Abstract
Rats were fixed with chronically indwelling bipolar electrodes. After recovery from surgery they were trained to leverpress for intracranial stimulation (ICS). They pressed twice a day for three intensities of ICS for 5 min at each intensity. On each day for 10 days prior to tests with ICS, one group of rats was given THC (10 mg/kg, orally) and the other a placebo. The THC led to reduced pressing with initial doses but not with the later doses. Rats with electrode tips in the lateral hypothalamus near the entopeduncular nucleus of the internal capsule showed accelerated pressing toward the end of the 10 days of testing under THC.
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Taylor, P., & Reid, L. Daily THC and pressing for hypothalamic ICS: A pilot study. Unpublished observations.
Rosenkrantz, H. Personal communication, May 24, 1976.
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This study was supported by Grant DA01049 from the National Institute on Drug Abuse, DHEW. We would like to thank Pamela Pidcoe Taylor and Adrienne Wynn for their help in collecting data.
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Becker, B.M., Reid, L.D. Daily l-Δ9-tetrahydrocannabinol and pressing for hypothalamic stimulation. Bull. Psychon. Soc. 10, 325–327 (1977). https://doi.org/10.3758/BF03329350
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DOI: https://doi.org/10.3758/BF03329350