Abstract
Four groups of rats were exposed to a highly ulcerogenic procedure. Three experimental groups were given programmed injections of three different concentrations of chlorpromazine and a control group received physiological saline. All drug concentrations significantly reduced ulceration relative to controls. The lowest concentration proved least effective in this regard, but no simple linear relationship was found between drug concentration and frequency of ulceration. A tentative hypothesis regarding an all-or-none protective function of the drug was suggested, and parameters for future research outlined.
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Shemberg, K., Green, P.C. & Gliner, J. A note on the effects of chlorpromazine upon ulceration in the rat. Psychon Sci 20, 272–273 (1970). https://doi.org/10.3758/BF03329062
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DOI: https://doi.org/10.3758/BF03329062