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Sensory, perceptual, motor and cognitive functioning and subjective reports following oral administration ofΔ 9-Tetrahydrocannabinol

  • Human Pharmacology
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Abstract

Three dose levels, 0.2, 0.4 and 0.6 mg/kg, ofΔ 9-tetrahydrocannabinol (THC) and a placebo were orally administered to 10 frequent and 10 occasional marijuana users. Following ingestion of each dose and the placebo, objective tests selected from a battery of sensory and perceptual motor tests routinely used to evaluate cerebral dysfunction in hospitalized patients were administered. The influence ofΔ 9-THC on proficiency and variability of performance was minimal. However, when individual test scores and variabilities were combined and converted to standard scores, allowing for analysis of overall performance, THC had a small but consistent detrimental effect on both proficiency and variability of performance. In contrast, THC exerted profound effects on the subjective experiences of the volunteers as assessed by the Subjective Drug Effects Questionnaire. Subjective changes in mood, feeling, perception and somatic sensations were reported by all subjects but were more pronounced in the occasional user group. It was proposed that the small impairment noted in objective test performance after ingestion ofΔ 9-THC as contrasted to the large effects on subjective responses suggests that the principal effects of marijuana are on the autonomic nervous system rather than on higher cortical functions.

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References

  • Abel, E. L.: Marijuana and memory. Nature (Lond.)227, 1151–1152 (1970)

    Google Scholar 

  • Aldrich, C. K.: The effect of a synthetic marihuana-like compound on musical talent as measured by the Seashore Test. Publ. Hlth Rep. (Wash.)59, 431–433 (1944)

    Google Scholar 

  • Caldwell, D. F., Myers, S. A., Domino, E. F., Merriam, P. E.: Auditory and visual threshold effects of marihuana in man. Percept. Mot. Skills29, 755–759 (1969)

    Google Scholar 

  • Clark, L. D., Hughes, R., Nakashima, E. N.: Behavioral effects of marihuana. Amer. J. Psychiat.23, 193–198 (1970)

    Google Scholar 

  • Clark, L. D., Nakashima, E. N.: Experimental studies of marihuana. Amer. J. Psychiat.125, 379–384 (1968)

    Google Scholar 

  • Clark, S. C.: Theoretical review: Marihuana and the cardiovascular system. Pharmacol. Biochem. Behav.3, 299–306 (1975)

    Google Scholar 

  • Crancer, A., Jr., Dille, J. M., Delay, J. C., Wallace, J. E., Haykin, M. D.: Comparison of the effects of marihuana and alcohol on simulated driving performance. Science164, 851–854 (1969)

    Google Scholar 

  • Goldstein, G., Russell, E. W., Shelly, C. H., Neuringer, C.: A crossvalidation of the Halstead battery in a veteran population. A paper presented at the 14th Annual Conference, VA Cooperative Studies in Psychiatry Spring 1969

  • Goldstein, G., Shelly, C. H.: Statistical and normative studies of the Halstead Neuropsychological test Battery relevant to a neuropsychiatric hospital setting. Percept. Mot. Skills34, 603–620 (1972)

    Google Scholar 

  • Grant, I., Rochford, J., Fleming, T., Stunkard, A.: A neuropsychological assessment of the effects of moderate marihuana use. J. nerv. ment. Dis.156, 278–280 (1973)

    Google Scholar 

  • Grove-White, I. G., Kelman, G. R.: Critical flicker frequency after small doses of methohexitone, diazepam and sodium 4-hydroxy-butyrate. Brit. J. Anaesth.43, 110–112 (1971)

    Google Scholar 

  • Grundvig, J. L., Needham, W. E., Ajax, E. T., Beck, E. C.: The use of the Sensory-Perceptual Examination in dingnosis of degree of impairment of higher cerebral functions. J. nerv. ment. Dis.151, 114–119 (1970)

    Google Scholar 

  • Halstead, W. C.: Brain and intelligence: A quantitative study of frontal lobes. Chicago: University of Chicago Press 1947

    Google Scholar 

  • Hollister, L. E., Gillespie, H. K.: Marihuana, ethanol, and dextroamphetamine. Arch. gen. Psychiat.23, 199–203 (1970)

    Google Scholar 

  • Hollister, L. E., Richards, R. K., Gillespie, H. K.: Comparison of tetrahydrocannabinol and synhexyl in man. Clin. Pharmacol. Ther.9, 783–791 (1968)

    Google Scholar 

  • Ideström, C.-M., Cadenius, B.: Time relations of the effects of alcohol compared to placebo. Psychopharmacologia (Berl.)13, 189–200 (1968)

    Google Scholar 

  • Jones, R. T.: Marihuana-induced “high”: Influence of expectation, setting and previous drug experience. Pharmacol. Rev.23, 359–369 (1971)

    Google Scholar 

  • Jones, R. T., Stone, G. C.: Psychological studies of marijuana and alcohol in man. Psychopharmacologia (Berl.)18, 108–117 (1970)

    Google Scholar 

  • Katz, M. M., Waskow, I. E., Olsson, J.: Characterizing the psychological state produced by LSD. J. abnorm. Psychol.73, 1–14 (1968)

    Google Scholar 

  • Klonoff, H., Low, M., Marcus, A.: Neuropsychological effects of marijuana. Canad. med. Ass. J.108, 150–156 (1973)

    Google Scholar 

  • Kløve, H.: Validation studies in adult clinical neuropsychology. In: Clinical neuropsychology current status and application, Reitan and Davison, eds. Washington, D.C.: Winston 1974

    Google Scholar 

  • Kramer, C. Y.: Extension of multiple range tests to group correlated adjusted means. Biometrics13, 13–18 (1957)

    Google Scholar 

  • Lehmann, H. E., Csank, J.: Differential screening of phrenotropic agents in man: Psychophysiologic test data. J. clin. exp. Psychopath.18, 222–235 (1957)

    Google Scholar 

  • Lewis, E. G., Dustman, R. E., Beck, E. C.: The effect of alcohol on sensory phenomena and cognitive and motor tasks. Quart. J. Stud. Alcohol30, 618–633 (1969)

    Google Scholar 

  • Lloyd, D. N., Newbrough, J. R.: Sensory changes with phenothiazine medication in schizophrenic patients. J. nerv. ment. Dis.139, 169–175 (1964)

    Google Scholar 

  • Mackie, J. B.: A comparative study of brain damage and normal individuals on tests of intelligence, perception and rigidity. Unpublished doctoral dissertation. Salt Lake City: University of Utah 1963

    Google Scholar 

  • Mackie, J. B., Beck, E. C.: Relations among age, intelligence and critical flicker fusion. Percept. Mot. Skills21, 875–878 (1965)

    Google Scholar 

  • Mackie, J. B., Beck, E. C.: Relations among rigidity, intelligence and perception in brain damaged and normal individuals. J. nerv. ment. Dis.142, 310–317 (1966)

    Google Scholar 

  • Malit, L. A., Johnstone, R. F., Bourke, D. I., Kulp, R. A., Klein, D., Eng, D., Smith, T. C.: IntravenousΔ 9-tetrahydrocannabinol; Effects on ventilatory control and cardiovascular dynamics. Anesthesiology42, 666–673 (1975)

    Google Scholar 

  • Manno, J. E., Kiplinger, G. G., Haine, S. E., Bennett, I. F., Forney, R. B.: Comparative effects of smoking marihuana or placebo on human motor and mental performance. Clin. Pharmacol. Ther.11, 808–815 (1970)

    Google Scholar 

  • mattews, C. G., Booker, H. E.: Pneumoencephalographic measurements and neuropsychological test performance in human adults. Cortex8, 69–92 (1972)

    Google Scholar 

  • Melges, F. T., Tinklenberg, J. R., Hollister, L. E., Gillespie, H. K.: Temporal disintegration and depersonalization during marihuana intoxication. Arch. gen. Psychiat.23, 204–210 (1970)

    Google Scholar 

  • Meyer, R. E., Pillard, R. C., Shapiro, L. M., Mirin, S. M.: Administration of marijuana to heavy and casual marijuana users. Amer. J. Psychiat.128, 198–204 (1971)

    Google Scholar 

  • Miller, L. L., Drew, W. G.: Cannabis: Neural mechanisms and behavior. In: Marijuana: effects on human behavior, L. Miller, ed., pp. 158–182. New York: Academic Press 1974

    Google Scholar 

  • Newbrough, J. R.: The effect of brain damage upon sensory aftereffect. Unpublished Doctoral Dissertation. Salt Lake City: University of Utah 1959

    Google Scholar 

  • Paton, W. D. H.: Pharmacology of marijuana. Ann. Rev. Pharmacol.25, 191–220 (1975)

    Google Scholar 

  • Reitan, R. M.: An investigation of the validity of Halstead's measure of biological intelligence. Arch. Neurol. Psychiat. (Chic.)73, 28–35 (1955)

    Google Scholar 

  • Reitan, R. M.: Comparative behavioral effects of phenglycodol, meprobamate and placebo. In: Drugs and behavior, L. Uar and J. G. Miller, eds. New York: Wiley 1960

    Google Scholar 

  • Reitan, R. M., Davison, L. A.: Clinical neuropsychology: Current status in application. Washington, D.C., Winston 1974

    Google Scholar 

  • Roback, G. S., Krasno, L. R., Ivy, A. C.: Effect of analeptic drugs on the somnifacient effect of seconal and antihistaminics as measured by the flicker fusion threshold. J. appl. Physiol4, 566–574 (1952)

    Google Scholar 

  • Savage, P., Wilkinson, V.: Reaction time in psychiatric patients: A pilot study. N.Z. med. J.73, 285–288 (1971)

    Google Scholar 

  • Straight, R., Wayne, A. W., Lewis, E. G., Beck, E. C.: Marihuana extraction and purification for oral administration of known amounts ofΔ 9-tetrahydrocannabinol (THC). Biochem. Med.8, 341–344 (1973)

    Google Scholar 

  • Sutton, D., Burns, J.: Alcohol dose effects on feedback-maintained simple reaction time. J. Psychol.78, 151–159 (1971)

    Google Scholar 

  • Tinklenberg, J. R., Kopell, B. S., Melges, F. T., Hollister, L. E.: Marihuana and alcohol. Arch. gen. Psychiat.27, 812–815 (1972)

    Google Scholar 

  • Tinklenberg, J. R., Melges, F. T., Hollister, L. E., Gillespie, H. K.: Marihuana and immediate memory. Nature (Lond.)266, 1171–1172 (1970)

    Google Scholar 

  • Vega, A., Parsons, O. A.: Cross validation of the Halstead-Reitan Test for brain damage. J. cons. Psychol.31, 619–625 (1967)

    Google Scholar 

  • Waskow, I. E., Olsson, J. E., Salzman, C., Katz, M. M.: Psychological effects of tetrahydrocannabinol. Arch. gen. Psychiat.22, 97–107 (1970)

    Google Scholar 

  • Weil, A. T., Zinberg, N. E., Nelson, J. M.: Clinical and psychological effects of marihuana in man. Science162, 1234–1242 (1968)

    Google Scholar 

  • Wheeler, L., Burke, C. J., Reitan, R. M.: An application of discriminant functions to the problem of predicting brain damage using behavioral variables. Percept. Mot. Skills16, 417–440 (1963)

    Google Scholar 

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Authors and Affiliations

  1. Neuropsychology Research Laboratories and University of Utah, Veterans Administration Hospital, Salt Lake City, Utah

    B. A. Peters, E. G. Lewis, R. E. Dustman, R. C. Straight & E. C. Beck

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  1. B. A. Peters
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  2. E. G. Lewis
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  3. R. E. Dustman
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  4. R. C. Straight
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  5. E. C. Beck
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Additional information

Veterans Administration approved Research Project 0864-03. Also supported by U.S. Public Health Service Research Grant No. DA000.56 from the National Institute of Mental Health.

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Peters, B.A., Lewis, E.G., Dustman, R.E. et al. Sensory, perceptual, motor and cognitive functioning and subjective reports following oral administration ofΔ 9-Tetrahydrocannabinol. Psychopharmacology 47, 141–148 (1976). https://doi.org/10.1007/BF00735812

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  • DOI: https://doi.org/10.1007/BF00735812

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