classification hormones imaging liver metastasis pathology

Editors and affiliations

  • J. G. McVie
    • 1
  • W. Bakker
    • 2
  • Sj. Sc. Wagenaar
    • 3
  • D. Carney
    • 4
  1. 1.Netherlands Cancer InstituteAmsterdamThe Netherlands
  2. 2.Department of PneumologyUniversity Hospital LeidenThe Netherlands
  3. 3.Department of Pathological AnatomySint Antonius HospitalNieuwegeinThe Netherlands
  4. 4.Mater Miserecordia HospitalDublinIreland

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1986
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-8731-5
  • Online ISBN 978-94-009-5036-8
  • Buy this book on publisher's site