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The evolution of the Vibrio cholerae genome during the modern period

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Abstract

A review of the modern data concerning the phenotypical and genetic peculiarities of the recently emerged highly virulent variants of V. cholerae El-Tor biovar (the etiological agent of the current cholera pandemic) is presented. The molecular-genetic mechanisms that are considered to be a basis for V. cholerae genome evolution during the modern period are discussed. The transposon role in the increased expression of cholera toxin genes, which are constituents of the CTXφ prophage genome, is addressed. The need to work out new gene-diagnostic test-systems for the identification of natural altered variants of the cholera etiological agent is shown.

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References

  1. Baroyan, O.V., Kholera El’-Tor (Cholera El Thor), Moscow, 1971.

  2. Goryaev, A.A., Shchelkanova, E.Yu., Lozovskii, Yu.V., et al., Prob. Osobo Opasn. Infektsii, 2008, no. 95, pp. 56–59.

  3. Il’ina, T.S., Mol. Genet., 2003, no. 4, pp. 3–10.

  4. Kutyrev, V.V., Smirnova, N.I., and Cherkasskii, B.L., Epidemiol. Infekts. Bol., 2006, no. 4, pp. 43–47.

  5. Onishchenko, G.G., Lomov, Yu.M., Moskvitina, E.A., et al., Zh. Mikrobiol. Epidemiol. Immunobiol., 2005, no. 3, pp. 4–48.

  6. Smirnov, G.B., Usp. Sovrem. Biol., 2008, vol. 128, no. 1, pp. 52–76.

    Google Scholar 

  7. Smirnova, N.I., Mol. Genet., 1999, no. 4, pp. 3–10.

  8. Smirnova, N.I. and Kutyreva, V.V., Mol. Genet., 2004, no. 4, pp. 3–13.

  9. Shchelkanova, E.Yu., Goryaev, A.A., and Smirnova, N.I., Mol. Genet., 2008, no. 4, pp. 23–33.

  10. Ansaruzzaman, M., Bhuiyan, N.A., Nair, B.G., et al., Amerg. Infect. Dis., 2004, vol. 10, pp. 2057–2059.

    CAS  Google Scholar 

  11. Bani, S., Mastromarino, P.N., Ceccarelli, D., et al., FEMS Microbiol. Letts., 2007, vol. 266, pp. 42–48.

    Article  CAS  Google Scholar 

  12. Beyhan, S., Tischler, A.D., Camilli, A., and Yildiz, F.H., Infect. Immun., 2006, vol. 74, no. 6, pp. 3633–3642.

    Article  CAS  PubMed  Google Scholar 

  13. Blokesch, M. and Schoolnik, G.K., PloS Pathog., 2007, vol. 3, pp. 0733–0742.

    Article  CAS  Google Scholar 

  14. Blokesch, M. and Schoolnik, G.K., J. Bacteriol., 2008, vol. 190, no. 21, pp. 7232–7240.

    Article  CAS  PubMed  Google Scholar 

  15. Campos, J., Fando, R., Silva, A., et al., FEMS Microbiol. Letts., 1998, vol. 164, pp. 141–147.

    CAS  Google Scholar 

  16. Choi, S.Y., Lee, H.J., Kim, E.J., et al., J. Med. Microbiol., 2010, vol. 59, pp. 302–308.

    Article  CAS  PubMed  Google Scholar 

  17. Chun, J., Grim, C.J., Hasan, N.A., et al., Proc. Natl. Acad. Sci. USA, 2009, vol. 106, no. 36, pp. 15442–15447.

    Article  CAS  PubMed  Google Scholar 

  18. Das, B., Bischerour, J., Val, M.E., and Barre, F.X., Proc. Natl. Acad. Sci. USA, 2010, vol. 107, no. 9, pp. 4377–4382.

    Article  CAS  PubMed  Google Scholar 

  19. De Haan, L. and Hirst, T.R., Mol. Membr. Biol., 2004, vol. 21, no. 2, pp. 77–92.

    Article  PubMed  Google Scholar 

  20. Dziejman, M., Balon, E., Boyd, D., et al., Proc. Natl. Acad. Sci. USA, 2002, vol. 99, no. 3, pp. 1556–1561.

    Article  CAS  PubMed  Google Scholar 

  21. Ehara, M., Cholerae, Variant Strains, Viet Nam: (North). Cholerae, Diarrhea and Dysentery Update, 2008, no. 9, pp. 157–168.

  22. Farugue, S.M., Albert, M.J., and Mekalanos, J.J., Microbiol. Mol. Biol. Rev., 1998, vol. 62, pp. 1301–1314.

    Google Scholar 

  23. Faruque, S.M., Kamruzzaman, M., Asadulhgani, M., et al., Proc. Natl. Acad. Sci. USA, 2003, vol. 100, pp. 1280–1285.

    Article  CAS  PubMed  Google Scholar 

  24. Faruque, S.M., Tam, V.C., Chowdhury, N., et al., Proc. Natl. Acad. Sci. USA, 2007, vol. 104, no. 12, pp. 5151–5156.

    Article  CAS  PubMed  Google Scholar 

  25. Feng, L., Reeves, P.R., Lan, R., et al., PLos One, 2008, vol. 3, no. 12, pp. 1–11.

    Article  Google Scholar 

  26. Halder, K., Das, B., Nair, G.B., Bhadra, R.K, Microbiology, 2010, vol. 156, pp. 99–107.

    Article  CAS  PubMed  Google Scholar 

  27. Heidelberg, J.F., Eisen, J.A., Nelson, W.C., et al., Nature, 2000, vol. 406, pp. 477–483.

    Article  CAS  PubMed  Google Scholar 

  28. Heilpern, A.J. and Waldor, M.K., J. Bacteriol., 2003, vol. 185, no. 3, pp. 1037–1044.

    Article  CAS  PubMed  Google Scholar 

  29. Kaper, J.B., Morris, J.G., and Leivne, M.M., Clin. Microbiol. Rev., 1995, vol. 8, no. 1, pp. 48–86.

    CAS  PubMed  Google Scholar 

  30. Karaolis, D.K., Lan, R., and Reeves, P.R., J. Bacteriol., 1994, vol. 176, no. 20, pp. 3191–3198.

    Google Scholar 

  31. Karaolis, D.K. and Kaper, J.B., Trends Microbiol., 1999, vol. 7, p. 393.

    Article  PubMed  Google Scholar 

  32. Kimsey, H.H. and Waldor, M.K., Proc. Natl. Acad. Sci. USA, 1998, vol. 95, no. 2, pp. 7035–7039.

    Article  CAS  PubMed  Google Scholar 

  33. Kumar, P., Jain, M., Goel, A.K., et al., J. Med. Microbiol., 2009, vol. 58, pp. 234–238.

    Article  CAS  PubMed  Google Scholar 

  34. Lee, H.J., Han, K.H., Choi, S.Y., et al., J. Med. Microbiol., 2006, vol. 55, pp. 165–170.

    Article  CAS  PubMed  Google Scholar 

  35. Lee, H.J., Choi, S.Y., and Jeon, Y.S., J. Microbiol., 2009, vol. 47, no. 6, pp. 783–788.

    Article  CAS  PubMed  Google Scholar 

  36. Lin, W., Fullner, K.J., Clayton, R., et al., Proc. Natl. Acad. Sci. USA, 1999, vol. 96, no. 3, pp. 1071–1076.

    Article  CAS  PubMed  Google Scholar 

  37. Longini, I.M., Yunus, M., Zaman, K., et al., J. Infect. Dis., 2002, vol. 186, pp. 246–251.

    Article  PubMed  Google Scholar 

  38. Meibom, K.L., Blokesch, M., Dolganov, N.A., et al., Science, 2005, vol. 310, pp. 1824–1827.

    Article  CAS  PubMed  Google Scholar 

  39. Nair, G.B., Faruque, S.M., Bhuiyan, N.A., et al., J. Clin. Microbiol., 2002, vol. 40, pp. 3296–3299.

    Article  PubMed  Google Scholar 

  40. Nair, G.B., Qadri, F., Holmgren, J., et al., J. Clin. Microbiol., 2006, vol. 44, pp. 4211–4213.

    Article  CAS  PubMed  Google Scholar 

  41. Nair, G.B., Bhuiyan, N.A., Nusrin, S., et al., in Vibrio 2007, Gevers, D., et al., Eds., Paris, 2007, p. 25.

  42. Nguyen, B.M., Lee, J.H., Cuong, N.T., et al., J. Clin. Microbiol., 2009, vol. 47, no. 5, pp. 1568–1571.

    Article  CAS  PubMed  Google Scholar 

  43. Nusrin, S., Khan, G.Y., Bhuiyan, N.A., et al., J. Clin. Microbiol., 2004, vol. 42, no. 12, pp. 5854–5856.

    Article  PubMed  Google Scholar 

  44. Olsvik, O., Wahlberg, J., Petterson, B., et al., J. Clin. Microbiol., 1993, vol. 31, pp. 22–25.

    CAS  PubMed  Google Scholar 

  45. Pradhan, S., Baidya, A.K., Ghosh, A., et al., J. Bacteriol., 2010, vol. 192, no. 4, pp. 955–963.

    Article  CAS  PubMed  Google Scholar 

  46. Rawlings, T.K., Ruiz, G.M., and Colwell, R.R., Appl. Environ. Microbiol., 2007, vol. 73, pp. 7926–7933.

    Article  CAS  PubMed  Google Scholar 

  47. Raychoudhuri, A., Mukhopadhyay, A.K., Ramamurthy, T., et al., Indian J. Med. Res., 2008, vol. 128, no. 6, pp. 695–698.

    PubMed  Google Scholar 

  48. Raychoudhuri, A. and Partana, T., Emerg. Infect. Dis., 2009, vol. 15, no. 1, pp. 131–132.

    Article  PubMed  Google Scholar 

  49. Raychoudhuri, A., Mukherjee, P., Ramamurthy, T., et al., FEMS Microbiol. Letts., 2010, vol. 303, no. 2, pp. 107–115.

    Article  CAS  Google Scholar 

  50. Safa, A., Bhuiyan, N.A., Alam, M.A., et al., J. Clin. Microbiol., 2005, vol. 43, pp. 1401–1404.

    Article  CAS  PubMed  Google Scholar 

  51. Safa, A., Bhuiyan, N.A., Nusrin, S., et al., J. Med. Microbiol., 2006, vol. 55, pp. 1563–1569.

    Article  CAS  PubMed  Google Scholar 

  52. Safa, A., Sultana, J., Cam, P.D., et al., Emerg. Infect. Dis., 2008, vol. 14, pp. 987–988.

    Article  PubMed  Google Scholar 

  53. Safa, A., Nair, G.B., and Kong, R.Y., Trends Microbiol., 2010, vol. 18, pp. 46–54.

    Article  CAS  PubMed  Google Scholar 

  54. Salim, A., Lan, R., and Reeves, P.R., Emerg. Infrect. Dis., 2005, vol. 11, pp. 1758–1760.

    Google Scholar 

  55. Taneja, N., Mishra, A., Sangar, G., et al., Emerg. Infect. Dis., 2009, vol. 15, no. 2, pp. 352–354.

    Article  PubMed  Google Scholar 

  56. Trucksis, M., Galen, J.E., Miahalski, J., et al., Proc. Natl. Acad. Sci. USA, 1993, vol. 90, no. 11, pp. 5267–5271.

    Article  CAS  PubMed  Google Scholar 

  57. Udden, S.M.N., Zahid, M.S.H., Biswas, K., et al., Proc. Natl. Acad. Sci. USA, 2008, vol. 105, no. 33, pp. 11951–11956.

    Article  CAS  PubMed  Google Scholar 

  58. Vest, T., Wassenar, T.M., Hallin, P.F., et al., Microbiol. Ecol., 2010, vol. 59, pp. 1–13.

    Article  Google Scholar 

  59. Waldor, M.K. and Mekalanos, J.J., Science, 1996, vol. 272, pp. 1910–1914.

    Article  CAS  PubMed  Google Scholar 

  60. Waldor, M.K., Rubin, E.J., Gregory, D.N., et al., Mol. Microbiol., 1997, vol. 24, pp. 917–926.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Microbe Russian Anti-Plague Research Institute, Saratov, Russia

    N. I. Smirnova, A. A. Goryaev & V. V. Kutyrev

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  1. N. I. Smirnova
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  2. A. A. Goryaev
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  3. V. V. Kutyrev
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Correspondence to N. I. Smirnova.

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Original Russian Text © N.I. Smirnova, A.A. Goryaev, V.V. Kutyrev, 2010, published in Molekulyarnaya Genetika, Mikrobiologiya i Virusologiya, 2010, No. 4, pp. 11–19.

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Smirnova, N.I., Goryaev, A.A. & Kutyrev, V.V. The evolution of the Vibrio cholerae genome during the modern period. Mol. Genet. Microbiol. Virol. 25, 148–157 (2010). https://doi.org/10.3103/S0891416810040026

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