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Binuclear copper complexes with non-steroidal anti-inflammatory drugs as studied by electrospray ionization mass spectrometry

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Central European Journal of Chemistry

Abstract

The solutions containing one of the copper salts (CuCl2, Cu(ClO4)2, Cu(NO3)2, and CuSO4) and one of the non-steroidal anti-inflammatory drugs (NSAIDs, ibuprofen, ketoprofen or naproxen) were analyzed by electrospray ionization mass spectrometry. Three of the salts, namely CuCl2, Cu(ClO4)2 and Cu(NO3)2, yielded binuclear complexes of drug:metal stoichiometry 1:2. Existence of the complexes of such stoichiometry has not been earlier observed. For copper(II) chloride the complexes (ions of the type [M-HCOOH+Cu2Cl]+ and [M+Cu2Cl]+, M stands for the drug molecule) were formed in the gas phase. When copper(II) perchlorate or copper(II) nitrate was used, the observed binuclear copper complexes (ions of the type [M-H+Cu2(ClO4)2+CH3OH]+, [M-H+Cu2(ClO4)2]+ and [M-H+Cu2(NO3)2+CH3OH]+, [M-H+Cu2(NO3)2]+) were observed at low cone voltage, thus these complexes must have already existed in the solution analysed. Therefore, such complexes may also exist under physiological conditions.

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Authors and Affiliations

  1. Faculty of Chemistry, Adam Mickiewicz University, 60-780, Poznań, Poland

    Kaja Kowcun & Rafał Frański

  2. Institute of Chemistry, Poznań University of Technology, 60-965, Poznań, Poland

    Magdalena Frańska

Authors
  1. Kaja Kowcun
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  2. Magdalena Frańska
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  3. Rafał Frański
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Correspondence to Rafał Frański.

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Kowcun, K., Frańska, M. & Frański, R. Binuclear copper complexes with non-steroidal anti-inflammatory drugs as studied by electrospray ionization mass spectrometry. cent.eur.j.chem. 10, 320–326 (2012). https://doi.org/10.2478/s11532-011-0139-y

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  • DOI: https://doi.org/10.2478/s11532-011-0139-y

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