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The Inclusion of Timolol and Lisinopril in Calcium Phosphate Particles Covered by Chitosan: Application in Ophthalmology

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Moscow University Chemistry Bulletin Aims and scope

Abstract

Chitosan-covered calcium phosphate nanoparticles with the mean dynamic radii of 30 to 130 nm and ζ-potential of +22 ± 4 mV containing timolol and lisinopril are prepared and characterized. These particles are formed by the amorphous phase represented by amorphous calcium phosphate Ca x (PO4) y · zH2O and the crystalline phase represented by hydrated calcium hydrophoshate (brushite) CaHPO4 · 2H2O. The experiments in vivo demonstrated that the inclusion of timolol into calcium phosphate particles covered with chitosan substantially prolonged its effect on the intraocular pressure.

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Abbreviations

CaPh-particles:

calcium phosphate nanoparticles

IOP:

intraocular pressure

TPP:

tripolyphosphate

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Author information

Authors and Affiliations

  1. Department of Chemistry, Moscow State University, Moscow, 119991, Russia

    I. I. Nikolskaya, A. I. Eltsov, I. V. Gachok & O. A. Kost

  2. Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health, Moscow, 105062, Russia

    O. V. Beznos & N. B. Chesnokova

  3. Federal Research Center “Fundamentals of Biotechnology,”, Russian Academy of Sciences, Moscow, 119071, Russia

    V. P. Varlamov

Authors
  1. I. I. Nikolskaya
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  2. O. V. Beznos
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  3. A. I. Eltsov
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  4. I. V. Gachok
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  5. N. B. Chesnokova
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  6. V. P. Varlamov
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  7. O. A. Kost
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Corresponding author

Correspondence to O. A. Kost.

Additional information

Original Russian Text © I.I. Nikolskaya, O.V. Beznos, A.I. Eltsov, I.V. Gachok, N.B. Chesnokova, V.P. Varlamov, O.A. Kost, 2018, published in Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya, 2018, No. 2, pp. 170–176.

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Nikolskaya, I.I., Beznos, O.V., Eltsov, A.I. et al. The Inclusion of Timolol and Lisinopril in Calcium Phosphate Particles Covered by Chitosan: Application in Ophthalmology. Moscow Univ. Chem. Bull. 73, 85–89 (2018). https://doi.org/10.3103/S0027131418020116

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  • DOI: https://doi.org/10.3103/S0027131418020116

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