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Comparative Study on the Combined Effects of Bunazosin and Nipradilol or Timolol on Intraocular Pressure in Normotensive Rabbits

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Abstract

Purpose

To compare the ocular hypotensive effect of nipradilol and timolol in combination with bunazosin in rabbits.

Methods

The intraocular pressure (IOP) in normal rabbits was measured using an applanation pneumatonograph. Nipradilol, timolol, and bunazosin were instilled, individually or in combination, into the inferior conjunctival sac.

Results

Nipradilol (0.25%), timolol (0.5%), and bunazosin (0.01%) individually lowered IOP. The IOP-lowering effects of both nipradilol and timolol were significantly enhanced by the combined application of bunazosin (0.01%). In the presence of 5% timolol or 0.1% bunazosin, IOP was further lowered by the addition of nipradilol. The IOP-lowering effect of nipradilol was partly inhibited by pretreatment with c-PTIO (10 mM), a nitric oxide (NO)-trapping agent.

Conclusions

The present study demonstrated that the IOP-lowering effects of nipradilol are due to β- and α1-blocking and NO-donating actions, and bunazosin has an additive effect on the IOP-lowering effect of nipradilol or timolol. Jpn J Ophthalmol 2005;49:523–526 © Japanese Ophthalmological Society 2005

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan

    Masahiro Orihashi, Hiroshi Tsuneki & Ikuko Kimura

  2. Teika Pharmaceutical Company, Toyama, Japan

    Yuichiro Shima

Authors
  1. Masahiro Orihashi
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  2. Yuichiro Shima
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  3. Hiroshi Tsuneki
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  4. Ikuko Kimura
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Corresponding author

Correspondence to Hiroshi Tsuneki.

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Orihashi, M., Shima, Y., Tsuneki, H. et al. Comparative Study on the Combined Effects of Bunazosin and Nipradilol or Timolol on Intraocular Pressure in Normotensive Rabbits. Jpn J Ophthalmol 49, 523–526 (2005). https://doi.org/10.1007/s10384-004-0232-2

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  • DOI: https://doi.org/10.1007/s10384-004-0232-2

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