Abstract
The selective D-1 dopamine antagonist SCH 23390 caused a rapid but progressive increase in mean latency to initiate eating and an almost immediate decrease in mean time to complete the eating of five 45-mg food pellets within 36-sec meal segments in food-deprived rats. While mean scores were slowed, normal latencies and speeds were still noted in a significant portion of trials. The drug did not decrease the absolute limits of peak performance; rather, it increased the variance of both response measures. While the effects of SCH 23390 developed more quickly than those reported for the preferential D-2 blocker pimozide, the effects were qualitatively similar and consistent with emerging views of interaction between D-1 and D-2 receptor mechanisms and of the involvement of dopamine in motivational aspects of behavior.
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Koechling, U., Colle, L.M. & Wise, R.A. Effects of SCH 23390 on motivational aspects of deprivation-induced feeding. Psychobiology 16, 207–212 (1988). https://doi.org/10.3758/BF03327308
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DOI: https://doi.org/10.3758/BF03327308