Abstract
Changes in circadian rhythms of dROMs, Oxy-ads and SHp during reproductive stages were studied in Comisana ewes. Twelve ewes were divided in two equal groups. The experimental group consisted of ewes undergoing gestation and lactation following artificial insemination and the control group consisted of non-pregnant ewes. Blood samples were collected every 3 h over a 24 h period, 20 days before insemination, on days 100 and 140 of pregnancy, on days 10, 30 and 200 post-partum and during the dry period. In the control group, blood samples were collected on the same days and with the same procedures as those used for the experimental group. A significant effect of time on all parameters studied was observed in the experimental group. Daily rhythms of the parameters studied were observed in the control group in all experimental conditions, and in the experimental group during pre-pregnancy and dry periods. We conclude that the reproductive status of sheep affects oxidative stress markers in blood and their circadian rhythms.
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Weinert D., Waterhouse J., The circadian rhythm of core temperature: Effects of physical activity and aging, Physiol. Behav., 2007, 90, 246–256
Czesnikiewicz-Guzik M., Konturek S.J., Loster B., Wisniewska G., Majewski, S., Melatonin and its role in oxidative stress related diseases of oral cavity, J. Physiol. Pharmacol., 2007, 58, 5–19
Mccord J.M., The evolution of free radicals and oxidative stress, Am. J. Med., 2000, 108, 652–657
Freidovich I., Fundamental aspects of reactive oxygen species, or what’s the matter with oxygen?, Ann. NY Acad. Sci., 1999, 893, 13–20
Matsuo M., Kaneko T, The chemistry of reactive oxygen species and related free radicals, In: Radak Z., (Ed), Free radicals in exercise and aging, Human kinetics, Leeds: Pudsey, United Kindom, 2000
Saleh M.A., Al-Salahy M.B., Sanousi S.A., Corpuscular oxidative stress in desert sheep naturally deficient in copper, Small Rum. Res., 2008, 80, 33–38
Foyer C.H., The redox state and circadian rhythms, Ann. Bot., 2002, 89, 500–501
Berger J., A two-clock model of circadian timing in the immune system of mammals, Pathol. Biol., 2008, 56, 286–291
Krishnan N., Davis A.J., Giebultowicz J.M., Circadian regulation of response to oxidative stress in Drosophila melangaster, Biochem. Biophys. Res. Commun., 2008, 374, 299–303
Simonetta S.H., Romanowski A., Minniti A.N., In Estrosa N.C., Golombek D.A., Circadian stress tolerance in adult Caenorhabditis elegans, J. Comp. Physiol. A, Neuroethol. Sens. Neural. Behav. Physiol., 2008, 194, 821–828
Harper M.E., Bevilacqua L., Hagopian K., Weindruch R., Ramsey J.J., Ageing, oxidative stress, and mitochondrial uncoupling, Acta Physiol. Scand., 2004, 182, 321–331
Zheng X., Yang Z., Yue Z., Avarez J.D., Sehgal A., FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress, Proc. Natl. Acad. Sci. USA, 2007, 104, 15899–15904
Mongrain V., Cermakian N., Clock genes in health and diseases, J. Appl. Biomed., 2009, 7, 15–33
Piccione G., Borruso M., Fazio F., Grasso F., Caola G., Oxidative stress evaluation during milking period in the ewes, J. Appl. Anim. Res., 2006, 29, 109–112
Piccione G., Borruso M., Giannetto C., Morgante M., Giudice E., Assessment of oxidative stress in dry and lactating cows, Acta Agric. Scand. A, 2007, 57, 101–104
Piccione G., Giannetto C., Fazio F., Pennisi P., Caola G., Evaluation of total locomotor activite and oxidative markers daily rhythms in sheep, Biol. Rhythm Res., 2010, DOI: 10.1080/09291010903408225
Nelson K., Tong J.L., Lee J.K., Halberg F., Methods for cosinor rhythmometry, Chronobiologia, 1979, 6, 305–323
Refinetti R., Non-stationary time series and the robustness of circadian rhythms, J. Theor. Biol., 2004, 227, 571–581
Spätling L., Fallenstein F., Huch A., Huch R., Rooth G., The variability of cardiopulmonary adaptation to pregnancy at rest and during exercise, Br. J. Obstet. Gynaecol., 1992, 99, 1–40
Halliwell B., Gutteridge J.M., The antioxidants of human extracellular fluids, Arch. Biochem. Biophys., 1990, 280, 1–8
Stefanon B., Colitti M., Gabai G., Knight C.H., Wilde C.J., Mammary apoptosis and lactation persistency in dairy animals, J. Dairy Res., 2002, 69, 37–52
Löhrke K., Viergutz T., Kanitz W., Göllnitz K., Hurtienne A., Schweigert F.J., High milk yield in dairy cows associated with oxidant stress, J. Vet. Res., 2004, 8, 70–78
Gorbacheva V.J., Kondratov R., Zhang S., Cherukuri S., Gudkov A.V., Takahashi J.S., et al., Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex, Proc. Natl. Acad. Sci. USA, 2005, 102, 3407–3412
Gachon F., Olela F.F., Schaad O., Descombes P., Schibler U., The circadian PAR-domain basis leucin zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification, Cell Metab., 2006, 4, 25–36
Lee J.E., Edery I., Circadian regulation in the ability of Drosophila to combat phatogenic infections, Curr. Biol., 2008, 18, 195–199
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Piccione, G., Giannetto, C., Fazio, F. et al. Influence of reproductive status on the daily rhythms of oxidative stress markers in Ovis aries . cent.eur.j.biol. 5, 384–390 (2010). https://doi.org/10.2478/s11535-010-0012-6
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DOI: https://doi.org/10.2478/s11535-010-0012-6