Skip to main content
Log in

Infections of external ventricular drainages

  • Research Article
  • Published:
Central European Journal of Medicine

Abstract

Aim

The most common complication of the external ventricular drainage (EVD) is an infection, which is linked to different risk factors. We tried to investigate possible links between different risk factors and incidences of an infection of the EVD.

Materials and Methods

We used a retrospective method and examined records of 176 patients. These patients were admitted to the University clinical centre Maribor between January 2004–December 2005 and January 2009–December 2010 and had an EVD inserted.

Results

Our research had shown a high overall occurrence of infection, namely 23.3 %. We found a significantly higher incidence of infection in patients with a subarachnoid haemorrhage as an etiology. The likelihood of an infection increased with each catheter replacement and with EVDs inserted for more than 7 days. The incidence of infection in the group of patients with an impregnated catheter was significantly lower. The protective role of impregnated catheters is larger in terms of local effect and smaller in broader effect in CSF space.

Conclusions

An easy retrograde route for microorganisms to enter ventricular space should be prevented with appropriate wound care and by replacing EVDs only in cases of mechanical dysfunction or extraction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Ratilal O.B., Costa J., Sampaio C., Antibiotic prophylaxis for surgical introduction of intracranial ventricular shunts, The Cochrane Collaboration. Published by John Wiley & Sons, 2009: Ratilal B.O., Costa J., Sampaio C., Antibiotic prophylaxis for surgical introduction of intracranial ventricular shunts. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. No.: CD005365: p. 2–3

  2. Lyke K.E., Obasanjo O.O., Williams M.A., et al., Ventriculitis complicationg use of intraventricular catheters in adult neurosurgical patients. Clin. Infect. Dis., 2001, 33(12), 2028–2033

    Article  PubMed  CAS  Google Scholar 

  3. Popp W., Muller O., Schoch B., et al. Infektionsraten bei externen Ventrikeldrainagen. Hyg. Med. 2004, 29(Suppl 1)

  4. Claus B.C., Shunt Infection. In: H. Richard Winn (Eds.), Youmans Neurological Surgery, 5th Ed., Vol. 3, Philadelphia: Saunders, 2004, 3419–3425

    Google Scholar 

  5. Lozier A.P., Sciacca R.R., Romagnoli M.F., et al., Ventriculostomy-related infections: a critical review of the literature, Neurosurgery, 2002, 51(1), 170–181; discussion: 181–182

    Article  PubMed  Google Scholar 

  6. Ragel B.T., M.D., Browd S.R., M.D., Ph. D., and Schmidt R.H., M.D., Ph.D. Surgical shunt infection: significant reduction when using intraventricular and systemic antibiotic agents, J. Neurosurg., 2006, 105, 242–247

    Article  PubMed  Google Scholar 

  7. Cheng H L.O., MBBS, Spelman D., FRACP, FRCPA, Bailey M., PhD, Cooper J., MD, FRACP, FJFICM, Rosenfeld J.V., MS, FRACS, and Brecknell J.E., PhD, FRCS. External ventricular drain infections are independent of drain duration: an argument against elective revision, J. Neurosurg., 2007, 106, 378–383

    Article  Google Scholar 

  8. Prabhu V.C., Kaufman H.H., Voelker J.L., Aronoff S.C., Niewiadomska-Bugaj M., Mascaro S., et al. Prophylactic antibiotics with intracranial pressure monitors and external ventricular drains: a review of the evidence, Surg. Neurol.,1999, 52, 226–236, discussion 236–237

    Article  PubMed  CAS  Google Scholar 

  9. Megerian J.T., Comparative Infection Rates for the Codman BACTISEAL TM External Ventricular Drainage (EVD) System, Clinical Research Review. Codman & Shurtleff

  10. Alleyne C.H. Jr., Hassan M., Zabramski J.M., The efficacy and cost of prophylactic and perioprocedural antibiotics in patients with external ventricular drains, Neurosurgery, 2000, 47, 1124–1127, discussion 1127–1129

    Article  PubMed  Google Scholar 

  11. Guyot L.L., Dowling C., Diaz F.G., Michael D.B., Cerebral monitoring devices: analyzes of complications, Acta Neurochir., 1998, Supp. 71, 47–49

    CAS  Google Scholar 

  12. Choksey M.S., Malik I.A., Zero tolerance to shunt infections: can it be achieved? J. Neurol. Neurosurg. Psychiatry, 2004, 75, 87–91

    PubMed  CAS  Google Scholar 

  13. Borgbjerg B.M., Gjerris F., Albeck M.J., et al., Risk of infection after cerebrospinal fluid shunt: an analysis of 884 first-time shunts. Acta Neurochir., 1995, 136, 1–7

    Article  CAS  Google Scholar 

  14. Davis S.E., Levy M.L., McComb J.G., et al., Does age or other factors influence the incidence of ventriculoperitoneal shunt infections? Pediatr. Neurosurg., 1999, 30, 253–257

    Article  PubMed  CAS  Google Scholar 

  15. Stenager E., Gerner-Smidt P., Kock-Jensen C., Ventriculostomy related infections — an epidemiological study. Acta Neurochir. (Wien), 1986, 83, 20–23

    Article  CAS  Google Scholar 

  16. Korinek A.M., Reina M., Boch A.L., et al., Prevention of external ventricular drain-related ventriculitis, Acta Neurochir. (Wien), 2005, 147, 39–46

    Article  Google Scholar 

  17. Pfisterer W., Muehlbauer M., Czech T., et al., Early diagnosis of external ventricular drainage infection: results of a prospective study, J.Neurol. Neurosurg. Psychiatry, 2003, 74, 929–932

    Article  PubMed  CAS  Google Scholar 

  18. Ehtisham A., Taylor S., Bayless L., et al., Placement of external ventricular drains and intracranial pressure monitors by neurointensivists, Neurocrit.Care, 2009, 10, 241–247

    Article  PubMed  Google Scholar 

  19. Scheithauer S, Buergel U, Ryang YM, Haase G, Schiefer J, Koch S, et al. Prospective surveillance of drain-associated meningitis/ventriculitis in a neurosurgery and a neurologic intensive care unit. J Neurol Neurosurg Psychiatry 2009; 80: 1381–1385

    Article  PubMed  CAS  Google Scholar 

  20. Mayhall C.G., Archer N.H., Lamb V.A., Spadora A.C., Baggett J.W., Ward J.D., et al, Ventriculostomy-related infections: A prospective epidemiologic study, N. Engl. J. Med., 1984, 310, 553–559

    Article  PubMed  CAS  Google Scholar 

  21. Williams T.A., PhD, Gavin L.D., PhD, Geoeffrey J.D., MBBS, FCICM., Bright R., RN, Van Heerden V. P., PhD, Decrease in proven ventriculitis by reducing the frequency of cerebrospinal fluid sampling from extraventricular drains, J.Neurosurg., 2011

  22. Khanna R.K., Rosenblum M.L., Rock J.P., Malik G.M., Prolonged external ventricular drainage with percutaneous long-tunnel ventriculostomies, J. Neurosurg., 1995, 83, 791–794

    Article  PubMed  CAS  Google Scholar 

  23. Luerssen T.G., Chesnut R.M., Van Berkum-Clark M., Marshall L.F., Klauber M.R., Blunt B.A., et al., Post-traumatic cerebrospinal fluid infections in the Traumatic Coma Data Bank: the influence of the type and management of ICP monitors, in Avezaat C.J.J., Van Eijndhoven J.H.M., Mass A.I.R., Tans J.T.J. (Eds): Intracranial Pressure VIII: Proceedings of the 8th International Symposium on Intracranial Pressure, Berlin, Springer-Verlag, 1993, pp 42–4519

    Chapter  Google Scholar 

  24. Wong G.C.K., Poon W.S., Wai S., Yu L.M., Lyon D., Lam J.M.K., Failure of regular external drain exchange to reduce cerebrospinal fluid infection: result of a randomised controlled trial, J. Neurosurg. Psychiatry, 2002, 73, 759–761

    Article  CAS  Google Scholar 

  25. Piatt J.H. Jr., Carlson C.V., A search for determinants of cerebrospinal fluid shunt survival: retrospective analysis of a 14-year institutional experience, Pediatr. Neurosurg., 1993, 19, 233–242

    Article  PubMed  Google Scholar 

  26. Zabramski M.J., M.D., Whiting D., M.D., Darouiche R.O., M.D., Horner T.G., M.D., Olson J., M.D., Robertson C., M.D., and Hamilton A.J., M.D., Efficacy of antimicrobial-impregnated external ventricular drain catheters: a prospective, randomized, controlled trial, J. Neurosurg., 2003, 98, 725–730

    Article  PubMed  Google Scholar 

  27. Soleman J, Marbacher S., Fandino J., Fathi A.R., Is the use of antibiotic-impregnated external ventricular drainage beneficial in the management of iatrogenic ventriculitis?, Acta Neurochir. (Wien), 2012, 154(1), 161–4, discussion 164

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jasmina Golc.

About this article

Cite this article

Strojnik, T., Golc, J. & Zakelšek, J. Infections of external ventricular drainages. cent.eur.j.med 8, 250–256 (2013). https://doi.org/10.2478/s11536-012-0115-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2478/s11536-012-0115-8

Keywords

Navigation