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Discovery of ZD2138, a Potent, Selective, Well-Tolerated, Nonredox Inhibitor of the Enzyme 5-Lipoxygenase

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The Search for Anti-Inflammatory Drugs

Abstract

Leukotrienes are a family of biologically active lipids formed by oxidative metabolism of arachidonic acid. Leukotriene B4 (LTB4) is a potent chemotactic agent and induces inflammatory reactions in animals and in humans. The peptido-leukotrienes, leukotrienes C4, D4, and E4, have powerful spasmogenic actions in vascular and bronchial tissue and are the major mediators responsible for slow reacting substance of anaphylaxis (SRS-A) activity.

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Authors
  1. G. C. Crawley
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  2. S. J. Foster
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  3. R. M. McMillan
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  4. E. R. H. Walker
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Editor information

Editors and Affiliations

  1. Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT, 06877, USA

    Vincent J. Merluzzi

  2. MyoGenics, Inc., 1 Kendall Square, Bldg 200, Cambridge, MA, 02139, USA

    Julian Adams

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© 1995 Birkhäuser Boston

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Crawley, G.C., Foster, S.J., McMillan, R.M., Walker, E.R.H. (1995). Discovery of ZD2138, a Potent, Selective, Well-Tolerated, Nonredox Inhibitor of the Enzyme 5-Lipoxygenase. In: Merluzzi, V.J., Adams, J. (eds) The Search for Anti-Inflammatory Drugs. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-9846-6_7

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  • DOI: https://doi.org/10.1007/978-1-4615-9846-6_7

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4615-9848-0

  • Online ISBN: 978-1-4615-9846-6

  • eBook Packages: Springer Book Archive

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