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Heterogeneity of the p83/100 gene of Borrelia from the Borrelia burgdorferi sensu lato complex

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Abstract

Thirty-five full-length nucleotide sequences of the a83/100 gene of the Borrelia burgdorferi sensu lato complex are determined. A high level of homology is observed in the nucleotide sequences corresponding to the strains and isolates of Borrelia afzelii. The analysis of the nucleotide sequences reveals two groups of Borrelia garinii. The most variable p83/100 gene region harboring species-typical insertions and deletions is shown to be a part of the region where the antigenic determinants of protein are encoded. According to the data obtained in this work, the modification of the P83/100 protein structure and immunological properties may be suggested to exist even within a species. The results of this work can be used for obtaining recombinant P83/100 proteins useful for diagnostic applications.

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Authors and Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, pr. Akademika Lavrent’eva 8, Novosibirsk-90, 630090, Russia

    N. V. Fomenko & Yu. V. Sabitova

  2. Institute for Epidemiology and Microbiology, Irkutsk Medical University, ul. Karla Marksa 3, Irkutsk, 664003, Russia

    M. A. Khasnatinov & G. A. Danchinova

  3. Scientific Production Association Virion, SPA Microgen, ul. Ivanovskogo 8, Tomsk, 634040, Russia

    N. A. Goltsova & O. V. Stronin

  4. National Center for Communicable Disease, Ulaanbaatar, Mongolia

    J. Bataa & D. Ambed

Authors
  1. N. V. Fomenko
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  2. Yu. V. Sabitova
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  3. M. A. Khasnatinov
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  4. N. A. Goltsova
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  5. G. A. Danchinova
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  6. J. Bataa
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  7. D. Ambed
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  8. O. V. Stronin
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Additional information

Original Russian Text © N.V. Fomenko, Yu.V. Sabitova, M.A. Khasnatinov, N.A. Goltsova, G.A. Danchinova, J. Bataa, D. Ambed, O.V. Stronin, 2007, published in Molekulyarnaya Genetika, Mikrobiologiya i Virusologiya, 2007, No. 4, pp. 31–36.

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Fomenko, N.V., Sabitova, Y.V., Khasnatinov, M.A. et al. Heterogeneity of the p83/100 gene of Borrelia from the Borrelia burgdorferi sensu lato complex. Mol. Genet. Microbiol. Virol. 22, 172–179 (2007). https://doi.org/10.3103/S0891416807040064

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  • DOI: https://doi.org/10.3103/S0891416807040064

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