Skip to main content

Advertisement

SpringerLink
Log in

Quality of life is impaired not only in vitamin D deficient but also in vitamin D-insufficient pre-menopausal women

  • Original Article
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

Background: Vitamin D deficiency may be more common in pre-menopausal women than previously thought and it may impair quality of life (QoL). Aim: The aim of this study is to evaluate QoL in pre-menopausal women with vitamin D deficiency and insufficiency. Subjects and methods: This is a cross-sectional study in which subjects were enrolled between September 1st and November 30th, 2011. Healthy pre-menopausal women with weakness, fatigue and non-specific pain were assigned into three groups according to their 25-hydroxyvitamin D (25-OHD) levels: ≤20 ng/ml (vitamin D deficient, no.=30), 21–29 ng/ml (vitamin D insufficient, no.=30) and ≥30 ng/ml (vitamin D sufficient, no.=20). Short form-36 (SF-36) scores, age, calcium (Ca), phosphorus (P), and PTH levels were compared among the groups and correlations of SF-36 scores with age, serum 25-OHD, Ca, P, and PTH were done. Results: There were significant differences among the groups with regard to PTH (p=0.008), physical component score (p=0.02), mental component score (p=0.035), physical functioning score (p=0.0001), and vitality score (p=0.05). Apart from PTH and physical functioning score, the results were significant when vitamin D-insufficient and -sufficient women were compared. Serum 25-OHD, but not PTH was correlated with some of the scales of SF-36. Conclusions: Some components of QoL are impaired not only in vitamin D deficient but also in insufficient pre-menopausal women, and impairment is related to 25-OHD rather than PTH levels.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Adams JS, Hewison M. Update in vitamin D. J Clin Endocrinol Metab 2010, 95: 471–8.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Shinchuk LM, Holick MF. Vitamin D and rehabilitation: improving functional outcomes. Nutr Clin Pract 2007, 22: 297–304.

    Article  PubMed  Google Scholar 

  3. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011, 96: 1911–30.

    Article  PubMed  Google Scholar 

  4. Lips P, Hosking D, Lippuner K, et al. The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation. J Intern Med 2006, 260: 245–54.

    Article  PubMed  Google Scholar 

  5. Forrest KYZ, Stuhldreher WL. Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res 2011, 31: 48–54.

    Article  PubMed  Google Scholar 

  6. Nair R, Maseeh A. Vitamin D: the “sunshine” vitamin. J Pharmacol Pharmacother 2012, 3: 118–26.

    PubMed Central  PubMed  Google Scholar 

  7. Zamboni M, Zoico E, Tosoni P, et al. Relation between vitamin D, physical performance, and disability in elderly persons. J Gerontol A Biol Sci Med Sci 2002, 57: M7–11.

    Article  PubMed  Google Scholar 

  8. Bossola M, Ciciarelli C, Conte GL, Vulpio C, Luciani G, Tazza L. Correlates of depression and anxiety in chronic hemodialysis patients. Gen Hosp Psychiatry 2010, 32: 125–31.

    Article  PubMed  Google Scholar 

  9. Witham MD, Crighton LJ, Gillespie ND, Struthers AD, McMurdo MET. The effects of vitamin D supplementation on physical function and quality of life in older patients with heart failure: a randomized controlled trial. Circ Heart Fail 2010, 3: 195–201.

    Article  PubMed  Google Scholar 

  10. Anand S, Kaysen GA, Chertow GM, et al. Vitamin D deficiency, self-reported physcial activity and health-related quality of life: the Comprehensive Dialysis Study. Nephrol Dial Transplant 2011, 26: 3683–8.

    Article  PubMed Central  PubMed  Google Scholar 

  11. Sakalli H, Arslan D, Yucel AE. The effect of oral and parenteral vitamin D supplementation in the elderly: a prospective, double-blinded, randomized, placebo-controlled study. Rheumatol Int 2012, 32: 2279–83.

    Article  PubMed  Google Scholar 

  12. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961, 4: 561–71.

    Article  PubMed  Google Scholar 

  13. Ware JE jr, Sherbourne CD. The MOS 36-item short-form health survey. I. Conceptual framework and item selection. Med Care 1992, 30: 473–83.

    Article  PubMed  Google Scholar 

  14. Kocyigit H, Aydemir O, Fisek G, Olmez N, Memis A. Validation and reliability of Turkish version of Short Form-36 (SF-36). Ilaçve Tedavi Dergisi (Drug and Treatment Journal) 1999, 12: 102–6 (In Turkish).

    Google Scholar 

  15. Ware JE jr, Gandek B, for the IQOLA Project. Overview of the SF-36 health survey and the International Quality of Life Assessment (IQOLA) Project. J Clin Epidemiol 1998, 51: 903–12.

    Article  PubMed  Google Scholar 

  16. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int 2005, 16: 713–6.

    Article  PubMed  Google Scholar 

  17. Kenny AM, Biskup B, Robbins B, Marcella G, Burleson JA. Effects of vitamin D supplementation on strength, physical function, and health perception in older, community-dwelling men. J Am Geriatr Soc 2003, 51: 1762–7.

    Article  PubMed  Google Scholar 

  18. Wicherts IS, van Schoor NM, Boeke AJP, et al. Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab 2007, 92: 2058–65.

    Article  PubMed  Google Scholar 

  19. Houston DK, Cesari M, Ferruci L, et al. Association between vitamin D status and physical performance: The In CHIANTI Study. J Gerontol A Biol Sci Med Sci 2007, 62: 440–6.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Straube S, Moore RA, Derry S, McQuay HJ. Vitamin D and chronic pain. Pain 2009, 141: 10–3.

    Article  PubMed  Google Scholar 

  21. Landsdowne ATG, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology 1998, 135: 319–23.

    Article  Google Scholar 

  22. Wilkins CH, Sheline YI, Roe CM, Birge SJ, Morris JC. Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry 2006, 14: 1032–40.

    Article  PubMed  Google Scholar 

  23. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001, 22: 477–501.

    Article  PubMed  Google Scholar 

  24. McCarty MF. Secondary hyperparathyroidism promotes the acute phase response — a rationale for supplemental vitamin D in prevention of vascular events in the elderly. Med Hypotheses 2005, 64: 1022–6.

    Article  PubMed  Google Scholar 

  25. Sahota O, Gaynor K, Harwood RH, Hosking DJ. Hypovitaminosis D and ‘functional hypoparathyroidism’ — the NoNoF (Nottingham Neck of Femur) study. Age Ageing 2001, 30: 467–72.

    Article  PubMed  Google Scholar 

  26. Sahota O, Mundey MK, San P, Godber IM, Lawson N, Hosking DJ. The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density, in postmenopausal women with established osteoporosis. Bone 2004, 35: 312–9.

    Article  PubMed  Google Scholar 

  27. Rejnmark L, Vestergaard P, Brot C, Mosekilde L. Parathyroid response to vitamin D insufficiency: relations to bone, body composition and lifestyle characteristics. Clin Endocrinol 2008, 69: 29–35.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Ondokuz Mayis University School of Medicine, Kurupelit, Samsun, 55139, Turkey

    G. C. Ecemis & A. Atmaca MD

Authors
  1. G. C. Ecemis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Atmaca MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Atmaca MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ecemis, G.C., Atmaca, A. Quality of life is impaired not only in vitamin D deficient but also in vitamin D-insufficient pre-menopausal women. J Endocrinol Invest 36, 622–627 (2013). https://doi.org/10.3275/8898

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.3275/8898

Key-words

Search

Navigation