Cytology and Genetics

, Volume 52, Issue 1, pp 40–45 | Cite as

Peculiarities of modification by astaxanthin of radiation-induced damages in the genome of human blood lymphocytes exposed in vitro on different stages of the mitotic cycle

  • D. A. KurinnyiEmail author
  • S. R. Rushkovsky
  • O. M. Demchenko
  • M. A. Pilinska


The features of astaxanthin impact (20 μg/mL) in the culture of human blood lymphocytes exposed to γ-radiation (1.0 Gy) on the G0, S, and G2 phases of the cell cycle were studied using Comet assay. Decrease in the level of DNA damages (Tail Moment index) under astaxanthin influence on lymphocytes irradiated in all stages of cell division was established, while, as a result of previous cytogenetic investigations, lack of the modifying action of astaxanthin after irradiation of cells in the G2 stage and radioprotective effect in the G0 stage of the mitotic cycle had been revealed. In G0 phase, the activation of the processes of apoptosis by astaxanthin in irradiated cells with high levels of genomic damages was found. The obtained data demonstrate that astaxanthin has a powerful radioprotective potential, mainly due to its apoptogenic properties.


culture of human peripheral blood lymphocytes gamma-irradiation astaxanthin Comet assay DNA injuries apoptosis 


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Copyright information

© Allerton Press, Inc. 2018

Authors and Affiliations

  • D. A. Kurinnyi
    • 1
    Email author
  • S. R. Rushkovsky
    • 2
  • O. M. Demchenko
    • 1
  • M. A. Pilinska
    • 1
  1. 1.State Institution “National Research Center for Radiation Medicine,”National Academy of Medical Sciences of UkraineKyivUkraine
  2. 2.Educational and Research Center “Institute of Biology and Medicine,”Taras Shevchenko National University of KyivKyivUkraine

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