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Synthesis and study of NOS-inhibiting activity of 2-N-acylamino-5,6-dihydro-4H-1,3-thiazine

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Moscow University Chemistry Bulletin Aims and scope

Abstract

The synthesis and results of in vitro and in vivo testing of 2-N-acetylamino-, 2-N-benzoylamino-,2-N-cyclohexanecarbonylamino-, and 2-N-(1-adamantanecarbonyl)amino-5,6-dihydro-4H-1,3-thiazines for NOS-inhibiting activity have been described.

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Authors and Affiliations

  1. Department of Radiochemistry, Department of Physical Chemistry, Moscow, Russia

    T. P. Trofimova, O. N. Zefirova, A. A. Mandrugin, V. M. Fedoseev, D. I. Peregud, M. V. Onufriev, N. V. Gulyaeva & S. Ya. Proskuryakov

  2. National Research Center of Narcology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia

    D. I. Peregud

  3. Institute for Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    M. V. Onufriev & N. V. Gulyaeva

  4. Medical Radiology Research Center, Russian Academy of Medical Sciences, Moscow, Russia

    S. Ya. Proskuryakov

Authors
  1. T. P. Trofimova
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  2. O. N. Zefirova
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  3. A. A. Mandrugin
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  4. V. M. Fedoseev
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  5. D. I. Peregud
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  6. M. V. Onufriev
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  7. N. V. Gulyaeva
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  8. S. Ya. Proskuryakov
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Corresponding author

Correspondence to T. P. Trofimova.

Additional information

Original Russian Text © T.P. Trofimova, O.N. Zefirova, A.A. Mandrugin, V.M. Fedoseev, D.I. Peregud, M.V. Onufriev, N.V. Gulyaeva, S.Ya. Proskuryakov, 2008, published in Vestnik Moskovskogo Universiteta. Khimiya, 2008, No. 5, pp. 328–331.

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Trofimova, T.P., Zefirova, O.N., Mandrugin, A.A. et al. Synthesis and study of NOS-inhibiting activity of 2-N-acylamino-5,6-dihydro-4H-1,3-thiazine. Moscow Univ. Chem. Bull. 63, 274–277 (2008). https://doi.org/10.3103/S0027131408050088

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  • DOI: https://doi.org/10.3103/S0027131408050088

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