Abstract
Manganese ferrite nanoparticles were synthesized using the reverse micelle method and were coated with gold. TEM (transmission electron microscope) pictures showed that the shapes of the synthesized nanoparticles were almost spherical with an average diameter of 12 nm and a standard error of 4 nm. The bonding status of gold on the nanoparticle surfaces was checked using a Fourier transform infrared spectrometer (FTIR). The T1 and the T2 relaxation times of the hydrogen protons in aqueous solutions of the coated manganese-ferrite nanoparticles were determined using magnetic resonance imaging (MRI). The 1/T 1 and the 1/T 2 versus concentration curves for the nanoparticles showed a linear dependence. The T1 and the T2 relaxivities were found to be r 1 = 6.01 ± 0.12 and r 2 = 83.3 ± 0.55 mM−1 s −1. The ratio of r 2/r 1 was 13.9; this is larger than the ratios of r 2/r 1 for commercial T2 MRI contrast agents, indicating that the nanoparticles studied herein can serve as a T2 contrast agent with high efficacy.
Similar content being viewed by others
References
M. R. DeGuire, G. Kalonji and R. C. O’Handley, J. Am. Ceram. Soc. 73, 3002 (1990).
M. A. Willard, Y. Nakamura, E. D. Laughlin and E. M. McHenry, J. Am. Ceram. Soc. 82, 3342 (1999).
M. Ishikawa, H. Tanaka and T. Kawai, Appl. Phys. Lett. 86, 222504 (2005).
C. Rath, N. C. Mishra, S. Anand, R. P. Das, C. Upadhyay and H. C. Verma, Appl. Phys. Lett. 76, 475 (2000).
D. K. Kim, Y. Zhang, W. Voit, K. V. Rao, M. Muhammed, J. Magn. Magn. Mater. 225, 30 (2001).
J. Popplewell and L. Sakhnani, J. Magn. Magn. Mater. 149, 72 (1995).
C. W. Jung and P. Jacobs, Magn. Res. Imag. 13, 661 (1995).
S. W. Hong and Ilsu Rhee, Inter. J. Mag. Res. Imag. 1, 15 (2007).
S. F. Chin, M. Makha, C. L. Raston and M. Saunders, Chem. Commun. 1948 (2007).
S. Hong and I. Rhee, J. Korean Phys. Soc. 51, 1453 (2007).
J. Choi, J. C. Kim, Y. B Lee, I. S. Kim, Y. K. Parka and N. H. Hur, Chem. Commun. 1644 (2007).
T. Ahmad, I. Rhee, S. Hong, Y. Chang and J. Lee, J. Nanosci. Nanotech. 11, 5645 (2011).
T. Ahmad, I. Rhee, S. Hong, Y. Chang and J. Lee, J. Korean Phys. Soc. 57, 1545 (2010).
S. F. Chin, K. S. Iyer and C. L. Raston, Crystal Growth & Design 9, 2685 (2009).
M. C. Daniel and D. Astruc, Chem. Rev. 104, 293 (2004).
Y. Xia, B. Gates, Y. Yin and Y. Lu, Adv. Mater. 12, 693 (2000).
D. S. Grubisha, R. J. Lipert, H. Y. Park, J. Driskell and M. D. Porter, Anal. Chem. 75, 5936 (2003).
Z. C. Xu, Y. L. Hou and S. H. Sun, J. Am. Chem. Soc. 129, 8698 (2007).
J. Zhang, M. Post, T. Veres, Z. J. Jakubek, J. Guan, D. Wang, F. Normandin, Y. Deslandes and B. Simard, J. Phys. Chem. B 110, 7122 (2006).
M. Spasova, V. Salgueirino-Maceira, A. Schlachter, M. Hilgendorff, M. Giersig, L. M. Liz-Marzan and M. Farle, J. Mater. Chem. 15, 2095 (2005).
W. Lee, M. G. Kim, J. Choi, J. Park, S. J. Ko, S. J. Oh and J. Cheon, J. Am. Chem. Soc. 127, 16090 (2005).
L. Y. Wang, J. Luo, Q. Fan, M. Suzuki, I. S. Suzuki, M. H. Engelhard, Y. H. Lin, N. Kim, J. Q. Wang and C. J. Zhong, J. Phys. Chem. B 109, 21593 (2005).
S. J. Cho, A. M. Shahin, G. J. Long, J. E. Davies, K. Liu, F. Grandjean and S. M. Kauzlarich, Chem. Mater. 18, 960 (2006).
C. J. O’Connor, V. Kolesnichenko, E. Carpenter, C. Sangregorio, W. Zhou, A. Kumbhar, J. Sims and F. Agnoli, Synth. Met. 122, 547 (2001).
J. Lin, W. Zhou, A. Kumbhar, J. Wiemann, J. Fang, E. E. Carpenter and C. J. O’Connor, J. Solid State Chem. 159, 26 (2001).
G. K. Kouassi and J. Irudayaraj, Anal. Chem. 78, 3234 (2006).
V. M. Burojeanu, L. Fournes, A. Wattiaux, J. Etourneau and E Segal, Inter. J. Inorg. Mater. 3, 525 (2001).
B. Aslibeiki, P. Kameli, H. Salamati, M. Eshraghi and T. Tahmasebi, J. Mag. Mag. Mater. 322, 2929 (2010).
C. K. Lo, D. Xiao and M. M. F. Choi, J. Mater. Chem. 17, 2418 (2007).
S. S. Shankar, A. Ahmad, R. Pasricha, M. I. Khan, R. Kumar and M. Sastry, J. Colloid Interface Sci. 274, 69 (2004).
A. Kumar, S. Mandal, P. R. Selvakannan, R. Pasricha, A. B. Mandale and M. Sastry, Langmuir 19, 6277 (2003).
C. Yang, R. Jie, L. Jianbo and L. Yan, Mat. Lett. 64, 1570 (2010).
H. Chen and J. He, J. Phys. Chem. C 112, 17540 (2008).
Y. Okuhata, Adv. Drug Delivery Rev. 37, 121 (1999).
The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, edited by A. E. Merbach and E. Toth (John Wiley & Sons, Ltd., New York, 2001).
T. Ahmad, H. Bae, I. Rhee, Y. Chang, J. Lee and S. Hong, Curr. Appl. Phys. 12, 969 (2012).
M. Suzuki, S. Wataru, K. Yoshio, H. Hiroyuki and K. Takeshi, Bull. Chem. Soc. Jpn. 69, 1143 (1996).
K. E. Kellar, D. K. Fujii, W. H. Gunther, K. B. Sb, A. Bjrnerud, M. Spiller and S. H. Koenig, J. Magn. Res. Imag. 11, 488 (2000).
S. Laurent, D. Forge, M. Port, A. Roch, C. Robic, L. V. Elst and R. N. Muller, Chem. Rev. 108, 2064 (2008).
A. J. L. Villaraza, A. Bumb and M. W. Brechbiel, Chem. Rev. 110, 2921 (2010).
G. P. Yan, L. Robinson and P. Hogg, Radiography 13, e5 (2007).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ahmad, T., Iqbal, Y., Bae, H. et al. Relaxivities of hydrogen protons in aqueous solutions of gold-coated manganese ferrite nanoparticles. Journal of the Korean Physical Society 62, 1696–1701 (2013). https://doi.org/10.3938/jkps.62.1696
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.3938/jkps.62.1696