Abstract
The probability of additional offspring with a beneficial reversal allele for growing to a size NC for a range of population sizes N, sequence lengths L, selective advantages s, and measuring parameters C was calculated for a haploid, asexual population in the coupled discrete-time mutation-selection model in an asymmetric sharply-peaked landscape with a positive selective advantage of the reversal allele over the optimal allele. The growing probability in the stochastic region was inversely proportional to the measuring parameter when C < 1/Ns, bent when C ≈ 1/Ns and saturated when C > 1/Ns. The crossing time and the time dependence of the increase in relative density of the reversal allele in the coupled discrete-time mutation-selection model was approximated using the Wright-Fisher two-allele model with the same selective advantage and corresponding effective mutation rate. The growth behavior of additional offspring with the reversal allele in the asymmetric sharply-peaked landscape in the coupled discrete-time mutation-selection model was controlled by the selective advantage of the reversal allele compared to the optimal allele and could be described by using the Wright-Fisher two-allele model, in spite of there being many other alleles with lower fitness, and in spite of there being two alleles, the optimal and reversal allele, separated by a low-fitness valley with a tunable depth and width.
Similar content being viewed by others
References
I. M. Rouzine, A. Rodrigo and J. M. Coffin, Microbiol. Mol. Biol. R. 65, 151 (2001).
K. Jain and J. Krug, Genetics 175, 1275 (2007).
Y. Iwasa, F. Michor and M. A. Nowak, Genetics 166, 1571 (2004).
D. B. Weissman, M. M. Desai, D. S. Fisher and M. W. Feldman, Theor. Popul. Biol. 75, 286 (2009).
S. J. Schrag, V. Perrot and B. R. Levin, Proc. R. Soc. London, Ser. B 264, 1287 (1997).
B. R. Levin, V. Perrot and N. Walker, Genetics 154, 985 (2000).
S. Maisnier-Patin, O. G. Berg, L. Liljas and D. I. Andersson, Mol. Microbiol. 46, 355 (2002).
A. M. Borman, S. Paulous and F. Clavel, J. Gen. Virol. 77, 419 (1996).
A. G. Knudson, Nat. Rev. Cancer 1, 157 (2001).
P. G. Higgs, Genet. Res. Camb. 63, 63 (1994).
S. Franz and L. Peliti, J. Phys. A: Math. Gen. 30, 4481 (1997).
R. Bürger, Genetica 102/103, 279 (1998).
B. Drossel, Adv. Phys. 50, 209 (2001).
L. Peliti, Europhys. Lett. 57, 745 (2002).
K. S. Lee and W. Gill, Int. J. Mod. Phys. C 18, 1985 (2007).
W. Gill, Physica A 388, 3124 (2009).
W. Gill, J. Korean Phys. Soc. 57, 192 (2010).
W. Gill, J. Korean Phys. Soc. 55, 709 (2009).
W. J. Ewens, Mathmatical Population Genetics I. Theoretical Introduction Interdisciplinary Applied Mathmatics, 2nd ed. (Springer, Berlin, 2004), Vol. 27.
E. Baake, J. Biol. Syst. 3, 343 (1995).
E. Baake, M. Baake and H. Wagner, Phys. Rev. Lett. 78, 559 (1997).
H. Wagner, E. Baake and T. Gerisch, J. Stat. Phys. 92, 1017 (1998).
E. Baake and W. Gabrial, Annual Reviews of Computational Physics VII, edited by D. Stauffer (World Scientific, Singapore, 2000).
J. Swetina and P. Schuster, Biophys. Chem. 16, 329 (1982).
M. Kimura, Genetics 47, 713 (1962).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gill, W. Growth behavior of additional offspring with a beneficial reversal allele in the asymmetric sharply-peaked landscape in the coupled discrete-time mutation-selection model. Journal of the Korean Physical Society 62, 172–180 (2013). https://doi.org/10.3938/jkps.62.172
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.3938/jkps.62.172