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Genetic determining of the change in VE-cadherin expression and intensified vessel deendothelisation during hemorrhagic fever with renal syndrome

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Abstract

This paper studies the dependence of the level of vascular endothelial cadherin (VE-cadherin) in the blood serum and the degree of endothelial desquamation on the frequency distribution of genotypes and alleles of the polymorphic locus rs1049970 of the VE-cadherin CDH5 gene during hemorrhagic fever with renal syndrome (HFRS) of varying severity. The VE-cadherin concentration statistically significantly drops; the number of circulating endothelial cells increases in the dynamics of HFRS in all degrees of severity of the disease, most significantly, in the severe form with complications. A strong negative correlation is revealed between them. The frequency of occurrence of the homozygous genotype *T/*T is significantly high only in the severe form with complications. It was concluded that there is a correlation between the decrease in the VE-cadherin level in the blood serum and the increase in the vessel endothelial desquamation during moderate to severe and severe uncomplicated HFRS with decreased expression of VE-cadherin on endothelial cells. It may be that missense mutation c.1550T > C of the VE-cadherin gene in the severe form with complications increases the desquamation process of endothelial cells.

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Authors and Affiliations

  1. Ministry of Health and Social Development of the Russian Federation, Bashkir State Medical University, Ufa, Bashkortostan, Russia

    A. A. Baigil’dina

  2. Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences, Ufa, Bashkortostan, Russia

    D. V. Islamgulov

Authors
  1. A. A. Baigil’dina
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  2. D. V. Islamgulov
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Correspondence to A. A. Baigil’dina.

Additional information

Original Russian Text © A.A. Baigil’dina, D.V. Islamgulov, 2012, published in Molekulyarnaya Genetika, Mikrobiologiya i Virusologiya, 2012, No. 4, pp. 23–27.

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Baigil’dina, A.A., Islamgulov, D.V. Genetic determining of the change in VE-cadherin expression and intensified vessel deendothelisation during hemorrhagic fever with renal syndrome. Mol. Genet. Microbiol. Virol. 27, 160–166 (2012). https://doi.org/10.3103/S0891416812040027

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  • DOI: https://doi.org/10.3103/S0891416812040027

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