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Terpenes from Forests and Human Health
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  • Review Article
  • Open Access
  • Published: 01 April 2017

Terpenes from Forests and Human Health

  • Kyoung Sang Cho1,2,
  • Young-ran Lim1,
  • Kyungho Lee1,2,
  • Jaeseok Lee1,2,
  • Jang Ho Lee1 &
  • …
  • Im-Soon Lee1,2 

Toxicological Research volume 33, pages 97–106 (2017)Cite this article

  • 767 Accesses

  • 123 Citations

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Abstract

Forest bathing has beneficial effects on human health via showering of forest aerosols as well as physical relaxation. Terpenes that consist of multiple isoprene units are the largest class of organic compounds produced by various plants, and one of the major components of forest aerosols. Traditionally, terpene-containing plant oil has been used to treat various diseases without knowing the exact functions or the mechanisms of action of the individual bioactive compounds. This review categorizes various terpenes easily obtained from forests according to their anti-inflammatory, anti-tumorigenic, or neuroprotective activities. Moreover, potential action mechanisms of the individual terpenes and their effects on such processes, which are described in various in vivo and in vitro systems, are discussed. In conclusion, the studies that show the biological effectiveness of terpenes support the benefits of forest bathing and propose a potential use of terpenes as chemotherapeutic agents for treating various human diseases.

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Abbreviations

BCP:

ß-caryophyllene

GPP:

geranyl pyrophosphate

DMAPP:

dimethylallyl pyrophosphate

IPP:

isopentenyl pyrophosphate

MAPK:

mitogen-activated protein kinase

NF-ΚB:

nuclear factor kappa B

IL:

interleukin

TNF-oα:

tumor necrosis factor-oα

NO:

nitric oxide

LPS:

lipopolysaccharide

MMP:

matrix metalloproteinases

AD:

Alzheimer’s disease

PD:

Parkinson’s disease

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Authors and Affiliations

  1. Department of Biological Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Korea

    Kyoung Sang Cho, Young-ran Lim, Kyungho Lee, Jaeseok Lee, Jang Ho Lee & Im-Soon Lee

  2. Research Center for Coupled Human and Natural Systems for Ecowelfare, Konkuk University, Seoul, Korea

    Kyoung Sang Cho, Kyungho Lee, Jaeseok Lee & Im-Soon Lee

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Cho, K.S., Lim, Yr., Lee, K. et al. Terpenes from Forests and Human Health. Toxicol Res. 33, 97–106 (2017). https://doi.org/10.5487/TR.2017.33.2.097

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  • Received: 06 February 2017

  • Revised: 14 February 2017

  • Accepted: 16 February 2017

  • Published: 01 April 2017

  • Issue Date: April 2017

  • DOI: https://doi.org/10.5487/TR.2017.33.2.097

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Key words

  • Cancer
  • Forest therapy
  • Health
  • Immune function
  • Neuronal health
  • Terpene
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