Skip to main content
SpringerLink
Log in

Influence of the external noise intensity on the kinetics of ligands binding to receptors

  • Published:
Journal of Contemporary Physics (Armenian Academy of Sciences) Aims and scope

Abstract

The average, variance, correlation function and the spectral density of ligand–receptor complexes in the presence of the external Langevin noise are calculated and their characteristics are defined. The analysis of the experimental data using the formulas derived in this work enables one to obtain a new information on the process of forming of ligand–receptor complex, namely, the constants rates of formation and the decay of the ligand–receptor complex.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Chattopadhyay, A., Advances in Biology, 2014, vol. 2014, Article ID 143023, 12 pages.

    Article  Google Scholar 

  2. Humphrey, P.P.A. and Barnard, E.A., Pharmacol. Reviews, 1998, vol. 50, p. 271.

    Google Scholar 

  3. Berg, H.C. and Purcell, E.M., Biophys. J., 1977, vol. 20, p. 193.

    Article  ADS  Google Scholar 

  4. Varfolomeev, S.D. and Gurevich, K.G., Biokinetika (Biokinetics), Moscow, FAIR-Press, 1999.

    Google Scholar 

  5. Cell Signaling Reactions: Single-Molecular Kinetic Analysis, Y. Sako, M. Ueda, Eds., Springer Science+ Business Media, 2011.

  6. De la Rubia, J. and Velarde, M.G., Phys. Lett. A, 1978, vol. 69, p. 304.

    Article  ADS  MathSciNet  Google Scholar 

  7. Kitahara, K., Horsthemke, W., Lefever, R., and Inaba, Yu., Prog. Theor. Phys., 1980, vol. 64, p. 1233.

    Article  ADS  Google Scholar 

  8. Rappel, W.-J. and Levine, H., PNAS, 2008, vol. 105, p. 19270.

    Article  ADS  Google Scholar 

  9. Horsthemke, W. and Lefever, R., Noise-Induced Transitions, Berlin, Heidelberg, New York, Tokyo: Springer-Verlag 1984.

    MATH  Google Scholar 

  10. Arakelyan, V.B., Haroutiunian, S.G., Arakelyan, H.V., and Haroutunyan, T.S., J. Biomol. Struct. Dyn., 2002, vol. 20, p. 125.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Yerevan State University, Yerevan, Armenia

    V. B. Arakelyan & R. P. Grigoryan

  2. Krasnodar Branch of the Plekhanov Russian University of Economics, Krasnodar, Russia

    V. P. Danko

Authors
  1. V. B. Arakelyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. P. Danko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. P. Grigoryan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. B. Arakelyan.

Additional information

Original Russian Text © V.B. Arakelyana, V.P. Danko, R.P. Grigoryan, 2017, published in Izvestiya Natsional'noi Akademii Nauk Armenii, Fizika, 2017, Vol. 52, No. 1, pp. 94–101.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Arakelyan, V.B., Danko, V.P. & Grigoryan, R.P. Influence of the external noise intensity on the kinetics of ligands binding to receptors. J. Contemp. Phys. 52, 70–75 (2017). https://doi.org/10.3103/S106833721701011X

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.3103/S106833721701011X

Keywords

Search

Navigation