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The Search for Anti-Inflammatory Drugs

Case Histories from Concept to Clinic

  • Book
  • © 1995

Overview

Editors:
  1. Vincent J. Merluzzi

    1. Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Julian Adams

    1. MyoGenics, Inc., Cambridge, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-x
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  2. The Discovery of Drugs to Treat Arthritis: A Historical View

    • Ivan G. Otterness
    Pages 1-26

  3. The History of the Discovery and Development of Cyclosporine (Sandimmune®)

    • J. F. Borel, Z. L. Kis, T. Beveridge
    Pages 27-63

  4. Discovery and Development of FK506 (Tacrolimus), A Potent Immunosuppressant of Microbial Origin

    • Michihisa Nishiyama, Shizue Izumi, Masakuni Okuhara
    Pages 65-104

  5. Discovery of Sulindac, a Reversible Prodrug, as a Second-Generation Indomethacin

    • Tsung Ying Shen
    Pages 105-128

  6. The Discovery of Zileuton (Leutrol®)

    • Dee W. Brooks, George W. Carter
    Pages 129-160

  7. Discovery of Accolate™ (ICI 204,219), a Peptide Leukotriene Antagonist for Asthma

    • Frederick J. Brown
    Pages 161-189

  8. Discovery of ZD2138, a Potent, Selective, Well-Tolerated, Nonredox Inhibitor of the Enzyme 5-Lipoxygenase

    • G. C. Crawley, S. J. Foster, R. M. McMillan, E. R. H. Walker
    Pages 191-231

  9. Development of MK 0591: An Orally Active Leukotriene Biosynthesis Inhibitor with a Novel Mechanism of Action

    • Petpiboon Prasit, Philip J. Vickers
    Pages 233-251

  10. Discovery of BIRM 270: A New Class of Leukotriene Biosynthesis Inhibitors

    • Peter R. Farina, Carol Ann Homon, Edward S. Lazer, Thomas P. Parks
    Pages 253-274

  11. Discovery and Development of the Immunomodulatory Azaspiranes

    • Alison M. Badger
    Pages 275-301

  12. Back Matter

    Pages 303-304
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Keywords

About this book

Perspectives on Anti-Inflammatory Drugs Inflammation is a very complicated process of interrelated events and cas­ cades that does not allow for an easily defined, focused attack for drug discovery. It is evident from years of research and development that certain classes of compounds (e.g., NSAIDs, steroids, and so on) have had a meas­ ure of success in alleviating pain and even dampening cellularlhormonal mechanisms involved in the process. Clear, mechanism-related therapies (e.g., for arthritis) and targeted drugs (e.g., for transplantation) have not been available in the past and, in reality, research in inflammation has re­ lied on more phenomenological approaches for resolving symptoms or on blatant cytoreductive approaches in cases like organ transplantation. In the last decade, approaches that have revealed novel cellular pathways in which intervention is possible for lymphocyte regulation (for example, cyclosporine and FK506) and small molecular weight mediators (e.g., leu­ kotriene inhibitors) are now either standard therapy or will be in a short time. These latter approaches have been the result of research from the 1970s up to the present.

Editors and Affiliations

  • Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, USA

    Vincent J. Merluzzi

  • MyoGenics, Inc., Cambridge, USA

    Julian Adams

Bibliographic Information

  • Book Title: The Search for Anti-Inflammatory Drugs

  • Book Subtitle: Case Histories from Concept to Clinic

  • Editors: Vincent J. Merluzzi, Julian Adams

  • DOI: https://doi.org/10.1007/978-1-4615-9846-6

  • Publisher: Birkhäuser Boston, MA

  • eBook Packages: Springer Book Archive

  • Copyright Information: Birkhäuser Boston 1995

  • Softcover ISBN: 978-1-4615-9848-0Published: 05 February 2012

  • eBook ISBN: 978-1-4615-9846-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 304

  • Topics: Medicine/Public Health, general, Chemistry/Food Science, general

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