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Hair Growth-Promoting Effects of Lavender Oil in C57BL/6 Mice

Toxicological Research volume 32, pages 103–108 (2016)Cite this article

Abstract

The purpose of this study was to determine the hair growth effects of lavender oil (LO) in female C57BL/6 mice. The experimental animals were divided into a normal group (N: saline), a vehicle control group (VC: jojoba oil), a positive control group (PC: 3% minoxidil), experimental group 1 (E1: 3% LO), and experimental group 2 (E2: 5% LO). Test compound solutions were topically applied to the backs of the mice (100 µL per application), once per day, 5 times a week, for 4 weeks. The changes in hair follicle number, dermal thickness, and hair follicle depth were observed in skin tissues stained with hematoxylin and eosin, and the number of mast cells was measured in the dermal and hypodermal layers stained with toluidine blue. PC, E1, and E2 groups showed a significantly increased number of hair follicles, deepened hair follicle depth, and thickened dermal layer, along with a significantly decreased number of mast cells compared to the N group. These results indicated that LO has a marked hair growth-promoting effect, as observed morphologically and histologically. There was no significant difference in the weight of the thymus among the groups. However, both absolute and relative weights of the spleen were significantly higher in the PC group than in the N, VC, E1, or E2 group at week 4. Thus, LO could be practically applied as a hair growth-promoting agent.

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Authors and Affiliations

  1. Department of Beauty Art, Changwon Moonsung University, Changwon, Korea

    Boo Hyeong Lee

  2. Department of Beauty Design, Gyongbuk Science College, Chilgok, Korea

    Jae Soon Lee

  3. Department of Public Health, Keimyung University, 1095 Dalgubeol-daero, Daegu, 42601, Korea

    Young Chul Kim

Authors
  1. Boo Hyeong Lee
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  2. Jae Soon Lee
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  3. Young Chul Kim
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Correspondence to Young Chul Kim.

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Lee, B.H., Lee, J.S. & Kim, Y.C. Hair Growth-Promoting Effects of Lavender Oil in C57BL/6 Mice. Toxicol Res. 32, 103–108 (2016). https://doi.org/10.5487/TR.2016.32.2.103

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  • DOI: https://doi.org/10.5487/TR.2016.32.2.103

Key words

  • C57BL/6 mice
  • Dermal thickness
  • Hair growth
  • Hair follicle
  • Lavender oil